Low glucose availability potentiates the effects of metformin on model T cell activation and exhaustion markers in vitro
Jernej Repas,
Lea Peternel,
Harald Sourij
et al.
Abstract:Modulation of immune cell metabolism is one of promising strategies to improve cancer immunotherapies. Metformin is an anti-diabetic drug with potential anti-cancer effects, ranging from normalization of blood glucose and insulin levels, direct anti-proliferative effects on cancer cells to emerging immunomodulatory effects on anti-tumor immunity. Metformin can reduce tumor hypoxia and PD-L1 expression, as well as normalize or improve T cell function and potentiate the effect of immune checkpoint inhibitors, ma… Show more
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