Low-Grade Fibromyxoid Sarcoma of the Hand: A Case Report

Rubin, Guy; Rinott, Micha; Wolovelsky, Alejandro; Elmalach, Irit; Rozen, Nimrod

doi:10.1007/s11552-010-9277-5

Cited by 9 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Superficial angiomyxomas have a lobular appearance and are purely myxoid, lacking the collagenous component of the stroma of acral fibromyxoma. Superficial examples of LGFMS very rarely arise in the digits, have a mixed fascicular and whirling growth pattern and often more abrupt transition from myxoid to fibrous areas. LGFMS is also consistently positive for MUC4, which is both very sensitive and specific for this diagnosis.…”

Section: Acral Fibromyxomamentioning

confidence: 99%

Myxoid cutaneous tumors: a review

Zou

Billings

2016

J Cutan Pathol

View full text Add to dashboard Cite

Unified by the common finding of myxoid background, the group of myxoid cutaneous tumors comprises many entities with different lineages, immunohistochemical profiles, underlying genetic abnormalities and biologic behaviors. These tumors may have significant histopathologic overlap causing diagnostic difficulty. Careful attention to subtle histopathologic features is key to accurate diagnosis. Immunohistochemical stains and molecular tests are valuable in selected cases. This review discusses selected myxoid tumors and myxoid variants of cutaneous tumors and focuses on key pathologic features and an effective strategy for the use of ancillary tests.

show abstract

Section: Acral Fibromyxomamentioning

confidence: 99%

Myxoid cutaneous tumors: a review

Zou

Billings

2016

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

“…4 Wide excision with negative margins has been shown to help to avoid local recurrence. 24,25 Negative margins are the most critical component in treating LGFMS and should not be sacrificed to preserve function or for radiation therapy. 29 In our review, one case with a positive margin after excision reported a recurrence after 5 months, supporting this notion.…”

Section: Discussionmentioning

confidence: 99%

Low-Grade Fibromyxoid Sarcoma of the Distal Upper Extremity: A Systematic Review

Kim

Policherla²,

Linhares

et al. 2023

Hand (New York, N,Y.)

View full text Add to dashboard Cite

Background: Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue tumor that usually occurs in the proximal extremities and trunk. The purpose of this systematic review was to assess patient demographics, treatment approach, and outcomes for patients with LGFMS of the distal upper extremity. Methods: We performed a literature review of case reports and patient reports of LGFMS using Medical Literature Analysis and Retrieval System Online (MEDLINE) and PubMed. Inclusion criteria included case reports and case series of patients with LGFMS of the distal upper extremity. Animal studies, comments, and non-English publications were excluded. Data on available patient demographics, treatment regimen, recurrence, and metastasis were collected. Results: A total of 365 publications were reviewed. After applying the inclusion and exclusion criteria, 19 articles were included. There were 24 unique patients with LGFMS of the distal upper extremity. The median age was 32 years, and most patients were treated with a surgical excision. Of the 15 reported outcomes, 4 patients had local recurrences, and no patient had metastases or died due to the tumor. Conclusions: Although LGFMS of the distal upper extremity is less common, it is critical for surgeons to consider it as a differential. The current approach is a wide excision with negative margins, and chemotherapy or radiotherapy may not be necessary. We found decreased proportions of local recurrence and metastases in the distal upper extremity compared with other anatomical regions. We recommend that surgeons follow up with their patients indefinitely given the slow mitotic rate of LGFMS.

show abstract

“…Involvement of acral sites is not highly emphasized in the literature. After encountering this case, we reviewed the literature and found 24 cases (mostly embedded in case series) of LGFMS involving distal extremities and acral sites (Table ) …”

Section: Discussionmentioning

confidence: 99%

Low‐grade fibromyxoid sarcoma of acral sites: Case report and literature review

Saab‐Chalhoub

Al‐Rohil

2019

J Cutan Pathol

View full text Add to dashboard Cite

Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft tissue sarcoma that usually presents as a deep-seated tumor in young adults; however, they can occur on superficial sites, mostly documented in pediatric age groups.LGFMS presenting on acral sites is not highly emphasized in the general pathology or dermatopathology literature. The case presented is that of a 30-year-old man with a foot mass that was removed 15 years earlier and subsequently recurred as two masses, the first occurring between the third and fourth toes/metatarsal region and the second over the lateral tarsal region. An excisional biopsy showed a relatively circumscribed, bland spindle cell proliferation with hypocellular and hypercellular zones. The cells showed minimal pleomorphism and lacked mitotic activity. Immunohistochemical analysis showed immunoreactivity for MUC4 and break-apart fluorescence in situ hybridization was positive for FUS rearrangement, confirming the diagnosis of LGFMS. There are multiple spindle cell tumors that occur on acral sites which usually generates a list of differential diagnoses; however, LGFMS is not usually discussed in that anatomic location. Awareness of the occurrence of LGFMS on acral sites is important to avoid misdiagnosis of this deceptively benign-appearing tumor.

show abstract

Low-Grade Fibromyxoid Sarcoma of the Hand: A Case Report

Abstract: We report a case of low-grade fibromyxoid sarcoma with giant collagen rosettes in the hand of a 21-year-old female. This is a clinically and radiological benign appearing tumor that has a high rate of recurrence and metastasis.

Cited by 9 publications

References 33 publications

Myxoid cutaneous tumors: a review

Myxoid cutaneous tumors: a review

Low-Grade Fibromyxoid Sarcoma of the Distal Upper Extremity: A Systematic Review

Low‐grade fibromyxoid sarcoma of acral sites: Case report and literature review

Contact Info

Product

Resources

About