Low Gene Flow of Aedes aegypti between Dengue-Endemic and Dengue-Free Areas in Southeastern and Southern Brazil

Costa-Ribeiro, Magda Clara Vieira da; Lourenço‐de‐Oliveira, Ricardo; Failloux, Anna‐Bella

doi:10.4269/ajtmh.2007.77.303

Cited by 25 publications

(42 citation statements)

References 37 publications

(33 reference statements)

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“…Considering Ae. aegypti mosquitoes only fly 10–800 m in the course of their lifetimes (da Costa–Ribeiro et al 2007), passive migration, such as road transport along the Overseas highway, likely explains these patterns. The analysis of migration, along with observed patterns of genetic diversity, suggest that increased gene flow among Ae.…”

Section: Discussionmentioning

confidence: 99%

Phylogeography and Spatio-Temporal Genetic Variation of <I>Aedes aegypti</I> (Diptera: Culicidae) Populations in the Florida Keys

et al. 2013

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Aedes aegypti (L.) is the principal mosquito vector of dengue fever, the second-most deadly vector-borne disease in the world. In Ae. aegypti and other arthropod disease vectors, genetic markers can be used to inform us about processes relevant to disease spread, such as movement of the vectors across space and the temporal stability of vector populations. In late 2009, 27 locally acquired cases of dengue fever were reported in Key West, FL. The last dengue outbreak in the region occurred in 1934. In this study, we used 12 microsatellite loci to examine the genetic structure of 10 Ae. aegypti populations from throughout the Florida Keys and Miami to assess gene flow along the region’s main roadway, the Overseas Highway. We also assessed temporal genetic stability of populations in Key West to determine whether the recent outbreak could have been the result of a new introduction of mosquitoes. Though a small amount of geographic genetic structure was detected, our results showed high overall genetic similarity among Ae. aegypti populations sampled in southeastern Florida. No temporal genetic signal was detected in Key West populations collected before and after the outbreak. Consequently, there is potential for dengue transmission across southeastern Florida; renewed mosquito control and surveillance measures should be taken.

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Section: Discussionmentioning

confidence: 99%

Phylogeography and Spatio-Temporal Genetic Variation of <I>Aedes aegypti</I> (Diptera: Culicidae) Populations in the Florida Keys

et al. 2013

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“…aegypti have been reported to be genetically structured with relatively little gene flow among them as well as different levels of insecticide resistance. 56,57 Therefore, the fact that two localities in Northeast (Natal) and Southeast (Nova Iguaçu) Brazil separated by more than 1,200 miles (more than 1,900 km) share very similar haplotype frequencies in the AaNa V , suggests that this polymorphism is under strong balancing selection. We are currently researching the prevalence of different haplotypes in the IIS6 region of the AaNa V in other Brazilian localities and their relative contribution to PY resistance.…”

Section: Discussionmentioning

confidence: 99%

Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil

Martins¹,

Lins²,

Linss³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

113

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The nature of pyrethroid resistance in Aedes aegypti Brazilian populations was investigated. Quantification of enzymes related to metabolic resistance in two distinct populations, located in the Northeast and Southeast regions, revealed increases in Glutathione-S-transferase (GST) and Esterase levels. Additionally, polymorphism was found in the IIS6 region of Ae. aegypti voltage-gated sodium channel (AaNa(V)), the pyrethroid target site. Sequences were classified in two haplotype groups, A and B, according to the size of the intron in that region. Rockefeller, a susceptible control lineage, contains only B sequences. In field populations, some A sequences present a substitution in the 1011 site (Ile/Met). When resistant and susceptible individuals were compared, the frequency of both A (with the Met mutation) and B sequences were slightly increased in resistant specimens. The involvement of the AaNa(V) polymorphism in pyrethroid resistance and the metabolic mechanisms that lead to potential cross-resistance between organophosphate and pyrethroids are discussed.

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“…Já se verifi cou que no Brasil a variação genética do mosquito é independente da distância geográfi ca separando cidades, o que sustenta a hipótese de que os Ae. aegypti infectados não são passíveis de espalhar o vírus da dengue por longas distâncias, independentemente do período do ano (COSTA-RIBEIRO et al, 2007). Essa conclusão pode levar à assertiva de que neste país, se a questão da rápida dispersão do vírus da dengue não está relacionada à mobilidade do mosquito por rotas entre cidades e regiões, os mais prováveis propulsores de tal circulação são os fl uxos de seres humanos contaminados, o que evidencia a importância desse componente da dinâmica demográfi ca.…”

Section: A Importância Da Mobilidade Populacionalunclassified

Dengue e falta de infraestrutura urbana na Amazônia brasileira: o caso de Altamira (PA)

Johansen¹,

Carmo²

2012

Novos Cadernos NAEA

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Procurou-se compreender neste estudo quais foram os principais fatores que contribuíram para a defl agração das epidemias de dengue no município de Altamira (Pará) nos anos de 2009 e 2010. Para tanto, buscou-se realizar a análise da relação dialética estabelecida entre população e ambiente. A dinâmica ambiental foi verifi cada a partir das condições de saneamento básico do município. Já a dinâmica populacional foi aferida a partir da observação da morbidade e mortalidade por dengue. Concluiu-se que a dengue consiste em um fenômeno complexo pela sua multicausalidade, ou seja, por possuir imbricações diversas e complexas entre seus fatores causais. Verifi cou-se, ainda, que as condições do saneamento básico ou infraestrutura urbana, mostraram ser não o único fator, mas provavelmente um dos mais importantes a serem considerados enquanto capazes de propiciar o desencadeamento de uma realidade epidêmica de dengue.

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Low Gene Flow of Aedes aegypti between Dengue-Endemic and Dengue-Free Areas in Southeastern and Southern Brazil

Cited by 25 publications

References 37 publications

Phylogeography and Spatio-Temporal Genetic Variation of <I>Aedes aegypti</I> (Diptera: Culicidae) Populations in the Florida Keys

Phylogeography and Spatio-Temporal Genetic Variation of <I>Aedes aegypti</I> (Diptera: Culicidae) Populations in the Florida Keys

Voltage-Gated Sodium Channel Polymorphism and Metabolic Resistance in Pyrethroid-Resistant Aedes aegypti from Brazil

Dengue e falta de infraestrutura urbana na Amazônia brasileira: o caso de Altamira (PA)

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