Low HOXC10 expression in liver cancer regulates proliferation via a mechanism involving miR‑221 and the MAPK signaling pathway

Ma, Kexin; Zhao, Cheng; Guo, Kun; Fu, Zhaoyu; Chi, Che; Dong, Bing; Peng, Chong; Shaoming, Zhang; Liu, Wuguang; Yang, Zhifu; Liang, Rui; Wang, Liming

doi:10.3892/ol.2020.11988

Cited by 7 publications

(8 citation statements)

References 35 publications

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“…Conversely, Ma et al. ( 61 ) found that HOXC10 have negatively affected the MAPK signaling pathway, and MAPK signaling marker proteins increase significantly after HOXC10 knockdown in liver cells. This suggests that HOXC10 has diverse effects on the MAPK pathway in different tumors.…”

Section: Tumorigenesismentioning

confidence: 96%

“…We also provided a comprehensive description of HOXC10 expression regulation. Specifically, HOXC10 expression is regulated by several epigenetic processes, including DNA ( 6 , 50 , 96 ) and histone ( 5 , 97 ) methylation, posttranscriptional miRNA ( 10 – 12 , 59 , 61 , 64 , 98 ) and lncRNA ( 9 , 99 ) modifications, and ubiquitin modifications ( 100 ).…”

Section: Hoxc10 Expression Regulationmentioning

confidence: 99%

“…MicroRNAs (miRNAs) are small noncoding RNAs that can degrade or suppress the translation of target mRNAs by base pairing with the 3’-untranslated region (3’UTR) ( 106 ). Several miRNAs, such as miR-129-5p ( 10 – 12 ), miR-222-3p ( 64 ), miR-146b-5p ( 98 ), miRNA-221 ( 61 ), and miRNA-136 ( 59 ), have been reported to play a key role in regulating HOXC10 expression. These miRNAs directly target the 3’UTR of HOXC10 to inhibit HOXC10 expression.…”

Section: Hoxc10 Expression Regulationmentioning

confidence: 99%

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Role of HOXC10 in Cancer

Fang

Wang

et al. 2021

Front. Oncol.

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The HOXC10 gene, a member of the HOX genes family, plays crucial roles in mammalian physiological processes, such as limb morphological development, limb regeneration, and lumbar motor neuron differentiation. HOXC10 is also associated with angiogenesis, fat metabolism, and sex regulation. Additional evidence suggests that HOXC10 dysregulation is closely associated with various tumors. HOXC10 is an important transcription factor that can activate several oncogenic pathways by regulating various target molecules such as ERK, AKT, p65, and epithelial mesenchymal transition-related genes. HOXC10 also induces drug resistance in cancers by promoting the DNA repair pathway. In this review, we summarize HOXC10 gene structure and expression as well as the role of HOXC10 in different human cancer processes. This review will provide insight into the status of HOXC10 research and help identify novel targets for cancer therapy.

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Section: Tumorigenesismentioning

confidence: 96%

Section: Hoxc10 Expression Regulationmentioning

confidence: 99%

Section: Hoxc10 Expression Regulationmentioning

confidence: 99%

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Role of HOXC10 in Cancer

Fang

Wang

et al. 2021

Front. Oncol.

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“…Significant changes in the ratio of vitamin intake were found to affect the CpG island methylation pattern in the loci of DNMT1, DNMT3A and DNMT3B, consequently leading to increased expression of the methyltransferases [ 29 ]. Even levels of miRNAs like that of miR-133 (linked to muscle and cardiac tissue metabolism and certain kinds of cancer) [ 54 , 58 , 65 , 85 , 86 , 98 , 101 ] and miR-221 (linked to oncogenesis) [ 10 , 25 , 50 , 56 , 60 , 71 , 79 , 90 , 96 , 100 ] changed in response to a skewed ratio of intake of the two vitamins. Other than sub or supra-optimal levels of folate or B12 intake, vitamin C or ascorbic acid consumption during the perinatal period also seems significant [ 19 ].…”

Section: Maternal Dietary and Supplementary Intakesmentioning

confidence: 99%

DNA methylation and regulation of gene expression: Guardian of our health

Dhar

Saha

Mitra

et al. 2021

Nucleus

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One of the most critical epigenetic signatures present in the genome of higher eukaryotes is the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA methylation in a locus, it can serve as a repressive or activation mark for gene expression. In a crosstalk with histone modifiers, DNA methylation can consequently either inhibit binding of the transcription machinery or generate a landscape conducive for transcription. During developmental phases, the DNA methylation pattern in the genome undergoes alterations as a result of regulated balance between de novo DNA methylation and demethylation. Resultantly, differentiated cells inherit a unique DNA methylation pattern that fine tunes tissue-specific gene expression. Although apparently a stable epigenetic mark, DNA methylation is actually labile and is a complex reflection of interaction between epigenome, genome and environmental factors prior to birth and during progression of life. Recent findings indicate that levels of DNA methylation in an individual is a dynamic outcome, strongly influenced by the dietary environment during germ cell formation, embryogenesis and post birth exposures. Loss of balances in DNA methylation during developmental stages may result in imprinting disorders, while at any later stage may lead to increased predisposition to various diseases and abnormalities. This review aims to provide an outline of how our epigenome is uniquely guided by our lifetime of experiences beginning in the womb and how understanding it better holds future possibilities of improvised clinical applications.

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“…The Hox gene family consists of 39 genes divided into 4 clusters ( HOXA, HOXB, HOXC , and HOXD ) ( Cillo et al., 2001 ) located on 4 different chromosomes; the HOXC6 and HOXC10 genes are members of the HOXC cluster. The related research on HOXC6 and HOXC10 has been conducted mainly in the context of cancer ( Dang et al., 2020 ), cell proliferation and migration ( Kim et al., 2019 ; Ma et al., 2020 ), neural development ( Wu et al., 2008 ), and adipose tissue browning ( Ng et al., 2017 ). There is no research indicating that HOXC6 and HOXC10 are related to the formation of crested phenotype.…”

Section: Discussionmentioning

confidence: 99%

RNA-sequence reveals differentially expressed genes affecting the crested trait of Wumeng crested chicken

et al. 2021

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Wumeng crested chicken has a cluster of slender feathers on its head, and the underlying skull region exhibits an obvious tumor-like protrusion. This is the typical skull structure of crested chickens. The associated regulatory genes are located on autosomes and are incompletely dominant. This trait is related to brain herniation, but the genetic mechanisms of its formation and development are unclear. In this study, RNA sequencing ( RNA-Seq ) analysis was conducted on 6 skull tissue samples from 3 Wumeng crested chickens with prominent skull protrusions and 3 without a prominent skull protrusion phenotype. A total of 46,376,934 to 43,729,046 clean reads were obtained, the percentage of uniquely mapped reads compared with the reference genome was between 89.73%–91.00%, and 39,795,458–41,836,502 unique reads were obtained. Among different genomic regions, the highest frequency of sequencing reads occurred in exon regions (85.44–88.28%). Additionally, a total of 423 new transcripts and 26,999 alternative splicings ( AS ) events were discovered in this sequencing analysis. This study identified 1,089 differentially expressed genes ( DEGs ), among which 485 were upregulated and 604 were downregulated. Gene Ontology ( GO ) and Kyoto Encyclopedia of Genes and Genomes ( KEGG ) pathway analyses indicated that the DEGs were enriched in terms related to signal transduction, cell development, cell differentiation, the lysosome, serine, and threonine metabolism, and the interaction of cytokines with cytokine receptors. Based on the comprehensive analysis of DEGs combined with reported quantitative trait loci ( QTLs ), the expression of BMP2, EPHA3, EPHB1, HOXC6, SCN2B, BMP7 , and HOXC10 was verified by real-time quantitative polymerase chain reaction ( qRT-PCR ). The qRT-PCR results were consistent with the RNA-Seq results, indicating that these 7 genes may be candidates genes regulating the crested trait.

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Low HOXC10 expression in liver cancer regulates proliferation via a mechanism involving miR‑221 and the MAPK signaling pathway

Cited by 7 publications

References 35 publications

Role of HOXC10 in Cancer

Role of HOXC10 in Cancer

DNA methylation and regulation of gene expression: Guardian of our health

RNA-sequence reveals differentially expressed genes affecting the crested trait of Wumeng crested chicken

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