Low-Grade Myofibroblastic Sarcoma of the Larynx: Case Report and Review of Literature

Kordač, Petr; Nikolov, Dimitar Hadži; Smatanová, Katarína; Kalfeřt, David

doi:10.14712/18059694.2015.82

Cited by 15 publications

(7 citation statements)

References 19 publications

(20 reference statements)

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“…Surgery is the primary treatment modality for LGMS. [ 36 ] Because LGMS may have a tendency for invasive growth and local recurrence, an extensive surgical margin should be recommended, [ 37 ] although in our case, the mass was completely encapsulated. Complete resection of the primary lesion and local recurrent lesions is essential, but the optimal extent of resection has yet to be determined.…”

Section: Discussionmentioning

confidence: 97%

“…[ 42 ] Nodular fasciitis is less cellular and uniform than LGMS, and has a heterogeneous appearance with cellular, myxoid, and fibrous areas. [ 37 ] Fibromatosis may display a prominent nodularity, and tends to infiltrate adjacent tissues. [ 37 ] The tumor cells are lacking of atypia and mitotic figures, and are positive only for vimentin.…”

Section: Discussionmentioning

confidence: 99%

“…[ 37 ] Fibromatosis may display a prominent nodularity, and tends to infiltrate adjacent tissues. [ 37 ] The tumor cells are lacking of atypia and mitotic figures, and are positive only for vimentin. [ 20 ] Finally, LGMS is most easily confused with IMT.…”

Section: Discussionmentioning

confidence: 99%

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Low-grade myofibroblastic sarcoma of the orbit

Zhang¹,

et al. 2017

Medicine

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Rationale:Low-grade myofibroblastic sarcoma (LGMS) is a malignant lesion composed of myofibroblasts. It is an uncommon tumor of unknown etiology that mainly develops in the bone or soft tissue and is most often reported in the head and neck, particularly in the tongue and oral cavity.Patient concerns:A 2-year-old girl, previously well and with no significant medical history or family history of other diseases, presented with a 2-week painless swelling of the right orbit.Diagnoses:Preoperative computed tomography (CT) revealed a large homogeneous enhanced mass, 21 × 13 mm in size, located on lateral wall of the right orbit with bone absorption. The mass was resected and histopathological examination revealed LGMS of the orbit.Interventions:On May 2016, she underwent surgery without the additional postoperative treatment.Outcomes:The patient's postoperative course was uneventful, and was discharged on the 6th day after surgery. During a year follow-up period, there was no recurrence of the postoperative CT. The patient and her family were satisfied with the result of the surgery.Lessons:Based on clinical characteristics and postoperative CT, we considered the mass may be a benign tumor. We completely resected along the capsule without an extensive surgical margin. However, postoperative histopathology diagnose LGMS, which shows a strong potential for local recurrence and vascular invasion. So we should close observation of the patient's symptoms and sign. If the tumor has invaded adjacent tissues, we will use adjuvant chemotherapy or radiotherapy.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Low-grade myofibroblastic sarcoma of the orbit

Zhang¹,

et al. 2017

Medicine

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“…Non-English literature [6] 1 28 0/1 Head&neck 1 S 1 R 1 Roth et al [7] 1 46 0/1 Trunk 1 S 1 NR 1 San Miguel et al [8] 1 51 0/1 Extremity 1 S 1 NR 1 Morgan et al [9] 1 46 0/1 Trunk 1 S 1 NR 1 Tajima et al [10] 1 64 0/1 Trunk 1 S 1 NA 1 Laco et al [11] 1 24 0/1 Head&neck 1 S 1 NR 1 Takahama et al [12] 1 42 1/0 Head&neck 1 RT, CTX 1 DOD 1 Meng et al [13] 14 30. [14] 1 44 1/0 Head&neck 1 S 1 NR 1 Meng et al [15] 3 34 3/0 Head&neck 3 S, RT 3 R 3 Jay et al [16] 1 41 1/0 Head&neck 1 S 1 NR 1 Eisenstat et al [17] 1 5 0/1 Trunk 1 sudden death NA 1 Agaimy et al [18] 2 60-70 0/2 Trunk 2 S 2 R 2 Nagata et al [19] 1 36 1/0 Extremity 1 S 1 NR 1 Morii et al [20] 1 46 0/1 Trunk 1 S 1 NR 1 Demarosi et al [21] 2 56 1/1 Head&neck 2 S 2 NR 2 Niedzielska et al [22] 1 54 1/0 Head&neck 1 S 1 NR 1 Arora et al [23] 1 38 0/1 Extremity 1 S 1 NR 1 Humphries et al [24] 1 15 0/1 Trunk 1 S 1 NA 1 Montebugnoli et al [25] 1 37 1/0 Head&neck 1 S 1 NR 1 Miyazawa et al [26] 1 65 1/0 Trunk 1 S 1 NR 1 Ni et al [27] 1 41 0/1 Head&neck 1 S 1 NR 1 Yamada et al [28] 1 73 1/0 Head&neck 1 S 1 NR 1 Khosla et al [29] 1 55 1/0 Head&neck 1 S, RT 1 NR 1 Murakami et al [30] 1 24 0/1 Trunk 1 S 1 NR 1 Saito et al [31] 1 50 0/1 Extremity 1 S 1 NR 1 Cai et al (2013) [32] 2 30.5 2/0 Head&neck 2 S 2 NR 2 Oylumlu et al [33] 1 36 1/0 Trunk 1 S, CTX 1 Cardiac metastasis Kordač et al [34] 1 40 1/0 Head&neck 1 S 1 NR 1 Qiu et al [35] 2 37 1/1 Head&neck 2 S 2 NR 1 R 1 Han et al [36] 1 26 1/0 Head&neck 1 S 1 NR 1 Myong et al [37] 1 61 0/1 Trunk 1 S 1 NR 1 Maruyama et al [38] 1 43 0/1 Head&neck 1 S 1 NR 1 Hadjigeorgiou et al [39] 1 55 1/0 Trunk 1 ...…”

Section: Discussionmentioning

confidence: 99%

Low-grade myofibroblastic sarcoma of the proximal femur: A case report and literature review

Gao

Wang

et al. 2022

Medicine

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Rational: Low-grade myofibroblastic sarcoma (LGMS) is an atypical type of tumor composed of myofibroblasts. LGMS in the femoral head neck junction is extremely rare and no case treated by hip arthroscopy was reported. Patient concerns: We reported a case of LGMS in the femoral head neck junction treated by hip arthroscopy. A 30-year-old female was admitted to our hospital with discomfort and pain after left hip sprained one year prior. Physical examination revealed swelling of the left hip and magnetic resonance images showed a soft tissue mass in the femoral head neck junction. Diagnosis: Via microscopy of pathological specimens, spindle cell proliferative lesions, atypia of some cells, and mitotic figures/pathological mitotic figures of some cells were observed. Immunohistochemistry revealed positive for smooth muscle actin, focally positive for CD34 and CD68, while negative for S-100, desmin, and anaplastic lymphoma kinase. The imaging, histomorphological and immunohistochemical features suggested a final diagnosis of LGMS of the proximal femur. Interventions: This patient underwent hip arthroscopy for excision of the soft tissue mass. Outcomes: The clinical and imaging follow-up at 6 months postoperatively showed that surgery had achieved good clinical outcomes. Lessons: To the best of our knowledge, this is the first case report of LGMS in the femoral head neck junction treated by hip arthroscopy. Beyond the present case, other 120 cases from 58 literatures (1998–2022) are reviewed and discussed. The age of LGMS patients ranged from 11 months to 77 years and the male-to-female ratio was approximately 1.28:1. The location distribution of previously reported LGMS cases and the present case was as follows: Head&neck (45.90%), trunk (30.33%), and extremity (23.77%). Hip arthroscopic excision of LGMS may achieve relatively good clinical outcomes.

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“…Due to the invasive nature and high recurrence potential of this tumor, extended surgical excision involving healthy margins is the most effective treatment [8,14,15]. Other treatments such as radiotherapy and chemotherapy have also been attempted.…”

Section: Discussionmentioning

confidence: 99%

Low-grade myofibroblastic sarcoma: a case report of a child

Hamon¹,

Bourkis

Toux³

2019

J Oral Med Oral Surg

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Introduction: Myofibroblastic sarcomas are malignant tumors characterized by the increased proliferation of myofibroblasts; they are rare and have been recently discovered. Observation: A 14-year-old adolescent had a large lesion in the inside of her right mandible. The diagnosis, after a difficult histological analysis, was low-grade myofibrosarcoma. The patient was treated with non-interruptive hemimandibulectomy. Discussion: Low-grade myofibroblastic sarcoma is one of four types of myofibroblastic sarcomas recognized by the WHO in the 2001 classification. This classification allows us to determine a prognosis based on histological characteristics of the lesion. Conclusion: In all cases of low-grade myofibroblastic sarcoma, the preferred treatment is curative surgical resection; but still poses a problem in the prosthetic rehabilitation of oral lesion.

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Low-Grade Myofibroblastic Sarcoma of the Larynx: Case Report and Review of Literature

Cited by 15 publications

References 19 publications

Low-grade myofibroblastic sarcoma of the orbit

Low-grade myofibroblastic sarcoma of the orbit

Low-grade myofibroblastic sarcoma of the proximal femur: A case report and literature review

Low-grade myofibroblastic sarcoma: a case report of a child

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