Low-grade myofibroblastic sarcoma of the vulva

Roth, Ted M.; Fratkin, Jonathan D.; Woodring, Thomas; McGehee, Ramon

doi:10.1016/j.ygyno.2003.09.035

Cited by 20 publications

(9 citation statements)

References 5 publications

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“…However, problems with differentiation between sarcoma subgroups have been described in the literature with the most common locations being the oral cavity (tongue) followed by the limbs, pelvis, lungs and breasts, with a predilection for soft, perifascial and subcutaneous tissues [2]-[4]. Other locations have also been described: the salivary gland [5], nasal skin [6] and the vulva [7]. Painless growth of a large mass is typical of intraosseous tumours [8].…”

Section: Discussionmentioning

confidence: 99%

Low-grade myofibroblastic sarcoma of the mandible: a case report

Niedzielska

Janic

Mrowiec³

2009

J Med Case Rep

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IntroductionLow-grade myofibroblastic sarcoma is a rare entity, which mostly develops in the soft tissues of the head and neck. Within the oral cavity lingual lesions are the most common. It tends to recur locally rather than to metastasise.Case presentationWe present a 54-year-old man with a one-year history of buccal oedema. He also had arterial hypertension and clinical examination revealed distension of the left mandibular ramus with laminar deflection in the area of the retromolar triangle.ConclusionWe present a rare intramandibular encapsulated lesion that caused diagnostic difficulties. Our diagnostic methods included immunohistochemistry and molecular investigations. We emphasise the uncommon location of this tumour type.

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Section: Discussionmentioning

confidence: 99%

Low-grade myofibroblastic sarcoma of the mandible: a case report

Niedzielska

Janic

Mrowiec³

2009

J Med Case Rep

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“…1,2 The oral cavity is the most frequent site of the tumor development, followed in order by the extremities, pelvis, lung, mammary gland, salivary gland and perineum. 1,2,[8][9][10][11][12] Development of the tumor in the retroperitoneum, as seen in our patient, is extremely rare. In the literature, there is not more than 7 cases reported.…”

Section: Discussionmentioning

confidence: 96%

Low-grade myofibroblastic sarcoma of retroperitoneum: a rare case

et al. 2019

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Low-grade myofibroblastic sarcoma (LGMFS) is an uncommon tumor which develops mainly in the bone or soft tissues of the head and neck region, trunk, or extremities and extremely rarely found in the abdominal cavity. The rarity of the disease and its low-grade features make an accurate diagnosis difficult in most cases. We recently encountered a giant LGMFS which had developed in retroperitoneum and surgically resected with gratifying results. An 18 years old female presented with complaint of left sided abdominal pain since 8 months and left sided abdominal lump since 5 months. Imaging examinations revealed retroperitoneal soft tissue mass, and surgical treatment was scheduled. During operation, a tumor about 20x18x15cm in diameter with its anterior aspect covered with the pancreas, mesocolon and splenic flexure of colon with densely adhered to splenic vessels and left renal vessels was found. The tumor had firm adhesions to the surrounding tissues, and it was excised with concomitant distal pancreato-splenectomy, left nephrectomy and resection of splenic flexure of colon with colo-colic anastomosis. Histopathologically, fusiform cells were arranged in a complicated or storiform pattern, and immunohistochemical staining revealed that the tumor was positive for vimentin and focally positive for α-smooth muscle actin (SMA), negative for desmin, CD34, CD117, EMA, DOG-1 and S-100. Diagnosis of LGMFS was made. During 6 months follow up patient is asymptomatic and ultrasound abdomen is normal. In case of LGMFS, favorable prognosis can be attained by complete resection of the primary lesion and regular follow up of patient by physical examination and imaging modality.

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“…LGMS is known to be a rare sarcoma tumor (1)(2)(3). In the head and neck region, LGMS frequently occurs in the tongue, especially in the lateral edge of the tongue (13) compared with that in the skin and gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

Low‑grade myofibroblastic sarcoma arising in the tip of the tongue with intravascular invasion: A case report

et al. 2018

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Abstract. Low-grade myofibroblastic sarcoma (LGMS) is a rare intermediate tumor, which rarely metastasizes and has myofibroblastic differentiation in various sites. It is particularly associated with the tongue in the head and neck region. The lack of any pathological features means it is difficult to make a conclusive diagnosis of LGMS. The immunohistochemical features and genomic rearrangements, including SS18-SSXs and MYH9-USP6s and the genetic mutations of cancer-associated genes, including APC, CTNNB1, EGFR, KRAS, PIK3CA and p53 were examined in a case of LGMS arising in the tip of the tongue. Immunohistochemically, the tumor cells were positive for alpha-smooth muscle actin and vimentin, as in previous reports. They demonstrated neither genomic rearrangements nor point mutations of cancer-associated genes. Although several tumor cells demonstrated intravascular invasion, the MIB-l labeling index of the cells was the same as the original lesion. To the best of our knowledge, this is the first case report of LGMS arising in the tip of the tongue with intravascular invasion.

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Low-grade myofibroblastic sarcoma of the vulva

Cited by 20 publications

References 5 publications

Low-grade myofibroblastic sarcoma of the mandible: a case report

Low-grade myofibroblastic sarcoma of the mandible: a case report

Low-grade myofibroblastic sarcoma of retroperitoneum: a rare case

Low‑grade myofibroblastic sarcoma arising in the tip of the tongue with intravascular invasion: A case report

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