Low-frequency transcranial magnetic stimulation for visual spatial neglect: A pilot study

Song, Weiqun; Du, Bin; Xu, Qian; Hu, Jie; Wang, Maobin; Luo, Yuejia

doi:10.2340/16501977-0302

Cited by 90 publications

(80 citation statements)

References 11 publications

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“…Our observation of a reduction in visuospatial neglect after cTBS over the unaffected PPC is in line with other noninvasive brain stimulation studies, which used singlepulse TMS and paired TMS as a 'virtual lesion' technique, 23,24 low-frequency ( 1 Hz) repetitive TMS, 17,24,25 cathodal transcranial direct current stimulation 26 or continuous TBS. 10,12 Koch et al 10 applied left PPC TBS in two sessions per day with an interval of 15 min every day for 2 weeks (10 days), which reduced hemispatial neglect for up to 2 weeks after treatment: behavioural inattention test scores improved by 16.3% at There were no significant differences between the treatment groups (post hoc tests: least significant difference or Student-Newman-Keuls).…”

Section: Discussionsupporting

confidence: 70%

“…17 Moreover, patients were excluded for any of the following reasons: recurrent stroke, obvious aphasia and communication obstacles, family history of seizures, ever use of tricyclic antidepressants or antipsychotic drugs, in vivo diamagnetic metal implants such as cardiac pacemakers and age <30 years or >80 years. Also, patients with visual field defects detected by the confrontation method were excluded.…”

Section: Inclusion/exclusion Criteriamentioning

confidence: 99%

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Long-term effects of continuous theta-burst stimulation in visuospatial neglect

Song

Zhang

et al. 2015

J Int Med Res

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Objective: To investigate whether the efficacy of continuous theta-burst stimulation (cTBS) for improving visuospatial neglect can be enhanced by providing more days of stimulation and more stimulation trains per day. Methods: In a prospective study, right-handed patients with right hemisphere stroke and visuospatial neglect were randomized to cTBS or sham cTBS treatment for 2 weeks and were followed up for 4 weeks. The cTBS group received active cTBS over the posterior parietal cortex of the unaffected hemisphere, combined with conventional rehabilitation therapy. Changes in scores for two paper-pencil tests for visuospatial neglect (star cancellation and line bisection) were evaluated. Results: In each group, 10 patients completed follow up. Compared with the sham group, star cancellation test scores in the cTBS group were improved by 37.03% at the end of treatment and by 47.21% after 4 weeks' follow up, and the line bisection score improved by 21.37% at the end of treatment and by 35.99% after 4 weeks' follow up. Conclusions: These results suggest that the efficacy of cTBS in visuospatial neglect can be enhanced and prolonged by increasing the days of stimulation and the number of stimulation trains per day over the left posterior parietal cortex.

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Section: Discussionsupporting

confidence: 70%

Section: Inclusion/exclusion Criteriamentioning

confidence: 99%

Long-term effects of continuous theta-burst stimulation in visuospatial neglect

Song

Zhang

et al. 2015

J Int Med Res

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“…Fifteen additional RCTs investigating neglect were found that were not included in those reviews (prism adaptation, 2; virtual reality, 2; limb activation, 2; neck vibration with prism adaptation, 1; visual scanning with limb activation, 1; mental practice, 1; repetitive transcranial magnetic stimulation, 4; and optokinetic stimulation, 2). [471][472][473][474][475][476][477][478][479][480][481][482][483] There is evidence for the efficacy of several top-down and bottom-up approaches in improving both immediate performance and long-term performance on standard neglect tests such as cancellation tests and line bisection tests. * These include half-field eye patching, visual scanning training, prism adaptation, limb activation, optokinetic stimulation, mental imagery (but see the work by Welfringer and colleagues 482 ), and brain stimulation with repetitive transcranial magnetic stimulation, theta burst transcranial magnetic stimulation, or tDCS.…”

Section: Hemispatial Neglect or Hemi-inattentionmentioning

confidence: 99%

Guidelines for Adult Stroke Rehabilitation and Recovery

Winstein¹,

Stein²,

Arena

et al. 2016

Stroke

1,937

840

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e98Purpose-The aim of this guideline is to provide a synopsis of best clinical practices in the rehabilitative care of adults recovering from stroke. Methods-Writing group members were nominated by the committee chair on the basis of their previous work in relevant topic areas and were approved by the American Heart Association (AHA) Stroke Council's Scientific Statement Oversight Committee and the AHA's Manuscript Oversight Committee. The panel reviewed relevant articles on adults using computerized searches of the medical literature through 2014. The evidence is organized within the context of the AHA framework and is classified according to the joint AHA/American College of Cardiology and supplementary AHA methods of classifying the level of certainty and the class and level of evidence. The document underwent extensive AHA internal and external peer review, Stroke Council Leadership review, and Scientific Statements Oversight Committee review before consideration and approval by the AHA Science Advisory and Coordinating Committee. Results-Stroke rehabilitation requires a sustained and coordinated effort from a large team, including the patient and his or her goals, family and friends, other caregivers (eg, personal care attendants), physicians, nurses, physical and occupational therapists, speech-language pathologists, recreation therapists, psychologists, nutritionists, social workers, and others. Communication and coordination among these team members are paramount in maximizing the effectiveness

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“…In the Shindo et al (2006) study, six sessions of rTMS improved the performance of two right brain-damaged patients on several subtests of the Behavioral Inattention Test (BIT) up to 6 weeks after treatment. After a single low-frequency rTMS session, Koch et al (2008) observed an improvement in the naming of visual chimeric figures in 12 right brain-damaged patients and in the Song et al (2009) trial, two sessions of rTMS per day during 14 days ameliorated line bisection and line cancelation for up to 14 days after treatment in 7 patients with right brain damage. Lim et al (2010) gave 1 Hz trains of 900 pulses for 5 days per week during 2 weeks to seven patients with right brain damage.…”

Section: Non-invasive Brain Stimulationmentioning

confidence: 99%

“…Other studies with small right brain lesioned patient groups and no control condition, using low-frequency rTMS inhibiting the left parietal cortex are those of Shindo et al (2006), Koch et al (2008), Song et al (2009), andLim et al (2010). In the Shindo et al (2006) study, six sessions of rTMS improved the performance of two right brain-damaged patients on several subtests of the Behavioral Inattention Test (BIT) up to 6 weeks after treatment.…”

Section: Non-invasive Brain Stimulationmentioning

confidence: 99%

Novel insights in rehabilitation of neglect

2014

Frontiers Research Topics

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Visuospatial neglect due to right hemisphere damage, usually a stroke, is a major cause of disability, impairing the ability to perform a whole range of everyday life activities. Conventional and long-established methods for the rehabilitation of neglect like visual scanning training, optokinetic stimulation, or limb activation training have produced positive results, with varying degrees of generalization to (un)trained tasks, lasting from several minutes up to various months after training. Nevertheless, some promising novel approaches to the remediation of left visuospatial neglect have emerged in the last decade.These new therapy methods can be broadly classified into four categories. First, non-invasive brain stimulation techniques by means of transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS), after a period of mainly diagnostic utilization, are increasingly applied as neurorehabilitative tools. Second, two classes of drugs, dopaminergic and noradrenergic, have been investigated for their potential effectiveness in rehabilitating neglect. Third, prism adaptation treatment has been shown to improve several neglect symptoms consistently, sometimes during longer periods of time. Finally, virtual reality technologies hold new opportunities for the development of effective training techniques for neglect. They provide realistic, rich, and highly controllable training environments. In this paper the degree of effectiveness and the evidence gathered to support the therapeutic claims of these new approaches is reviewed and discussed. The conclusion is that for all these approaches there still is insufficient unbiased evidence to support their effectiveness. Further neglect rehabilitation research should focus on the maintenance of therapy results over time, on a more functional evaluation of treatment effects, on the design and execution of true replication studies and on the exploration of optimal combinations of treatments.

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Low-frequency transcranial magnetic stimulation for visual spatial neglect: A pilot study

Cited by 90 publications

References 11 publications

Long-term effects of continuous theta-burst stimulation in visuospatial neglect

Long-term effects of continuous theta-burst stimulation in visuospatial neglect

Guidelines for Adult Stroke Rehabilitation and Recovery

Novel insights in rehabilitation of neglect

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