Low-grade fibromyxoid sarcoma of the sigmoid colon

Mendoza, Alejandro; O’Leary, Michael P.; Peng, Shi‐Kaung; Petrie, Beverley A.; Li, Andrew; French, Samuel W.

doi:10.1016/j.yexmp.2015.02.007

Cited by 13 publications

(11 citation statements)

References 17 publications

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“…For instance, we examined several markers such as desmin, S-100, CD34, and EMA, but the results were negative (data not shown). The findings are consistent with the published literatures [2, 10, 15]. Doyle and colleagues identified MUC4 as a highly sensitive and specific marker for LGFMS through gene expression profiling.…”

Section: Discussionsupporting

confidence: 91%

“…LGFMS occurring in the perineal space is extremely rare and only a few cases have been reported [10–17]. Park et al published the first LGFMS in the colon of a 43-year-old man whose tumor was surgically removed along with the creation of right hemicolectomy combined with nephrectomy.…”

Section: Discussionmentioning

confidence: 99%

“…In another case, Mendoza and colleagues recently reported a 48-year-old female with LGFMS that arose from the sigmoid colon without metastatic disease. Despite the patient later developed a bowel obstruction that required another surgery, she ultimately recovered and was discharged to home; however, the follow-up information is not available [10]. Although LGFMS has a relatively good prognosis, the rate of local recurrence and late metastasis are high [15].…”

Section: Discussionmentioning

confidence: 99%

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Low-grade fibromyxoid sarcoma of the external anal sphincter: a case report

et al. 2017

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BackgroundLow-grade fibromyxoid sarcoma (LGFMS) is a rare soft tissue tumor that has a tendency to grow in the deep soft tissue of the trunk and extremities. Despite its benign appearance, the tumor has a high recurrence rate and metastatic potential. LGFMS in the perineal space is rare, and only a few cases have been reported. We present the first case of LGFMS to be located at the external anal sphincter.Case presentationA 27-year-old male patient admitted to our Surgical Department with perianal pain and swollen for a year. The digital rectal examination revealed a perianal mass. Oral metronidazole and analgesia were prescribed on suspicion of perianal abscess failed to alleviate the symptom; hence, the patient was scheduled for surgery. Intraoperative diagnosis revealed an encapsulated tumor in the external anal sphincter that extended from the perianal region orally to the pararectal space. The results of immunohistochemistry (MUC4 staining) and FUS gene rearrangement by fluorescence in situ hybridization confirmed the diagnosis of LGFMS.ConclusionsThis case is unique in terms of the location of the rare soft tissue tumor. Although LGFMS is considered low grade, its unpredictable behavior necessitates a long-term follow-up.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Low-grade fibromyxoid sarcoma of the external anal sphincter: a case report

et al. 2017

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“…Typically presenting as a deep‐seated (below fascia) soft tissue painless mass mostly affecting the extremities and trunk . LGFMS has been reported in variable anatomic locations including the head and neck, gastrointestinal tract, heart, kidney, and brain . Involvement of acral sites is not highly emphasized in the literature.…”

Section: Discussionmentioning

confidence: 99%

Low‐grade fibromyxoid sarcoma of acral sites: Case report and literature review

Saab‐Chalhoub

Al‐Rohil

2019

J Cutan Pathol

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Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft tissue sarcoma that usually presents as a deep-seated tumor in young adults; however, they can occur on superficial sites, mostly documented in pediatric age groups.LGFMS presenting on acral sites is not highly emphasized in the general pathology or dermatopathology literature. The case presented is that of a 30-year-old man with a foot mass that was removed 15 years earlier and subsequently recurred as two masses, the first occurring between the third and fourth toes/metatarsal region and the second over the lateral tarsal region. An excisional biopsy showed a relatively circumscribed, bland spindle cell proliferation with hypocellular and hypercellular zones. The cells showed minimal pleomorphism and lacked mitotic activity. Immunohistochemical analysis showed immunoreactivity for MUC4 and break-apart fluorescence in situ hybridization was positive for FUS rearrangement, confirming the diagnosis of LGFMS. There are multiple spindle cell tumors that occur on acral sites which usually generates a list of differential diagnoses; however, LGFMS is not usually discussed in that anatomic location. Awareness of the occurrence of LGFMS on acral sites is important to avoid misdiagnosis of this deceptively benign-appearing tumor.

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“…low-grade fibromyxoid sarcoma (LGFMS) or Evans tumor has been described in 1987 by Evans as an indolent soft tissue tumor and potentially metastasizing tumor. 1 This tumor has distinctive histopathologic findings with bland morphology and an aggressive behaviour. 2 The most common location of this soft tissue tumor is lower extremities of young patients, especially thigh.…”

Section: Introductionmentioning

confidence: 99%

Huge mesenteric low-grade fibromyxoid sarcoma: A case report and review of the literature

et al. 2018

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Low-grade fibromyxoid sarcoma is a rare soft tissue tumor which has been mostly reported in lower extremities; however, it can also occur in other parts of the body such as head and neck and abdominal wall, but its occurrence in the abdominal cavity and mesentery of bowel is an extremely rare event and has very rarely been reported. Herein, we report our experience with a 24-year-old lady with a huge mesenteric mass, turned out to be low-grade fibromyxoid sarcoma. This case is the largest one reported in the English literature. We will also discuss about the previously reported cases of low-grade fibromyxoid sarcoma in the English literature.

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Low-grade fibromyxoid sarcoma of the sigmoid colon

Cited by 13 publications

References 17 publications

Low-grade fibromyxoid sarcoma of the external anal sphincter: a case report

Low-grade fibromyxoid sarcoma of the external anal sphincter: a case report

Low‐grade fibromyxoid sarcoma of acral sites: Case report and literature review

Huge mesenteric low-grade fibromyxoid sarcoma: A case report and review of the literature

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