Low Incidence of Ulcerative Colitis and Proctitis in Bangladeshi Migrants in Britain

Venkataraman, Jayanthi; Probert, Chris; Pollock, D. J.; Baithun, Suhail; Rampton, David; Mayberry, J F

doi:10.1159/000200936

Cited by 29 publications

(22 citation statements)

References 7 publications

(13 reference statements)

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“…57 Studies from East London reported a low incidence of IBD in Bangladeshi migrants in the 1980s. 37,38 A more recent study has shown an increase in CD incidence in Bangladeshi migrants from 2.3 (1981-1989) to 7.3 (1997-2001), and an increase in UC incidence from 2.4 (1981-1989) to 8.2 (1997-2001). 39 In this study, most UC patients (13 of 16) were born in Bangladesh as compared to 8/19 CD cases.…”

Section: Epidemiologymentioning

confidence: 99%

“…A number of studies related to IBD in South Asian immigrants to the United Kingdom (UK) were published in the 1990s. [5][6][7][36][37][38] Incidence and prevalence data from Leicestershire reported a higher incidence of UC, but an equal or lower incidence of CD, in individuals of South Asian compared to European ethnicity. [5][6][7] Hindus and Sikhs had a particularly higher incidence of UC than other ethnic groups in Leicester, 5 while Hindus had a lower incidence of CD than Europeans.…”

Section: Epidemiologymentioning

confidence: 99%

“…Asian immigrants to the West. A number of studies related to IBD in South Asian immigrants to the United Kingdom (UK) were published in the 1990s 5–7,36–38 . Incidence and prevalence data from Leicestershire reported a higher incidence of UC, but an equal or lower incidence of CD, in individuals of South Asian compared to European ethnicity 5–7 .…”

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confidence: 99%

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Inflammatory bowel disease in Asia: A systematic review

Prideaux

Kamm

Cruz

et al. 2012

J of Gastro and Hepatol

302

249

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The incidence and prevalence of inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), are lower in Asia than in the West. However, across Asia the incidence and prevalence of IBD has increased rapidly over the last two to four decades. These changes may relate to increased contact with the West, westernization of diet, increasing antibiotics use, improved hygiene, vaccinations, or changes in the gut microbiota. Genetic factors also differ between Asians and the Caucasians. In Asia, UC is more prevalent than CD, although CD incidence is rapidly increasing in certain areas. There is a male predominance of CD in Asia, but a trend towards equal sex distribution for UC. IBD is diagnosed at a slightly older age than in the West, and there is rarely a second incidence peak as in the West. A positive family history is much less common than in the West, as are extra-intestinal disease manifestations. There are clear ethnic differences in incidence within countries in Asia, and an increased incidence in IBD in migrants from Asia to the West. Research in Asia, an area of rapidly changing IBD epidemiology, may lead to the discovery of critical etiologic factors that lead to the development of IBD.

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Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

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Inflammatory bowel disease in Asia: A systematic review

Prideaux

Kamm

Cruz

et al. 2012

J of Gastro and Hepatol

302

249

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“…The incidence rates of UC and CD, expressed in 100 000 person-years and the prevalence rates expressed per 100 000 population in Asians and Western patients (selected population groups) are as shown for comparison in Tables 1 and 2. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] In the absence of an IBD registry, population statistics have been difficult to obtain. Many studies are hospitalbased studies of endoscopically and histologically confirmed cases of IBD extrapolated to the area that is served by the hospital, using the population of the area concerned as the denominator.…”

Section: Incidence and Prevalence Datamentioning

confidence: 99%

Inflammatory bowel disease: A survey of the epidemiology in Asia

Goh¹,

Xiao²

2009

J of Digest Diseases

113

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Inflammatory bowel disease (IBD) has long been considered a disease that affects predominantly a Western population. The incidence and prevalence rates from Asian populations are much lower in comparison. More recent data, however, have shown significantly higher rates in Asians and time trend studies have shown an increase in the incidence of ulcerative colitis (UC) and a similar but lower rise in Crohn's disease (CD). The epidemiological changes that are taking place mirror that of the Western experience seen 50 years previously and seem to occur in parallel with the rapid socioeconomic development taking place in Asia. It appears that certain racial groups are more prone than others to develop IBD. For instance, Indians in South‐East Asia have higher rates compared to Chinese and Malays. While there is host genetic predisposition, environmental factor(s) may be responsible for this difference. Migrant studies of South Asians in the UK, where second‐generation immigrants have assumed incidence rates as high as the indigenous whites and Asian Jews who develop high incidence rates comparable to Jews from Europe or North America in Israel point to the role of environmental factors. It is unclear which specific factors are responsible. Studies have suggested a change in diet to a more Westernized one may underlie this epidemiological change in the Asian population. It is likely that there are racial groups amongst Asians who are more susceptible to IBD and who will demonstrate a higher frequency of IBD when exposed to putative environmental factors.

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“…In the earlier study, during the 1980s, the standardised incidences of UC (10 5 cases/year) in South Asians also differed within ethnic groups: 16.5, 10.8 and 6.2 in Sikhs, Hindus and Muslims respectively [9]. A later study reported on the incidence of UC in the Bangladeshi community in East London which was amongst the lowest in the world, with mean standardised incidence (10 5 cases/year) of 1.8 compared with 10.8 in the South Asian group in Leicester over the same time period [11]. …”

Section: Introductionmentioning

confidence: 99%

Colectomy Rates for Ulcerative Colitis Differ between Ethnic Groups: Results from a 15-Year Nationwide Cohort Study

Misra

Askari

Faiz

et al. 2016

Canadian Journal of Gastroenterology and Hepatology

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Introduction. Previous epidemiological studies suggest a higher rate of pancolonic disease in South Asians (SA) compared with White Europeans (WE). The aim of the study was to compare colectomy rates for ulcerative colitis (UC) in SA to those of WE. Methods. Patients with UC were identified from a national administrative dataset (Hospital Episode Statistics, HES) between 1997 and 2012 according to ICD-10 diagnosis code K51 for UC. The colectomy rate for each ethnic group was calculated as the proportion of patients who underwent colectomy from the total UC cases for that group. Results. Of 212,430 UC cases, 73,318 (35.3%) were coded for ethnicity. There was no significant difference in the colectomy rate between SA and WE (6.93% versus 6.90%). Indians had a significantly higher colectomy rate than WE (9.8% versus 6.9%, p < 0.001). Indian patients were 21% more likely to require colectomy for UC compared with WE group (OR: 1.21, 95% CI: 1.04–1.42, and p = 0.001). Conclusions. Given the limitations in coding, the colectomy rate in this cohort was higher in Indians compared to WE. A prospectively recruited ethnic cohort study will decipher whether this reflects a more aggressive phenotype or is due to other confounding factors.

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Low Incidence of Ulcerative Colitis and Proctitis in Bangladeshi Migrants in Britain

Cited by 29 publications

References 7 publications

Inflammatory bowel disease in Asia: A systematic review

Inflammatory bowel disease in Asia: A systematic review

Inflammatory bowel disease: A survey of the epidemiology in Asia

Colectomy Rates for Ulcerative Colitis Differ between Ethnic Groups: Results from a 15-Year Nationwide Cohort Study

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