Low‐Grade Systemic Inflammation Profile, Unrelated toHomocysteinemia, in Obese Children

Economou, Emmanuel; Malamitsi‐Puchner, Ariadne; Pitsavos, C; Kouskouni, Evangelia; Magaziotou-Elefsinioti, Ioanna; Creatsas, George

doi:10.1155/mi.2005.337

Cited by 13 publications

(8 citation statements)

References 29 publications

(48 reference statements)

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“…However, one study (24) found little utility for SAA as a marker of obesity-related inflammation, which we suggest may be due to the prepubertal status of their cohort (children <10 y). This lack of effect was also described by Neuman et al (25), however, the BMIs of their study groups were similar, and would therefore display a similar level of obesity-related inflammation.…”

Section: Discussionmentioning

confidence: 67%

“…To our knowledge, only three studies have examined SAA in children. In the first, the authors found that SAA was not affected by the presence of increased weight, which we suggest may due to the young age of their prepubertal children (<10 y) (24). In a second study, both groups were obese, therefore limiting the likelihood of identifying any differences in SAA (25).…”

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confidence: 73%

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High-density lipoprotein subfractions display proatherogenic properties in overweight and obese children

et al. 2013

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Background:In adults, obesity-driven inflammation can lead to increased cardiovascular disease (CVD). However, information regarding childhood obesity and its inflammatory sequelae is less well defined. Serum amyloid-A (SAA) is an inflammatory molecule that rapidly associates with highdensity lipoproteins (HDLs) and renders them dysfunctional. Therefore, SAA may be a useful biomarker to identify increased CVD potential in overweight and obese children. Methods: Young Hearts 2000 is a cross-sectional cohort study in which 92 children who were obese were matched for age and sex with 92 overweight and 92 lean children. HDL 2 and HDL 3 (HDL 2&3 ) were isolated from plasma by a three-step rapid-ultracentrifugation procedure. SAA was measured in serum and HDL 2&3 by an enzyme-linked immunosorbent assay procedure, and the activities of cholesterol ester transfer protein (CETP) and lecithin cholesteryl acyltransferase (LCAT) were measured by fluorimetric assays. results: Trends across the groups indicated that SAA increased in serum and HDL 2&3 as BMI increased, as did HDL 2 -CETP and HDL 2 -LCAT activities. conclusion: These results have provided evidence that overweight and obese children are exposed to an inflammatory milieu that impacts the antiatherogenic properties of HDL and that could increase CVD risk. This supports the concept that it is important to target childhood obesity to help minimize future cardiovascular events.

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Section: Discussionmentioning

confidence: 67%

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confidence: 73%

High-density lipoprotein subfractions display proatherogenic properties in overweight and obese children

et al. 2013

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“…The underlying mechanism for the obesity-asthma link remains controversial. Factors stemming from obesity including greater systemic inflammation (36)(37)(38)(39), gastro-esophageal reflux (40)(41)(42)(43), obstructive sleep apnea (44)(45)(46), and reduced lung volumes (47,48) 47;48 are all plausible mechanisms. In addition, it is unclear how accurately and consistently various physicians diagnose asthma (49).…”

Section: Discussionmentioning

confidence: 99%

Body Mass Index-Percentile and Diagnostic Accuracy of Childhood Asthma

2009

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Referring physicians do not appear to erroneously diagnose children with asthma due to overweight status. Our data confirm that overweight status is extremely high in children with true asthma and likely increases the risk for true asthma. Although these data cannot discern causality, high BMI-percentile is associated with greater airflow obstruction and elevated markers of systemic inflammation that could contribute to underlying mechanisms of asthma.

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“…216 Other factors such as white blood cells and serum amyloid A have also emerged as additional downstream markers of inflammation. However, the data are not conclusive 58,108,139,219 and to date have not supplied additional predictive power above that of CRP, IL-6, and TNF-␣.…”

Section: Inflammation Beyond Crpmentioning

confidence: 95%

Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth

Balagopal¹,

Ferranti²,

Cook³

et al. 2011

Circulation

296

239

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Abstract-The rapid increase in the prevalence and severity of obesity in children is likely to lower the age of onset and increase the incidence of cardiovascular disease worldwide. Understanding the pathophysiology and improving the clinical management of cardiovascular disease involve a knowledge of novel risk factors and biomarkers. The clinical and mechanistic roles of these novel biological factors during childhood are currently being investigated. The goals of this scientific statement are to present the existing knowledge and theoretical framework of nontraditional risk factors for cardiovascular disease as they relate to children and adolescents, to describe the relevance and weight of available experimental and clinical evidence and the therapeutic implications pertaining to nontraditional risk factors in the pediatric population, and to stimulate further research with a goal of developing valid and reliable approaches to identify and validate novel risk factors that will aid in the clinical evaluation and perhaps prediction of cardiovascular disease in the pediatric population. Although several biomarkers are promising, substantial research is required before nontraditional risk factors can be used to identify and reduce cardiovascular disease risk in children and adolescents. (Circulation. 2011;123:2749-2769.)

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Low‐Grade Systemic Inflammation Profile, Unrelated toHomocysteinemia, in Obese Children

Cited by 13 publications

References 29 publications

High-density lipoprotein subfractions display proatherogenic properties in overweight and obese children

High-density lipoprotein subfractions display proatherogenic properties in overweight and obese children

Body Mass Index-Percentile and Diagnostic Accuracy of Childhood Asthma

Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth

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