Low Incidence of Lymph Node Metastasis After Resection of Hepatitis Virus‐Related Intrahepatic Cholangiocarcinoma

Iida, Hiroya; Kaibori, Masaki; Tanaka, Shogo; Takemura, Shigekazu; Wada, Hiroshi; Hirokawa, Fumitoshi; Nakai, Toshiko; Hayashi, Michihiro; Eguchi, Hidetoshi; Kubo, Shoji

doi:10.1007/s00268-016-3843-0

Cited by 16 publications

(8 citation statements)

References 73 publications

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“…The meta-analysis also revealed that HBV infection was associated with underlying cirrhosis (odds ratio [OR], 6.44; 95% CI, 4.33 to 9.56), capsule formation (OR, 6.04; 95% CI, 3.56 to 10.26), and infrequent lymph node metastasis (OR, 0.39; 95% CI, 0.25 to 0.58). Most recently, Hiroya et al [25] indicated that the absence of viral hepatitis was associated with more frequent incidence of lymph node metastasis in ICC, which led to poor prognosis. However, their study did not separate HBV and HCV, due to limited number of patients ( n = 32).…”

Section: Discussionmentioning

confidence: 99%

Risk stratification system to predict recurrence of intrahepatic cholangiocarcinoma after hepatic resection

et al. 2017

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BackgroundPrevious nomograms for intrahepatic cholangiocarcinoma (ICC) were conducted to predict overall survival, which could be influenced by various factors. Herein, we conducted our nomogram to predict recurrence of the tumor only after hepatic resection.MethodsThe nomogram was established with prognostic factors for the relapse-free survival (RFS) analyzed from our single center cohort and was evaluated by comparing with the American Joint Committee on Cancer (AJCC) staging system for the predictive accuracy.ResultsSeropositivity of hepatitis B surface antigen (hazard ratio [HR], 0.505; 95% confidence interval [CI], 0.279 to 0.914; P = 0.024), tumor size of larger than 5 cm (HR, 1.947; 95% CI, 1.177 to 3.219; P = 0.009), Child-Pugh score of B (HR, 3.067; 95% CI, 1.293 to 7.275; P = 0.011), and lymph node metastasis (HR, 2.790; 95% CI, 1.628 to 4.781; P < 0.001) were found to be independent prognostic factors that significantly affected RFS. The calibration curve for the prediction revealed excellent agreement between estimation by our stratification system and actual RFS. The concordance C index of the nomogram (0.71; 95% CI, 0.65 to 0.77) revealed to be significantly higher than the AJCC staging system (0.66; 95% CI, 0.60 to 0.72). In the validation cohort, our risk stratification system (C-index 0.65; 95% CI, 0.59 to 0.71) also revealed more precise prediction than the AJCC staging system (C-index, 0.57; 95% CI, 0.50 to 0.64).ConclusionsOur nomogram could more accurately predict recurrence of ICC after hepatic resection than the AJCC staging system.

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Section: Discussionmentioning

confidence: 99%

Risk stratification system to predict recurrence of intrahepatic cholangiocarcinoma after hepatic resection

et al. 2017

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“…In contrast, studies in China reported that hepatitis B virus (HBV) infection is a favorable prognostic factor for ICC, 14,15 although another study in China identified HBV‐related cirrhosis as an independent risk factor for poor prognosis in patients who underwent liver resection for ICC 16 . We also showed that recurrence‐free survival (RFS) rates were significantly longer in the virus group (seropositive for hepatitis B or C) compared with the non‐virus group (no evidence of hepatitis virus infection) 17 . Others have reported that infection with hepatitis virus (HCV or HBV) had no impact on survival after liver resection for ICC 18–20 .…”

Section: Introductionmentioning

confidence: 69%

Impact of hepatitis C virus on survival in patients undergoing resection of intrahepatic cholangiocarcinoma: Report of a Japanese nationwide survey

Kaibori

Yoshii

Kashiwabara

et al. 2021

Hepatology Research

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Aim We reviewed the data of a nationwide follow‐up survey to determine the impact of hepatitis C virus (HCV) infection on the outcomes of hepatectomy for mass‐forming (MF) type, and combined mass‐forming and periductal infiltrating (MF + PI) type intrahepatic cholangiocarcinoma (ICC). Methods In total, 956 patients with ICC who underwent curative hepatic resection were included in this cohort study, and patients were classified according to virus status. Patients were classified according to virus status as follows: HCV‐related ICC (n = 138, 14.4%), hepatitis B virus (HBV)‐related ICC (n = 43, 4.5%) and non‐virus‐related ICC (n = 775, 81.1%). To control for variables, we used 1:1 propensity score‐matching to compare outcomes after surgery between HCV‐related (n = 102) and non‐virus‐related ICC cases (n = 102). Results We successfully matched HCV‐related and non‐virus‐related ICC cases with similar liver function and tumor characteristics. Patients with HCV‐related ICC had significantly shorter recurrence‐free survival (hazard ratio 0.62, 95% confidence interval 0.42–0.92, p = 0.016) and overall survival (hazard ratio: 0.57, 95% confidence interval: 0.37–0.88, p = 0.011) than patients with non‐virus‐related ICC. Cox proportional hazard analysis showed that HCV‐related ICC offered a worse prognosis than non‐virus‐related ICC. Conclusions HCV infection increases the risk of recurrence and worsens overall survival in patients after curative resection for MF and combined MF + PI type ICC.

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“…In this study, the results showed that the prognosis of patients with HBV-ICC was better than those of Con-ICC and Stone-ICC subtypes. Ding et al [24] have found that the patients with HBV-ICC can activate the immune memory produced by HBV infection previously, thereby enhancing anti-tumor immunity, and Iida et al [25] have also revealed that HBV-ICC conferred a low risk of lymph node metastasis for postoperative recurrence, which may be the reason that HBV-ICC has a relatively better prognosis than the other two etiological subtypes. Many studies [20,26,27] also found that HBV infection was a favorable prognostic factor for ICC after surgery, which was consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

Recurrence and Prognosis in Intrahepatic Cholangiocarcinoma Patients with Different Etiology After Radical Resection: A Multi-Institutional Study

Chen

et al. 2021

Preprint

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Objective We aimed to evaluate the prognosis and adjuvant chemotherapy (ACT) in intrahepatic cholangiocarcinoma (ICC) patients with different etiology after radical resection. Methods A total of 448 patients with ICC who underwent radical resection between 2010 and 2018 at ten Chinese tertiary hospitals were analyzed in the study. These patients were divided into conventional ICC (Con-ICC, n=261, 58.2%), hepatitis B virus ICC (HBV-ICC, n=102, 22.8%) and hepatolithiasis (Stone-ICC, n=85,19.0%) subtypes according to different etiology. Propensity score matching (PSM) was conducted to mitigate the baseline differences between related two subtypes. Results Univariate and multivariate analysis showed that different etiology was a prognostic factor for overall survival and relapse-free survival, and different etiology was an independent risk factor for overall survival in ICC patients, respectively (P<0.05). In addition, there was a statistical difference for overall survival in early recurrence patients among the three etiological subtypes (P<0.05). After PSM, the overall survival of patients with Stone-ICC was worse than those of Con-ICC and HBV-ICC subtypes (P<0.05), while the relapse-free survival of patients with Stone-ICC was equivalent to patients with Con-ICC and HBV-ICC (P>0.05). In Stone-ICC patients, the median overall survival was 16.0 months and 29.7 months, and the median relapse-free survival was 9.0 months and 20.0 months for non-ACT and ACT patients, respectively (P<0.05). Conclusion The prognosis of Stone-ICC patients was significantly worse than those of Con-ICC and HBV-ICC patients. Interestingly, postoperative adjuvant chemotherapy can improve the prognosis of Stone-ICC patients effectively.

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Low Incidence of Lymph Node Metastasis After Resection of Hepatitis Virus‐Related Intrahepatic Cholangiocarcinoma

Abstract: Hepatitis virus-associated mass-forming-type ICC confers a low risk of lymph node metastasis as initial postoperative recurrence.

Cited by 16 publications

References 73 publications

Risk stratification system to predict recurrence of intrahepatic cholangiocarcinoma after hepatic resection

Risk stratification system to predict recurrence of intrahepatic cholangiocarcinoma after hepatic resection

Impact of hepatitis C virus on survival in patients undergoing resection of intrahepatic cholangiocarcinoma: Report of a Japanese nationwide survey

Recurrence and Prognosis in Intrahepatic Cholangiocarcinoma Patients with Different Etiology After Radical Resection: A Multi-Institutional Study

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