This study sought to determine the effects of HIV-associated neurocognitive disorders (HAND) on health literacy, which encompasses the ability to access, understand, appraise, and apply healthrelated information. Participants included 56 HIV seropositive individuals, 24 of whom met Frascati criteria for HAND, and 24 seronegative subjects who were comparable on age, education, ethnicity, and oral word reading. Each participant was administered a brief battery of wellvalidated measures of health literacy, including the Expanded Numeracy Scale (ENS), Newest Vital Sign (NVS), Rapid Estimate of Adult Literacy in Medicine (REALM), and Brief Health Literacy Screen (BHLS). Results revealed significant omnibus differences on the ENS and NVS, which were driven by poorer performance in the HAND group. There were no significant differences on the REALM or the BHLS by HAND status. Among individuals with HAND, lower scores on the NVS were associated with greater severity of neurocognitive dysfunction (e.g., NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript working memory and verbal fluency) and self-reported dependence in activities of daily living. These preliminary findings suggest that HAND hinders both fundamental (i.e., basic knowledge, such as numeracy) and critical (i.e., comprehension and application of healthcare information) health literacy capacities, and therefore may be an important factor in the prevalence of health illiteracy. Health literacy-focused intervention may play an important role in the treatment and health trajectories among persons living with HIV infection.
KeywordsHIV-associated neurocognitive disorders; Neuropsychology; Disability; Health literacy Health literacy has been broadly defined as "the degree to which individuals have the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions [1]." A recent systematic review by Berkman et al. [2] found considerable evidence that lower health literacy increases risk of suboptimal health outcomes, including more hospitalizations, reduced utilization of preventative medicine, and non-adherence to prescribed medications. Health literacy may play a particularly important role in health outcomes for underserved populations with chronic medical conditions, such as HIV disease [3]. It is estimated that between 20 and 40 % of persons infected with HIV have low health literacy [4], usually defined as self-reported difficulties with understanding healthcare materials or poor performance on validated measures of medical word knowledge or comprehension (e.g., Rapid Estimates of Adult Literacy in Medicine (REALM)). Specifically, HIV-related low health literacy is associated with limited knowledge of HIV disease [5] and refusal of HIV testing [6]. In the setting of HIV disease, low health literacy is particularly prevalent among ethnic and racial minorities and persons with lower levels of educational attainment [7]. HIV-infected persons with lower health literacy a...