Low-Gravity Fluid Dynamics and Transport Phenomena

Koster, Jean N.; Sani, R. L.

doi:10.2514/4.866036

Cited by 10 publications

(2 citation statements)

References 39 publications

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“…microneedle-based transdermal 65 ). 66 and fluid dynamics 67 , in altered gravity; operation will need to be compliant across microgravity for in-flight production and reduced gravity for a Moon or Mars mission. There is a growing body of literature on development of bioreactors with alternative containment and mixing for microgravity [68][69][70] .…”

Section: Comparing Molecular Medical Foundries For Spacementioning

confidence: 99%

Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond

McNulty¹,

Xiong

Yates

et al. 2020

Preprint

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Space missions have always assumed that the risk of spacecraft malfunction far outweighs the risk of human system failure. This assumption breaks down for longer duration exploration missions and exposes vulnerabilities in space medical system. Space agencies can no longer buy down the majority of human system risk through the crew member selection process and emergency re-supply or evacuation. No mature medical solutions exist to close the risk gap. With recent advances in biotechnology, there is promise in augmenting a space pharmacy with a biologically-based space foundry for on-demand manufacturing of high-value medical products. Here we review the challenges and opportunities of molecular pharming, the production of pharmaceuticals in plants, as the basis of a space medical foundry to close the risk gap in current space medical systems. Plants have long been considered an important life support object in space and can now also be viewed as programmable factories in space. Advances in molecular pharming-based space foundries will have widespread application in promoting simple and accessible pharmaceutical manufacturing on Earth.

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Section: Comparing Molecular Medical Foundries For Spacementioning

confidence: 99%

Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond

McNulty¹,

Xiong

Yates

et al. 2020

Preprint

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show abstract

“…Two categories of experiments have been designed to address this question: one in which small numbers of large (15 x 40 cm) membranes are cast on orbit 186 ' 187 and one in which several small (0.64-cm-diam) membranes can be cast using low-cost, low-volume hardware 179 on orbit, in low-gravity aircraft, or on sounding rockets. Two categories of experiments have been designed to address this question: one in which small numbers of large (15 x 40 cm) membranes are cast on orbit 186 ' 187 and one in which several small (0.64-cm-diam) membranes can be cast using low-cost, low-volume hardware 179 on orbit, in low-gravity aircraft, or on sounding rockets.…”

Section: Polymer Film Formation In Low Gravitymentioning

confidence: 99%

Separation Physics

1990

Low-Gravity Fluid Dynamics and Transport Phenomena

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Nomenclature A = cross-sectional area of electrophoresis or extraction chamber A M = surface area of separand molecule of particle a -particle radius B = constant of proportionality for partition coefficient b = half thickness of FFE chamber b tj = monomer interaction coefficients C(x) = concentration of density solute in density gradient C f = concentration of the ith solute C fj = osmotic virial coefficient c = concentration of solute D = diffusion coefficient E = electric field strength e = charge on the electron g = acceleration of Earth's gravity Hj = Hjerten number 7 = electric current J t = flow of ith substance K = dissociation constant k = electrical conductivity k,l = coordinates of the sample zone center in horizontal rotation k B -Boltzmann constant L = number of species M = molecular weight m = dimensionless molality N = number of monomers per polymer molecule

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Analytical estimates of radial segregation in Bridgman growth from low-level steady and periodic accelerations

Naumann

Baugher

1992

Journal of Crystal Growth

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Low-Gravity Fluid Dynamics and Transport Phenomena

Cited by 10 publications

References 39 publications

Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond

Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond

Separation Physics

Analytical estimates of radial segregation in Bridgman growth from low-level steady and periodic accelerations

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