Low Grade Malignant Proliferating Pilar Tumor Arising from Breast Skin Simulating Squamous Cell Carcinoma, a Case Report

Akrami, Majid; Talei, Abdolrasoul; Nazemzadegan, Bahman; Abdollahi, Ahmad; Aslani, Fatemeh Sari; Safaei, Akbar; Tahmasebi, Sedigheh

doi:10.1007/s13193-013-0275-2

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Benign and malignant PTTs most commonly arise in areas with dense hair population, 90% on the scalp; however, these tumors have been reported on other locations such as the back, vulva, buttock, and even chest. [15][16][17] Owing to no prospective randomized control trials and exceedingly rarity of cases in the literature, no clear consensus has been established on diagnosis or management. Our study represents the only and most comprehensive systematic review of MPTTs of the scalp.…”

Section: Study Characteristicsmentioning

confidence: 99%

Malignant Proliferating Trichilemmal Tumor of the Scalp: A Systematic Review

Osto

Parry

Rehman

et al. 2021

The American Journal of Dermatopathology

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Objectives: Malignant proliferating trichilemmal tumors of the scalp can exhibit aggressive presentation and recurrences. Our objective was to perform an evidence-based systematic review evaluating clinical presentation, tumor characteristics, and treatment modalities used to determine which treatment strategies had the best outcomes. Methods:The databases PubMed, Embase, and Cochrane Library were searched for relevant literature by the authors. Patient demographics, imaging, treatments, and other clinical characteristics were obtained. The results were reported using the Preferred Reporting Systems for Systematic Reviews and Meta-Analysis guidelines.Results: Thirty-nine studies with a total of 65 patients were identified. The most common presentation was a history of slowgrowing, painless swollen mass on the scalp. In total, 10 patients (15.4%) presented with spread to the regional lymph nodes and 6 (9.2%) additional patients presented with metastasis to distant locations. In total, 61 patients (93.8%) underwent surgery. Various chemotherapy and radiation therapy regimens were used. Of the 45 cases with documented follow-up, 11 (24.4%) patients had one or multiple instances of local, lymph node or metastatic tumor recurrence.Conclusions: Surgery is favored, and the exact approach should be based on clinical judgment. However, Mohs micrographic surgery should strongly be considered because of its superior margin control against such an invasive tumor. Radiotherapy and chemotherapy have been used as adjuvant therapy in aggressive cases or recurrence. Patients should be followed closely and examined often to frequently assess recurrence or metastasis. Randomized controlled trials are needed to further clarify these findings.

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Section: Study Characteristicsmentioning

confidence: 99%

Malignant Proliferating Trichilemmal Tumor of the Scalp: A Systematic Review

Osto

Parry

Rehman

et al. 2021

The American Journal of Dermatopathology

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“…Decreased expression of p53, which is responsible for the repair of DNA damage, and increased expression of Ki-67, which indicates a high rate of mitosis in the cell, have been associated with malignant transformation and high recurrence rates (33)(34)(35). In a review of the literature, 93 well-documented cases of MPTTs were found, beyond our case (36)(37)(38)(39)(40)(41). Furthermore, differential diagnosis between MPTTs and other skin cancer with squamous differentiation, including both squamous cell carcinoma and adnexal neoplasms with squamous differentiation can be challenging (42).…”

Section: Discussionmentioning

confidence: 65%