Low <i>FCMR</i> mRNA expression in leukocytes of patients with Kawasaki disease six months after disease onset

Chang, Ling‐Sai; Guo, Mindy Ming‐Huey; Yan, Jia-Huei; Huang, Ying‐Hsien; Lo, Mao‐Hung; Kuo, Ho‐Chang

doi:10.1111/pai.13235

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…Total blood routine lab data were determined prior to intravenous immunoglobulin (IVIG) infusion. Echocardiography was performed in the acute stage of KD as previously described in our report [21]. Patients experiencing persistent or recurrent fever (≥38 • C) 48 h after the initiation of the first IVIG treatment were recognized as the IVIG resistance group.…”

Section: Collection Of Blood Samples For Blood Mercury Estimationsmentioning

confidence: 99%

Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome

Chang

Yan

et al. 2020

IJERPH

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The risk of ethnic Kawasaki disease (KD) has been proposed to be associated with blood mercury levels in American children. We investigated the blood levels of mercury in children with KD and their association with disease outcome. The mercury levels demonstrated a significantly negative correlation with sodium levels (p = 0.007). However, data failed to reach a significant difference after excluding the child with blood mercury exceeding the toxic value. The findings indicate that KD patients with lower sodium concentrations had a remarkably higher proportion of intravenous immunoglobulin (IVIG) resistance (p = 0.022). Our patients who had lower mercury levels (<0.5 μg/L) had more changes in bacille Calmette-Guerin. Mercury levels in 14/14 patients with coronary artery lesions and 4/4 patients with IVIG resistance were all measured to have values greater than 1 μg/L (while average values showed 0.92 μg/L in Asian American children). Mercury levels had no correlations with IVIG resistance or coronary artery lesion (CAL) formation (p > 0.05). CAL development was more common in the incomplete group than in the complete KD group (p = 0.019). In this first report about mercury levels in KD patients, we observed that the juvenile Taiwanese had higher mercury concentration in blood compared to other populations.

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Section: Collection Of Blood Samples For Blood Mercury Estimationsmentioning

confidence: 99%

Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome

Chang

Yan

et al. 2020

IJERPH

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“…Lipid profile abnormalities in KD were found to persist for 1 year in a cohort study with 27 children (10). In addition to cardiovascular sequelae, KD has been demonstrated to have other long-term effects resulting in common health problems, such as allergy diseases and impaired immunity (11,12). In this review article, the current understanding of the link between allergies and KD are discussed (Figure 1).…”

Section: Introductionmentioning

confidence: 96%

Kawasaki Disease and Allergic Diseases

Huang

Guo

et al. 2021

Front. Pediatr.

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Background: Kawasaki disease (KD) is an inflammatory disorder with an unknown etiology. It is the leading cause of acquired heart disease, which leads to coronary vasculitis among children. Studies of frequent manifestation of allergic diseases in children with KD have been the subject of mounting clinical interest. However, evidence supporting the association between KD and allergies has yet to be systematically reviewed.Methods: In this article, we reviewed current literature regarding the association between KD and allergic diseases. References for this review were identified through searches of PubMed, Cochrane, and Embase through the end of August 2020.Results: The results of the analyses of immune repertoire, clinical, and epidemiological studies have indicated some of the characteristics of infectious disease for KD. Although some allergic disorders, such as asthma, may be exacerbated by viral infections, allergies are typically caused by an allergen that triggers an immune response, with the potential involvement of type 2 inflammation and immune disturbances leading to tissue remodeling in genetically susceptible hosts. The effect of intravenous immunoglobulin is multi-faceted and results in a decrease in activating Fc gamma receptor IIA and an increase in anti-inflammatory eosinophils. The findings from this review demonstrate that children who have suffered from KD are more likely to have allergic rhinitis than the general population and their siblings, a condition that lasts until the age of 17. When followed up as teenagers and adults, children with KD are more likely to develop urticaria.Conclusions: This review supports that allergic diseases, such as allergic rhinitis, have been demonstrated to increase following KD. Therefore, the importance of allergic diseases in patients with KD should be emphasized in long-term care. Interventions that include strategies for managing allergies in children with KD would be beneficial.

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“…days after IVIG (KD2), three weeks after IVIG (KD3), six months after IVIG (KD4), and one year after IVIG (KD5) [23]. We found no significant difference in FcγR2B methylation between KD patients and controls.…”

Section: Methylation Levels Of Fcγr2b Promoter Regions On Leukocytes In Different Stages Of Kawasaki Diseasementioning

confidence: 60%

“…We studied the FcγR2B methylation of the total white blood cells in paired blood samples from 76 KD patients (see Figure 3 ). We obtained peripheral blood samples from all 76 KD subjects at five different times: within 24 h prior to IVIG treatment (KD1), 3–7 days after IVIG (KD2), three weeks after IVIG (KD3), six months after IVIG (KD4), and one year after IVIG (KD5) [ 23 ]. We found no significant difference in FcγR2B methylation between KD patients and controls.…”

Section: Resultsmentioning

confidence: 99%

Long-Term Hypermethylation of FcγR2B in Leukocytes of Patients with Kawasaki Disease

Chang

Chu

et al. 2021

JCM

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The Fc gamma receptor family contains several activating receptors and the only inhibitory receptor, FcγR2B. In this study, we investigated the dynamic methylation change of FcγR2B in different stages of Kawasaki disease (KD). We enrolled a total of 116 participants, which included patients with febrile diseases as controls and KD patients. Whole blood cells of KD patients were collected prior to intravenous immunoglobulin (IVIG) treatment (KD1), three to seven days after IVIG (KD2), three weeks after IVIG treatment (KD3), six months after IVIG (KD4), and one year after IVIG treatment (KD5). In total, 76 KD patients provided samples in every stage. Leukocytes of controls were also recruited. We performed DNA extraction and pyrosequencing. FcγR2B methylation levels were higher in KD3 compared to both the controls and KD1. A significantly higher methylation of FcγR2B was found in KD5 when compared with KD1. FcγR2B methylation levels in the IVIG-resistant group were lower than those in the IVIG-responsive group at KD1-3 (p = 0.004, 0.004, 0.005 respectively). This study is the first to report the dynamic change of FcγR2B methylation and to demonstrate long-term hypermethylation one year after disease onset. Hypomethylation of FcγR2B is associated with IVIG resistance.

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Low FCMR mRNA expression in leukocytes of patients with Kawasaki disease six months after disease onset

Cited by 8 publications

References 26 publications

Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome

Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome

Kawasaki Disease and Allergic Diseases

Long-Term Hypermethylation of FcγR2B in Leukocytes of Patients with Kawasaki Disease

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