Low Grade Inflammation and ECG Left Ventricular Hypertrophy in Urban African Males: The SABPA Study

Walt, Carel van der; Malan, Leoné; Uys, Aletta Sophia; Malan, Nicolaas T.

doi:10.1016/j.hlc.2013.03.075

Cited by 17 publications

(7 citation statements)

References 42 publications

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“…In line with this evidence, we previously indicated that higher reactive oxygen species (ROS) in African men is associated with increased blood pressure (BP; Kruger et al, 2012), while attenuated total glutathione (tGSH) and upregulated glutathione reductase activity were associated with increased carotid intima media thickness (CIMT) in hypertensive African men (Schutte et al, 2009) and Caucasian men (van Zyl, Huisman, & Mels, 2016), respectively. We also observed a significant higher inflammatory status in African men compared to Caucasian men in this study cohort (Van der Walt, Malan, Uys, & Malan, 2013). These results clearly indicate ethnic differences between African and Caucasian men with regard to oxidative stress-related and inflammatory markers as well as associated BP elevations and vascular alterations.…”

supporting

confidence: 75%

Defensive coping and essential amino acid markers as possible predictors for structural vascular disease in an African and Caucasian male cohort: The SABPA study

et al. 2017

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Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative stress, changes in essential amino acids, and altered coping strategies are correlated with subclinical vascular changes in African (n = 82) and Caucasian (n = 100) men from the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study. The Coping Strategy Indicator questionnaire identified DefS participants. Ambulatory blood pressure (BP) was monitored for 24 h, whereas carotid intima media thickness (CIMT) and cross-sectional wall area (CSWA) were determined ultrasonically. Essential amino acids were analyzed with a liquid chromatography tandem mass spectrometry method. Oxidative-inflammatory markers were measured by spectrophotometry. African men had poorer health than Caucasian men, including higher alcohol abuse, elevated BP, abdominal obesity, physical inactivity, and elevated inflammation. Phe (p < .001) and Phe/Tyr ratio (p = .006) as well as CIMT (p = .032) were higher in African men. DefS African men had higher levels of Phe (p = .002) and Phe/Tyr (p = .009) compared to DefS Caucasian men; these differences were not observed in non-DefS men. Systolic BP and inflammation (C-reactive protein) were positively associated with left (L-) CSWA, while Phe/Tyr was negatively associated with L-CSWA in DefS African men. African males presented with elevated Phe and Phe/Tyr ratio, catecholamine precursors, worsening during DefS-possibly driven by inflammation and BP contributing to structural vascular abnormalities.

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confidence: 75%

Defensive coping and essential amino acid markers as possible predictors for structural vascular disease in an African and Caucasian male cohort: The SABPA study

et al. 2017

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“…In this regard, elevated serum estradiol levels reduce nocturnal erections and can contribute to ED, independent of testosterone levels. 35 – 38 Sixth, inflammation is known to be common among HD patients; 24 – 26 OH has been shown to aggravate systemic inflammation in this population. 45 Systemic inflammation may adversely affect sexual function by interfering with sex hormones.…”

Section: Discussionmentioning

confidence: 99%

The relationship between hydration status, male sexual dysfunction and depression in hemodialysis patients

Hassan¹,

Elimeleh²,

Shehadeh³

et al. 2018

TCRM

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BackgroundDisturbances in sexual function are common among dialysis patients. Normal erections require a complex balance of physiological, psychological, emotional, hormonal, neurological and vascular factors. This study examined a possible association of overhydration (OH) with male sexual dysfunction and depression in hemodialysis (HD) patients.Patients and methodsThis cross-sectional study assessed hydration status by whole-body bioimpedance spectroscopy in patients on maintenance HD for more than 12 months. Patients were categorized according to OH to extracellular water (ECW) ratio: OH/ECW ratio >0.15 and OH/ECW ratio ≤0.15. Sexual function was assessed using the International Index of Erectile Function (IIEF) score. Psychological status was evaluated using the Beck Depression Inventory (BDI) score. Serum sex hormones were determined.ResultsOf 39 stable participants on HD, 53.8% were overhydrated (OH/ECW ratio >0.15) and 46.2% not overhydrated (OH/ECW ratio ≤0.15). Of participants with OH/ECW ratio >0.15, 85.7% had mild to severe ED, and 71.4% had abnormal BDI scores, ranging from mild mood disturbance to severe depression. Compared to patients with OH/ECW ratio ≤0.15, BDI scores, serum estradiol and plasma hsCRP were higher (18.48±8.34 vs 10.61±5.46, p<0.001; 140.10±44.51 vs 126.10±32.26, p=0.034; and, 17.70±12.14 vs 9.76±8.79, p=0.013; respectively) in those with OH/ECW ratio >0.15, while their IIEF score, serum total testosterone and dehydroepiandrosterone (DHEA) were lower (12.81±7.31 vs 41.44±23.79, p<0.001; 8.97±5.43 vs 14.10±8.30, p=0.013; and 85.31±55.14 vs 133.3±95.48, p=0.029; respectively). The OH/ECW ratio correlated inversely with the IIEF score (r=−0.69, p<0.001) and positively with BDI scores (r=0.64, p<0.001). IIEF scores were inversely correlated with BDI scores (r=−0.54, p<0.001).ConclusionOH in HD patients was found to be associated with a higher prevalence of sexual dysfunction and depression, lower serum levels of total testosterone and DHEA, and higher levels of serum estradiol.

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“…Hypoalbuminemia, hypertension, and chronic inflammation are considered promoting factors for the development of atherosclerosis. 26 , 27 …”

Section: Discussionmentioning

confidence: 99%

The impact of oxidized serum albumin on the oncotic pressure and hydration status of peritoneal dialysis patients

Hassan

Kristal

Hassan

et al. 2016

TCRM

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ObjectiveHypoalbuminemia, fluid overload (FO), and oxidative stress (OS) may be related to cardiovascular morbidity and mortality in peritoneal dialysis (PD) patients. OS produces molecular modifications of serum albumin that interfere with its quantification by the commonly used bromocresol green assay. This study evaluated the impact of oxidized serum albumin (OSA) on oncotic pressure (OP) and hydration status.Patients and methodsTwenty-four stable hypoalbuminemic PD patients were enrolled in the study. After performing physical examination, assessment of the hydration status using a whole-body bioimpedance spectroscopy technique was performed, and blood samples were drawn for determination of OP, serum albumin levels, and OSA.ResultsExtracellular to total body water (E/TBW) ratio was higher in patients with FO ≥1.5 L with or without edema than in patients with FO <1.5 L (P≤0.043). E/TBW ratio was higher in patients with FO ≥1.5 L and edema compared to those with FO ≥1.5 L but without edema (P=0.004). OP was significantly higher in patients with FO ≥1.5 L and without edema compared to those with FO ≥1.5 L and with edema (P<0.001). Albumin-detection index (ADI) in patients with FO ≥1.5 L and without edema was similar to ADI in patients with FO <1.5 L (P=0.520). ADI was significantly lower in patients with FO ≥1.5 L and without edema compared to those with FO ≥1.5 L and edema (P=0.034). E/TBW ratio correlated positively with the ADI (r=0.60, P=0.001) and inversely with the OP (r=−0.54, P=0.002).ConclusionOverhydration may be clinically undetectable in PD patients. Assessing the hydration status and measuring the total serum albumin levels, including the oxidized fraction, should be considered in evaluating hydration status in PD patients.

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Low Grade Inflammation and ECG Left Ventricular Hypertrophy in Urban African Males: The SABPA Study

Cited by 17 publications

References 42 publications

Defensive coping and essential amino acid markers as possible predictors for structural vascular disease in an African and Caucasian male cohort: The SABPA study

Defensive coping and essential amino acid markers as possible predictors for structural vascular disease in an African and Caucasian male cohort: The SABPA study

The relationship between hydration status, male sexual dysfunction and depression in hemodialysis patients

The impact of oxidized serum albumin on the oncotic pressure and hydration status of peritoneal dialysis patients

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