Low-Grade Inflammation and Estimates of Insulin Resistance during the Menstrual Cycle in Lean and Overweight Women

Blum, C; Müller, Beat; Huber, Peter; Kraenzlin, Marius; Schindler, Christian; Geyter, Christian De; Keller, Ulrich; Puder, Jardena J.

doi:10.1210/jc.2005-0231

Cited by 91 publications

(87 citation statements)

References 37 publications

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“…In the present study, we could not confirm cycle-dependent CRP variations in a clearly larger patient group and we did not find any correlation with E2. The differences between the results of Blum et al (30) and the present data can most likely be explained by the nearly four times larger sample size and the slightly shorter (and thus more sensitive) intervals between samplings (2 days maximum) in our study. In another study on CRP levels in the menstrual cycle with 18 patients (29), a CRP increase of 44% at midcycle and 31% in the luteal phase in comparison to follicular phase levels were found.…”

Section: Discussioncontrasting

confidence: 99%

“…Concerning the inflammatory mediator CRP, only a few trials with low number of subjects have been studying its concentration pattern during the normal spontaneous cycle. Blum et al (30) recently investigated eight young, normal-weight women with normal ovarian function and found that CRP concentrations changed significantly during the menstrual cycle. Concentrations were highest in the early follicular phase and inversely correlated to E2 concentrations.…”

Section: Discussionmentioning

confidence: 99%

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Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

Wunder¹,

Yared²,

Bersinger³

et al. 2006

eur j endocrinol

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Objective: Only a few studies have investigated variations of different markers for inflammatory processes during the physiological menstrual cycle. The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. The aim of the study was to investigate the inflammatory markers C-reactive protein (CRP) and leptin in the serum of healthy, normally ovulating women and to correlate these with each other and with the hormones of the gonadal axis. A cycle-dependence of the markers studied would imply an exact timing of the blood sampling for clinical needs. Design: Observational study investigating the two inflammatory markers CRP and leptin in relation to the hormonal pattern of the gonadal axis during the normal cycle. Methods: Ovulatory cycles of 36 healthy, young, normo-androgenic women, having a normal body mass index were evaluated. Serum concentrations of leptin and CRP, as well as of follicle-stimulating hormone, luteinising hormone, 17b-oestradiol, progesterone, prolactin (PRL) and free testosterone were measured every 1-2 days during one full cycle. Results: Serum levels of leptin and CRP behaved differently during ovulatory cycles, with higher concentrations for leptin only during certain phases. Significant correlations were found in the follicular phase between leptin and PRL and leptin and free testosterone. Conclusions: Leptin levels change during the menstrual cycle. Leptin levels are more stable on cycle days 1-5 than later in the cycle. For precise cycle-independent measurements, these fluctuations have to be taken into account. There is no similar cyclic pattern for CRP.European Journal of Endocrinology 155 137-142

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

Wunder¹,

Yared²,

Bersinger³

et al. 2006

eur j endocrinol

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“…26 Plasma was separated by centrifugation for 20 min at 2500 r.p.m. and 41C for the measurement of all inflammatory markers, cell adhesion molecules glucose and insulin, as well as TG, total cholesterol (total-C), low-density lipoproteins (LDL-C) and high-density lipoproteins (HDL-C) assessed by standard colorimetric reflectance spectrophotometry at the Fairview Diagnostics Laboratories, FairviewUniversity Medical Center (Minneapolis, MN, USA), a Center for Disease Control and Prevention certified laboratory.…”

Section: Blood Chemistry Measuresmentioning

confidence: 99%

Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women

et al. 2007

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Background: Overweight individuals commonly demonstrate elevated levels of inflammatory and cell adhesion molecules. Elevated levels of inflammation and adhesion have been implicated in the pathogenesis of cardiovascular disease. Aerobic exercise has been shown to be effective in altering specific biomarkers of inflammation and cell adhesion; however, little is known regarding the effects of resistance training (RT) on these biomarkers. This study examined the effects of 1 year of moderate-intensity RT on biomarkers of inflammation and adhesion in healthy, overweight women. Methods and Results: Participants included 28 (12 control, 16 RT) overweight (body mass indexX25 kg/m 2 ) women, aged 25-44 years, studied before and after 1 year of RT. C-reactive protein (CRP), interleukin-6 (IL-6), adiponectin, intracellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin were measured by standard enzyme-linked immunosorbent assays. Body composition, blood pressure, fasting blood lipids, glucose and insulin also were assessed. There were no significant changes in blood pressure, fasting blood lipids, glucose or insulin levels in either group after 1 year. There was also no change in body mass or fat mass in either group; however, there was a significant increase in lean body mass (Po0.05) in the RT group. Both CRP (Po0.01) and adiponectin (Po0.01) demonstrated significant improvements in the RT group, with no change in IL-6. Conversely, there were no associated changes in the biomarkers of cell adhesion in either group. Conclusions: This study demonstrates that moderate-intensity RT significantly results in modest improvements of inflammatory markers without affecting cell adhesion molecules in overweight women.

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“…In women of reproductive age, detection of basal CRP levels in diff erent phases of the menstrual cycle has been evaluated previously [14][15][16][17][18][19][20][21][22][23]. Nevertheless, the data about menstrual cycle variability of CRP is confl icting.…”

Section: Introductionmentioning

confidence: 99%

CRP at early follicular phase of menstrual cycle can cause misinterpretation for cardiovascular risk assessment

Gürsoy

Çağlar

Kiseli

et al. 2015

IMAS

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Abstract:Objective: C-reactive protein (CRP) is a well-known marker of infl ammation and infection in clinical practice. This study is designed to evaluate CRP levels in diff erent phases of menstrual cycle, which might end up with misleading conclusions especially when used for cardiovascular risk assessment. Methods: Twenty-seven women were eligible for the cross-sectional study. Venous blood samples from each participant were collected twice during the menstrual cycle. The fi rst sampling was held at 2nd to 5th days of the menstrual cycle for FSH, estradiol, CRP, and sedimentation, and the second was done at 21st to 24th days of the menstrual cycle for measurement of progesterone, CRP, and sedimentation values. Results: CRP values were signifi cantly higher in the early follicular phase compared to luteal phase (1.8 mg/L [0.3-7.67] vs. 0.7 mg/L [0.1-8.3], p < 0.001, respectively). In both phases of the menstrual cycle, sedimentation rate was similar (12.1 ± 6.7 vs. 12.3 ± 7.7; p = 0.717, respectively). Conclusions: CRP levels in early follicular phase of the menstrual cycle (menstruation) are signifi cantly higher than CRP levels in luteal phase of the same cycle. In reproductive age women, detection of CRP for cardiovascular risk assessment during menstruation might not be appropriate.

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Low-Grade Inflammation and Estimates of Insulin Resistance during the Menstrual Cycle in Lean and Overweight Women

Abstract: We demonstrate that serum concentrations of hs-CRP and SHBG significantly change during the menstrual cycle. We reveal a close link between sex steroids, subclinical inflammation, insulin resistance, and body fat distribution in regularly menstruating women.

Cited by 91 publications

References 37 publications

Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women

CRP at early follicular phase of menstrual cycle can cause misinterpretation for cardiovascular risk assessment

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