Low-grade intraductal carcinoma of salivary glands: A systematic review of this rare entity

Giovacchini, Francesco; Bensi, Caterina; Belli, Stefano; Laurenti, Maria Elena; Mandarano, Martina; Paradiso, Daniele; Giansanti, Michele; Tullio, A

doi:10.1016/j.jobcr.2018.11.003

Cited by 22 publications

(37 citation statements)

References 31 publications

(33 reference statements)

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“…Distinguishing between SC and intercalated IDC can be challenging, as both entities share histological, cytological, and immunohistochemical (expression of S100, SOX10 & mammaglobin) features (36)(37)(38)(39) (7,40). In our study, mammaglobin expression is shared by SC and intercalated IDC (83.3% and 85.7%, respectively), while MUC4 was restricted to SC (all 30 IDCs were negative).…”

Section: Accepted Articlementioning

confidence: 61%

MUC4 is a valuable marker for distinguishing secretory carcinoma of the salivary glands from its mimics

et al. 2020

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Background: Secretory carcinoma (SC; synonym: mammary analogue SC= MASC) is a lowgrade salivary gland tumor which occurs both in major and in minor salivary glands. SC is known for its wide morphological, architectural and immunohistochemical spectrum, that overlaps with several salivary gland neoplasms, including acinic cell carcinoma (AciCC) and intraductal carcinoma (IDC) of intercalated type in major, and polymorphous adenocarcinoma (PAC) in minor salivary glands. These tumors share with SC some morphological features, SOX10 immunoreactivity, and, with the exception of AciCC, they all coexpress S100 and mammaglobin. Methods: We compare MUC4 and mammaglobin Accepted Article This article is protected by copyright. All rights reserved expression in 125 salivary gland carcinomas (54 genetically confirmed SCs, 20 AciCCs, 21 PACs, and 30 IDCs) to evaluate its potential in differentiating these entities. Results: Moderate to strong diffuse MUC4 positivity was detected in 49 SCs (90.7%) compared to none of IDCs and PACs. On the contrary, mammaglobin is frequently expressed in SC (30 of 36 cases; 83.3%), IDC (24/28; 85.7%) and PAC (7/19; 36.8%). Two of 3 high grade SCs lost MUC4 expression in the high-grade tumor component. No significant correlation was found between MUC4 expression and the fusion variant in SC (ETV6-NTRK vs. non-ETV6-NTRK). Conclusion: The results of our study identify MUC4 as a sensitive (90.7%) and specific (100%) marker for SC, with high positive (100%) and negative (93.4%) predictive values. Thus, MUC4 may be used as a surrogate for SC in limited biopsy material and in cases with equivocal morphology.

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Section: Accepted Articlementioning

confidence: 61%

MUC4 is a valuable marker for distinguishing secretory carcinoma of the salivary glands from its mimics

et al. 2020

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“…Low-grade cribriform cystadenocarcinoma and salivary duct carcinoma in situ were previously categorized as “low-grade salivary duct carcinoma”; however, they have now been collectively categorized as intraductal carcinomas; low-grade and high-grade, respectively [ 1 , 4 ]. Intraductal carcinomas are rare salivary gland malignancies that most frequently affect the parotid gland and are only rarely noted at other sites [ 2 ]. They are not particularly aggressive and do not commonly invade the surrounding tissues.…”

Section: Discussionmentioning

confidence: 99%

“…They are not particularly aggressive and do not commonly invade the surrounding tissues. The tumor mass also grows slowly and facial nerve involvement is rare [ 2 , 4 , 5 ]. Giovacchini et al [ 2 ] summarized 54 cases of intraductal carcinoma; however, due to the small number of cases, no statistical significance was observed.…”

Section: Discussionmentioning

confidence: 99%

“…Intraductal carcinomas were first described by Delgado et al [ 1 ] in 1996 as “low-grade salivary duct carcinomas.” In the past they have been variously referred to as “low-grade salivary duct carcinoma,” “low-grade cribriform cystoadenocarcinoma,” or “salivary duct carcinoma in situ” [ 2 , 3 ]. They were reclassified as intraductal carcinomas by the 4th WHO Classification of Head and Neck Tumors in 2017 [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…They were reclassified as intraductal carcinomas by the 4th WHO Classification of Head and Neck Tumors in 2017 [ 4 ]. This form of carcinoma is a rare salivary gland tumor that most frequently affects the parotid gland (80.4%), while being only rarely noted at other sites [ 2 ]. No cases growing from the parapharyngeal space have been reported to date.…”

Section: Introductionmentioning

confidence: 99%

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Intraductal Carcinoma of the Parotid Gland Presenting as Parapharyngeal Mass

et al. 2020

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Intraductal carcinomas are rare, malignant tumors that arise from the salivary glands. They commonly grow from the parotid gland and no cases growing from the parapharyngeal space have been reported to date. We report a 76-year-old man who was inadvertently found to have a parapharyngeal lesion by CT scans and MR imaging. The tumor was resected through an upper neck approach and diagnosed histopathologically as intraductal carcinoma. As far as we are aware, this is the first case of intraductal carcinoma arising from the parapharyngeal space. Here, we describe the management of this disease together with a review of the relevant literature.

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Cytomorphologic features of intraductal salivary gland carcinoma: A multi‐institutional study of 13 FNA cases with histologic, molecular, and clinical correlations

Viswanathan

Sadow

Maleki

et al. 2021

Cancer Cytopathology

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BACKGROUND: Intraductal carcinoma of the salivary gland (IDC) is a rare cancer with potential actionable targets, including RET fusions. Histologic and molecular features of IDC were recently reported, but cytomorphologic data are limited. In the largest multi-institutional fine-needle aspiration (FNA) series, the authors describe the cytomorphologic features of 13 IDC cases with available clinical, radiologic, histopathologic, and molecular data. METHODS: The cases included 13 FNAs for 9 low-grade (LG) IDCs and 4 high-grade (HG) IDCs with corresponding histopathology and available molecular, imaging, and clinical data. Smears and liquid-based preparations available for 12 FNAs were semiquantitatively scored for key cytomorphologic findings and correlated with the corresponding resection. RESULTS: LG IDC FNAs showed a cellular, biphasic population of large, atypical ductal cells with mildly pleomorphic nuclei in a clean background and a minor population of small, uniform myoepithelial cells. In contrast, all HG IDC FNAs showed predominantly ductal cells with marked nuclear pleomorphism, coarse chromatin, and necrosis. With the Milan system, most LG and HG IDC FNAs were classified as either salivary gland neoplasms of uncertain malignant potential (54%) or malignant (31%). Immunohistochemistry showed ductal epithelial reactivity with mammaglobin, androgen receptor, and S100, whereas myoepithelial cells were positive for p63 and/ or calponin. Among cases with next-generation sequencing, 4 LG IDCs showed NCOA4-RET gene fusions, whereas an HG IDC showed HRAS and PIK3CA mutations. CONCLUSIONS: The cytomorphology of IDC overlaps with other benign and malignant salivary gland neoplasms. Immunohistochemistry limits the differential diagnosis, but definitive classification requires molecular analysis. A diagnosis of IDC has potential implications for patient management. Cancer Cytopathol 2021;129: 928-946.

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Low-grade intraductal carcinoma of salivary glands: A systematic review of this rare entity

Cited by 22 publications

References 31 publications

MUC4 is a valuable marker for distinguishing secretory carcinoma of the salivary glands from its mimics

MUC4 is a valuable marker for distinguishing secretory carcinoma of the salivary glands from its mimics

Intraductal Carcinoma of the Parotid Gland Presenting as Parapharyngeal Mass

Cytomorphologic features of intraductal salivary gland carcinoma: A multi‐institutional study of 13 FNA cases with histologic, molecular, and clinical correlations

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