Low-frequency repetitive transcranial magnetic stimulation inhibits the development of methamphetamine-induced conditioned place preference

rTMS-Induced Changes in Glutamatergic and Dopaminergic Systems: Relevance to Cocaine and Methamphetamine Use Disorders

“…LF stimulation, but not HF stimulation, significantly inhibited methamphetamine-induced CPP (Wu et al, 2018b). In addition, the expression of GABA B receptor subunit 1 (R1), but not subunit 2 (R2), in the dorsolateral striatum was significantly decreased in the methamphetamine + 1-Hz rTMS group compared to sham (Wu et al, 2018b). Interestingly, GABA B R1 in the dorsal striatum has been linked with rewarding memories of drugs (Jiao et al, 2016) and may be associated with the ability of LF-rTMS to inhibit drug-induced CPP.…”

“…After 4 days of conditioning, CPP was tested three times (2, 4, and 6 days after the end of the conditioning/treatment period). LF stimulation, but not HF stimulation, significantly inhibited methamphetamine-induced CPP (Wu et al, 2018b). In addition, the expression of GABA B receptor subunit 1 (R1), but not subunit 2 (R2), in the dorsolateral striatum was significantly decreased in the methamphetamine + 1-Hz rTMS group compared to sham (Wu et al, 2018b).…”

“…The only other studies of rTMS in an animal model of addiction that we are aware of investigated how rTMS affected the development of methamphetamine-induced conditioned place preference (CPP) and the reinstatement of CPP after extinction (Wu et al, 2018a,b). The stimulation site in one study was between bregma and lambda skull sutures (Wu et al, 2018a) and was not reported in the second study (Wu et al, 2018b). However, large size of the stimulating coils (circular coil: 5cm outer diameter, 2.5-cm inner diameter) relative to the size of a rat still means that the whole brain (i.e.…”

“…In the experiment testing the development of methamphetamine-induced CPP, rTMS, or sham stimulation was given prior to a methamphetamine injection and placement in a conditioning chamber (Wu et al, 2018b). After 4 days of conditioning, CPP was tested three times (2, 4, and 6 days after the end of the conditioning/treatment period).…”

“…The other experiment looked at the effect of HF-rTMS on methamphetamine relapse behavior (Wu et al, 2018a). After the extinction of CPP behavior, rats were given rTMS for either 1 or 3 days.…”