Low HIP1R mRNA and protein expression are associated with worse survival in diffuse large B-cell lymphoma patients treated with R-CHOP

Wong, Kah Keng; Ch’ng, Ewe Seng; Loo, Suet Kee; Husin, Azlan; Arestin, María; Møller, Michael; Pedersen, Lars Møller; Pomposo, María Puente; Gaafar, Ayman; Banham, Alison H.; Green, Tina M.; Lawrie, Charles H.

doi:10.1016/j.yexmp.2015.08.019

Cited by 14 publications

(12 citation statements)

References 39 publications

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“…Huntingtin-interacting protein 1-related (HIP1R) is an endocytic protein involved in receptor trafficking, including regulating cell surface expression of receptor tyrosine kinases. Wong et al [ 38 ] had shown that low HIP1R protein expression was associated with poorer survival in DLBCL patients treated with R-CHOP and now extend these findings. Thanks to the movement of open access of data, they were able to use data mining on three independent transcriptomic datasets of DLBCL.…”

Section: Prognostic Factors In Lymphomasupporting

confidence: 70%

New developments in the pathology of malignant lymphoma: a review of the literature published from May 2015–September 2015

Krieken

2015

J Hematopathol

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Section: Prognostic Factors In Lymphomasupporting

confidence: 70%

New developments in the pathology of malignant lymphoma: a review of the literature published from May 2015–September 2015

Krieken

2015

J Hematopathol

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“…It was calculated using receiver operating characteristics (ROC) as described in a previous study. 27 Youden index represents a biomarker’s maximum potential effectiveness when equal weight is given to both sensitivity and specificity derived from ROC curve. 28 A c 2 analysis was performed to determine any association between the serological and clinical parameters for the RA patients.…”

Section: Methodsmentioning

confidence: 99%

Anti-carbamylated protein antibodies in rheumatoid arthritis patients and their association with rheumatoid factor

Othman

Ghazali

Hamid

et al. 2017

SMJ

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Objectives:To evaluate levels of anti-carbamylated protein (anti-CarP) antibodies in rheumatoid arthritis (RA) patients and to determine their association with serological parameters and disease activity.Methods:A cross-sectional study involving 105 multiethnic RA patients (48 rheumatoid factor [RF]-positive and 57 RF-negative patients) was conducted at Hospital Universiti Sains Malaysia, Kelantan, Malaysia, from January 2015 to February 2016. Fifty healthy controls (HCs) were included. C-reactive protein (CRP), RF, anti-cyclic citrullinated peptide (anti-CCP) and anti-CarP antibodies were measured. A health assessment questionnaire (HAQ) was administered to the study participants and 28-joint Disease Activity Score (DAS28) were obtained.Results:The level of anti-CarP antibodies was significantly increased in the RA patients compared with HCs (p=0.042). The presence of anti-CarP antibodies was significantly associated with RF (p=0.019) and the HAQ (p=0.010). A significant association between the presence of anti-CarP antibodies and the DAS28 was not found (p=0.632).Conclusion:Our study provides further evidence that the level of anti-CarP antibodies is significantly elevated in RA patients.

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“…The R-CHOP-treated primary DLBCL cases (n=230) have been described previously, with 40 cases from Spain, 33 cases from Malaysia, 14 and another 157 cases from Denmark. 15 Immunostaining was performed with other markers previously.…”

Section: Patient Samplesmentioning

confidence: 99%

DNMT1 is predictive of survival and associated with Ki-67 expression in R-CHOP-treated diffuse large B-cell lymphomas

et al. 2017

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DNMT1 is a target of approved anti-cancer drugs including decitabine. However, the prognostic value of DNMT1 protein expression in R-CHOP-treated diffuse large B-cell lymphomas (DLBCLs) remains unexplored. Here we showed that DNMT1 was expressed in the majority of DLBCL cases (n = 209/230, 90.9%) with higher expression in germinal centre B-cell-like (GCB)-DLBCL subtype. Low and negative DNMT1 expression (20% cut-off, n = 33/230, 14.3%) was predictive of worse overall survival (OS; p < 0.001) and progression-free survival (PFS; p < 0.001). Nonetheless, of the 209 DNMT1 positive patients, 33% and 42% did not achieve 5-year OS and PFS, respectively, indicating that DNMT1 positive patients showed considerably heterogeneous outcomes. Moreover, DNMT1 was frequently expressed in mitotic cells and significantly correlated with Ki-67 or BCL6 expression (r = 0.60 or 0.44, respectively; p < 0.001). We demonstrate that DNMT1 is predictive of DLBCL patients' survival, and suggest that DNMT1 could be a DLBCL therapeutic target due to its significant association with Ki-67.

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Low HIP1R mRNA and protein expression are associated with worse survival in diffuse large B-cell lymphoma patients treated with R-CHOP

Cited by 14 publications

References 39 publications

New developments in the pathology of malignant lymphoma: a review of the literature published from May 2015–September 2015

New developments in the pathology of malignant lymphoma: a review of the literature published from May 2015–September 2015

Anti-carbamylated protein antibodies in rheumatoid arthritis patients and their association with rheumatoid factor

DNMT1 is predictive of survival and associated with Ki-67 expression in R-CHOP-treated diffuse large B-cell lymphomas

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