Low-grade sinonasal sarcoma with neural and myogenic features—diagnostic challenge and pathogenic insight

Powers, Kathleen A.; Han, Lucy; Chiu, Alexander G.; Aly, Fatima Zahra

doi:10.1016/j.oooo.2014.10.007

Cited by 35 publications

(41 citation statements)

References 14 publications

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“…Under electron microscopy, Lewis et al 3 noted the presence of moderate amounts of intermediate filaments and rough, endoplasmic reticulum with occasional subplasmalemmal filaments and dense bodies in the tumor cells; specialized organelles were seen in myogenic cells. This latter finding was not observed by Powers et al, 4 suggesting a fibroblastic differentiation. Only 2 cases in the Lewis et al 3 series were processed for cytogenetic analysis.…”

Section: Immunohistochemical and Ultrastructural Studiesmentioning

confidence: 47%

“…3 Unlike other sarcoma subtypes, LGSSNMF has low positron emission tomography activity, which is not helpful for the diagnosis of this lesion. 4 …”

Section: Clinical and Radiologic Featuresmentioning

confidence: 99%

“…3 However, Powers et al 4 demonstrated that LGSSNMF can show fibroblastic differentiation, rather than the myogenic differentiation, with positive staining for caldesmon and b-catenin, and negative staining for SMA and muscle-specific actin. Under electron microscopy, Lewis et al 3 noted the presence of moderate amounts of intermediate filaments and rough, endoplasmic reticulum with occasional subplasmalemmal filaments and dense bodies in the tumor cells; specialized organelles were seen in myogenic cells.…”

Section: Immunohistochemical and Ultrastructural Studiesmentioning

confidence: 99%

“…To our knowledge, this is the only case series of LGSSNMF reported in the literature. In 2015, an additional case of this new entity with a different immunophenotype was reported by Powers et al, 4 and an etiopathogenic hypothesis was proposed. Clinically, LGSSNMF demonstrates a predilection for women (sex ratio, 0.33), with a mean age of 52 years.…”

mentioning

confidence: 97%

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Low-Grade Sinonasal Sarcoma With Neural and Myogenic Features: A Recently Discovered Entity With Unique Features and Diagnostic Challenge

Triki¹,

Ayadi²

2017

Archives of Pathology &Amp; Laboratory Medicine

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Low-grade sinonasal sarcoma with neural and myogenic features is an entity recently described in the literature. Little is known about its etiopathogenesis, natural history, or optimal treatment. In fact, it has relatively unique findings: it has a distinctive cytogenetic signature, and it expresses both smooth muscle actin and S100 protein. However, its diagnosis is challenging on biopsies showing negative staining for these 2 markers. The differential diagnoses include fibrosarcoma, malignant peripheral nerve sheath tumors, and other benign and malignant lesions. A complete resection, with or without radiotherapy, is required because this lesion appears to be locally aggressive. However, the clinical outcome seems to be good. Low-grade sinonasal sarcoma with neural and myogenic features merits classification as an independent tumor in the next World Health Organization classification of head and neck tumors. Reports of additional cases are required to support its unique classification.

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Section: Immunohistochemical and Ultrastructural Studiesmentioning

confidence: 47%

“…3 Unlike other sarcoma subtypes, LGSSNMF has low positron emission tomography activity, which is not helpful for the diagnosis of this lesion. 4 …”

Section: Clinical and Radiologic Featuresmentioning

confidence: 99%

Section: Immunohistochemical and Ultrastructural Studiesmentioning

confidence: 99%

mentioning

confidence: 97%

See 2 more Smart Citations

Low-Grade Sinonasal Sarcoma With Neural and Myogenic Features: A Recently Discovered Entity With Unique Features and Diagnostic Challenge

Triki¹,

Ayadi²

2017

Archives of Pathology &Amp; Laboratory Medicine

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“…The same group subsequently renamed the entity biphenotypic sinonasal sarcoma (BSNS) [50]. Thirty-six cases of BSNS have been reported [49][50][51][52]. They typically arise in the superior aspects of the nasal cavity and ethmoid sinuses of women (M:F ratio is 1:3) ranging in age from 24 to 85 (mean 52).…”

Section: Biphenotypic Sinonasal Sarcomamentioning

confidence: 99%

Newly Described Tumor Entities in Sinonasal Tract Pathology

Bishop

2016

Head and Neck Pathol

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Surgical pathology of the sinonasal tract (nasal cavity and paranasal sinuses) is extremely challenging due in part to the tremendous diversity of tumor types that may arise in this region. Compounding the difficulty, a number of new sinonasal tumor entities have been recently described, and pathologists may not yet be familiar with these neoplasms. This manuscript will review the clinicopathologic features of some of the newly described sinonasal tumor types: NUT midline carcinoma, HPV-related carcinoma with adenoid cystic-like features, SMARCB1 (INI-1) deficient sinonasal carcinoma, biphenotypic sinonasal sarcoma, and renal cell-like adenocarcinoma.Keywords NUT midline carcinoma Á HPV-related carcinoma with adenoid cystic-like features Á SMARCB1 (INI-1) deficient sinonasal carcinoma Á Biphenotypic sinonasal sarcoma Á Renal cell-like adenocarcinoma

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