Low-grade dietary-related inflammation and survival after colorectal cancer surgery

Gałaś, Aleksander; Kulig, Jan

doi:10.1007/s00432-014-1711-6

Cited by 17 publications

(26 citation statements)

References 35 publications

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“…This trend toward a lack of association with longer survival time could confirm our results of no association between DII score (on average assessed 6 years after diagnosis) and mortality after a median follow‐up time of 7 years in the overall sample. However, the previous study only observed associations in patients without distant metastases who had undergone surgery and chemotherapy which is in contrast to our findings of a stronger association between the DII and risk of dying in those CRC survivors with metastases. In addition, the former study assessed dietary behavior prior to CRC surgery after hospital admission which is likely to occur relatively soon after diagnosis and which is different to our diet assessment at a median of 6 years after CRC diagnosis.…”

Section: Discussioncontrasting

confidence: 99%

“…In contrast to this growing number of studies that investigated the association between dietary inflammatory potential and the risk of new‐onset (incident) CRC, the association between post‐diagnosis DII score and mortality in long‐term CRC survivors is a relatively novel area of research. To our knowledge, only one previous study ( n = 689) examined the association between low‐grade diet‐related inflammation (measured by the DII) and survival after CRC . The authors observed a statistically significant association between the DII and an increased risk of mortality only at time points 1 and 3 years after CRC surgery, not at 5 years after surgery, and not in overall survival.…”

Section: Discussionmentioning

confidence: 96%

“…Previous studies examined the association between the DII and the incidence of different cancers, including CRC, with most reporting an increased cancer incidence associated with a higher DII (corresponding to a more pro‐inflammatory diet). However, to the best of our knowledge, studies on the association of the DII with mortality in CRC patients and survivors are scarce, with only one previously published study ( n = 689) that examined the relationship between diet‐related inflammation and survival after CRC surgery …”

Section: Introductionmentioning

confidence: 99%

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Association between the dietary inflammatory index and all‐cause mortality in colorectal cancer long‐term survivors

Ratjen

Shivappa

Schafmayer

et al. 2018

Intl Journal of Cancer

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Pro-inflammatory dietary factors have been shown to be associated with the incidence of a range of cancers. However, there are many fewer studies on the association between the inflammatory potential of diet and survival after cancer diagnosis. We examined the association between post-diagnosis dietary inflammatory index (DII ® ) scores and all-cause mortality in long-term survivors of colorectal cancer (CRC). DII scores were calculated from dietary data of 1,404 CRC survivors collected at a median of 6 years after CRC diagnosis. Using multivariable-adjusted Cox proportional hazards regression models, hazard ratios (HR) and 95% confidence intervals (CI) were estimated for the association of DII scores, modeled continuous and in quartiles, with all-cause mortality. After a median follow-up time of 7 years (after dietary assessment), 204 study participants had died. Overall, in the fully adjusted model there was a suggestion of a positive association between DII score and all-cause mortality (HR DIIquartile4vs1 : 1.36; 95% CI: 0.88-2.09 and HR DIIcontinuous : 1.08; 95% CI: 0.97-1.20). However, in subgroup analyses, we found significant differences in individuals with metastatic disease (HR DIIcontinuous : 1.34; 95% CI: 1.07-1.67) and the absence of stoma (HR DIIcontinuous : 1.15; 95% CI: 1.02-1.29). Overall, the post-diagnosis DII was not statistically significantly associated with all-cause mortality in CRC long-term survivors; however, there was suggestive evidence of an association in select subgroups.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Association between the dietary inflammatory index and all‐cause mortality in colorectal cancer long‐term survivors

Ratjen

Shivappa

Schafmayer

et al. 2018

Intl Journal of Cancer

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“…In practice, the DII score is usually computed from dietary intake assessed using a validated FFQ or from historical dietary records. Apart from the significant association of the DII score with CRC risk, the DII score could also be used to predict the prolonged hospitalization and survival among CRC patients treated surgically [ 21 , 22 ]. However, no statistically significant associations were found between a pro-inflammatory diet and the risk of colorectal adenoma recurrence [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk

et al. 2017

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ObjectivesThe inflammatory potential of diet has been inconsistently linked to colorectal cancer (CRC) risk. This meta-analysis aimed to evaluate the association of the inflammatory potential of diet, as estimated by the dietary inflammatory index (DII) score, with CRC risk.Materials and MethodsThe PubMed and Embase databases were searched for relevant studies from inception to February 2017. All cohort and case–control studies investigating the association of the DII score with CRC risk were selected.ResultsFour prospective cohorts and four case–control studies, which enrolled a total of 880,380 participants, were included. The pooled adjusted risk ratio (RR) of CRC for the highest DII score versus the lowest category was 1.43 (95% confidence interval [CI]: 1.26–1.62). When stratified by study design, the RRs for the case–control and cohort studies were 1.27 (95% CI: 1.16–1.38) and 1.81 (95% CI: 1.48–2.22), respectively. Subgroup analysis showed that individuals with the highest category of DII score were independently associated with CRC risk in men (RR=1.51; 95% CI: 1.29–1.76), women (RR=1.25; 95% CI: 1.10–1.41), colon cancer (RR=1.39; 95% CI: 1.19–1.62), and rectal cancer (RR=1.32; 95% CI: 1.01–1.74). However, the pooled RR was 1.07 (95% CI: 0.87–1.31) for rectal cancer among the prospective cohort studies.ConclusionsAs estimated by a high DII score, pro-inflammatory diet is independently associated with increased CRC risk. This finding confirms that low inflammatory potential diet may reduce CRC risk. However, the gender- and cancer site-specific associations of the DII score with CRC risk need to be further investigated.

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“…For the updated version, several studies have found associations between DII score and CRP, in adults and seniors [26], and IL-6, tumour necrosis factor-alpha (TNF-α) and another score of combined inflammatory biomarker in postmenopausal women [27]. The DII score has been used in several studies to predict mortality [28,29], survival [30], and diseases, especially cancer [30,31], but also obesity [32], cardiovascular disease [33] and metabolic syndrome [32,34].…”

Section: Introductionmentioning

confidence: 99%

Dietary inflammatory index and inflammatory biomarkers in adolescents from LabMed physical activity study

et al. 2017

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Background/objectives The dietary inflammatory index (DII) is a tool to measure the diet's inflammatory potential and has been used with adults to predict low-grade inflammation. The present study aims to assess whether this dietary score predicts low-grade inflammation in adolescents.Subjects/methods The sample comprises 329 adolescents (55.9% girls), aged 12-18 years, from LabMed Physical Activity Study. DII score was calculated based on a food-frequency questionnaire and categorized into tertiles. We collected blood samples to determine the follow inflammatory biomarkers: C-reactive protein (CRP), interleukin-6 (IL-6), complement component 3 (C3), and 4 (C4). In addition we calculated an overall inflammatory biomarker score. Odds ratios (OR) and 95% confidence intervals (95%CI) were computed from binary logistic regression models.Results DII score, comparing first with third tertile, was positively associated with IL-6 in crude model (OR = 1.88, 95% CI:1.09-3.24, p trend = 0.011) and in fully adjusted (for biological and lifestyle variables) (OR = 3.38, 95%CI:1.24-9.20, p trend = 0.023). Also, DII score was positively associated with C4, when fully adjusted (OR = 3.12, 95%CI:1.21-8.10, p trend = 0.016). DII score was negatively associated with C3 in crude model, comparing first with second but not with third tertile, and no significant associations in fully adjusted model were observed, although a trend was found (OR = 1.71, 95% CI:0.63-4.66, p trend = 0.044). No significant associations were observed between DII score and CRP. However, DII score was positively associated with the overall inflammatory biomarker score, when fully adjusted (OR = 5.61, 95% CI:2.00-15.78, p trend = 0.002).Conclusions DII score can be useful to assess the diet's inflammatory potential and its association with low-grade inflammation in adolescents.

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Low-grade dietary-related inflammation and survival after colorectal cancer surgery

Cited by 17 publications

References 35 publications

Association between the dietary inflammatory index and all‐cause mortality in colorectal cancer long‐term survivors

Association between the dietary inflammatory index and all‐cause mortality in colorectal cancer long‐term survivors

Meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk

Dietary inflammatory index and inflammatory biomarkers in adolescents from LabMed physical activity study

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