Low-Grade B-Cell Lymphoma Presenting as a Uvular Mass

Walker, Ryan; Heffelfinger, Ryan

doi:10.1177/014556131209101218

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Lymphoma involving the uvula is a rare malignant condition not well-described, and only a few cases have been reported in the literature. All previously published and the present cases of uvular lymphomas are presented in Table 1 and provides an overview of demographics, clinical presentation, subtype, possible dissemination, stage, imaging, treatment, and outcome (6)(7)(8)(9)(10)(11)(12)(13). Two of the present cases (case 3 and 4) were classified as local extensions from a tonsillar lymphoma (Table 1).…”

Section: Discussionmentioning

confidence: 96%

Lymphoma of the Uvula: Clinical, Morphological, Histopathological, and Genetic Characterization. A Nationwide Danish Study From 1980 to 2019

et al. 2021

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Background: In the head and neck region the uvula is a rare site for extranodal lymphomas to develop. In this national study, we present six cases and provide an overview of the current literature, characterizing the clinical and histopathological features of lymphomas involving this location.Materials and Methods: Clinical information was obtained retrospectively from patient records in a nationwide Danish study covering from 1980 through 2019. In order to validate the diagnoses, uvular tissue specimens were examined histologically and immunohistochemically and if relevant for subtyping, cytogenetic rearrangements were investigated.Results: We present six cases of lymphomas involving the uvula, of which four of the cases were diagnosed with a B-cell lymphoma (two diffuse large B-cell lymphomas, one extranodal marginal zone B-cell lymphoma and one Mantle cell lymphoma), while two were diagnosed with a T-cell lymphoma (one peripheral T-cell lymphoma and one natural killer/T-cell lymphoma). Presenting symptoms included swelling, pain and ulceration of the uvula. Treatment was comprised of radiotherapy and/or chemotherapy, with T-cell lymphomas showing a poorer outcome than B-cell lymphomas.Conclusion: Lymphoma of the uvula is rare, with few case reports being reported in the literature. The most frequent histological subtypes reported are extranodal marginal zone B-cell lymphoma and peripheral T-cell lymphoma. When encountering a swollen, painful and/or ulcerated uvula, the clinician should always consider malignancy as a possible cause. Lymphoma of the uvula is a possible diagnosis and if this is the case, there is a high risk of disseminated disease at the time of diagnosis.

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Section: Discussionmentioning

confidence: 96%

Lymphoma of the Uvula: Clinical, Morphological, Histopathological, and Genetic Characterization. A Nationwide Danish Study From 1980 to 2019

et al. 2021

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“…Metastatic spread of RCC was felt to be the most likely diagnosis, however the possibility of a new primary lesion of the uvula could not be excluded. Differential diagnosis included squamous cell carcinoma, lymphoma,7 8 benign polyp and oral squamous papilloma 9…”

Section: Differential Diagnosismentioning

confidence: 99%

Renal cell carcinoma uvula metastasis leading to airway compromise: an unusual site

Wallace

Abelardo

et al. 2022

BMJ Case Rep

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We present a case report of a gentleman presenting with a globular lesion arising from his uvula. Although elective admission was planned, he presented with airway compromise, and emergency excision was required. The patient had a background of metastatic clear cell renal carcinoma; histology confirmed the uvula lesion as a further secondary deposit. Renal cell carcinoma has a recognised metastatic propensity, but spread to the uvula is rare, with only two previously described cases in the literature. This case is notable for the unusual location of the metastasis, as well as the rapid progression of symptoms, which threatened the airway and necessitated urgent surgical intervention.

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“…The current case was presented with progressively worsening odynophagia and sore throat for a period of over six months with uvular enlargement. Walker presented a case of low grade B-cell lymphoma presenting as a uvular mass [6]. A follicular lymphoma of the uvula was described by Kusunoki [7].…”

Section: Case Presentationmentioning

confidence: 99%

Peripheral T-cell Lymphoma of the Uvula: A Rare Entity

Binesh

Ardakani

Shahcheraghi

2019

Multidiscip Cancer Investig

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Introduction: Extra-nodal exposition of T-cell non-hodgkin lymphoma (NHL) is extremely rare, and is frequently observed in patients with immune system dysfunction. Peripheral T-cell lymphoma does not express CD 56is rare. Malignant lymphoma of the uvula is exceedingly unusual. The current study reported a case of peripheral T-cell lymphoma of the uvula in an immunecompetent patient. Case presentation: The current study reported a case of peripheral T-cell lymphoma of the uvula in a 54-year-old male patient. The diagnosis was based on excisional biopsy and ancillary techniques. The patient was referred to the hemato-oncology ward for treatment. Conclusion: Considering the fact that the presentation of peripheral T-cell NHL in uvula is uncommon, a high index of suspicion is necessary to diagnose this grave disease. To the best of authors` knowledge, this case is the third case of T-cell lymphoma of the uvula in the English literature.

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Low-Grade B-Cell Lymphoma Presenting as a Uvular Mass

Cited by 4 publications

References 14 publications

Lymphoma of the Uvula: Clinical, Morphological, Histopathological, and Genetic Characterization. A Nationwide Danish Study From 1980 to 2019

Lymphoma of the Uvula: Clinical, Morphological, Histopathological, and Genetic Characterization. A Nationwide Danish Study From 1980 to 2019

Renal cell carcinoma uvula metastasis leading to airway compromise: an unusual site

Peripheral T-cell Lymphoma of the Uvula: A Rare Entity

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