Low-frequency repetitive magnetic stimulation suppresses neuroblastoma progression by downregulating the Wnt/β-catenin signaling pathway

Jo, Seongmoon; Im, Sang Hee; Seo, Dongryul; Ryu, Hayeon; Kim, Sung Hoon; Baek, Dae-Hyun; Baek, Ahreum; Cho, Sung Rae

doi:10.1016/j.bioelechem.2022.108205

Cited by 4 publications

(3 citation statements)

References 45 publications

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“…The aberrant activation of the Wnt/β-catenin pathway is critically involved in the pathogenesis of various cancers, including NB [18]. Investigations have illuminated that the constituents of the Wnt/β-catenin signaling pathway, including the activation of Wnt ligands such as WNT1, WNT2, and WNT5A, and the maladjustment of β-catenin, a pivotal downstream effector, contribute to NB progression [19]. KRAS mutations are implicated in approximately 25% of human cancers.…”

Section: Discussionmentioning

confidence: 99%

Potential Cause-and-Effect Relationship between Gut Microbiota and Childhood Neuroblastoma: A Mendelian Randomization Analysis

Chu

2024

Indian J Pediatr

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Objectives To analyze the potential causal-effect of gut microbiota (GM) on neuroblastoma (NB) risk using a Mendelian randomization (MR) study. Methods A two-sample MR study was conducted using summary statistics of the GM from the largest available meta-analysis of genome-wide association studies conducted by the MiBioGen consortium. Pooled statistics for childhood NB were obtained from the IEU Consortium release data (1627 cases and 3254 controls). Inverse variance-weighted, weighted median, MR-Egger, and weighted mod were used to examine the causal relationship between GM and childhood NB. Single-nucleotide polymorphism (SNP) genes of positive GM were extracted using the PLINK program, and correlations between key SNP genes and tumor-regulated genes were analyzed. Functional enrichment analysis and transcription factor prediction were performed. Results Inverse variance weighted (IVW) results indicated that Erysipelotrichia exerted a protective effect against childhood NB (odds ratio = 0.371, 95% Confidence interval: 0.173 - 0.795, P = 0.011) and that Oscillospira exerted a risk effect against childhood NB (odds ratio = 2.378, 95% Confidence interval: 1.121 - 5.043, P = 0.024), indicating the association of GM with childhood NB. Further screening analysis using the IVW test revealed a reliable causal relationship between Erysipelotrichia and NB. Two SNP genes (MUC4 and PELI2) of Erysipelotrichia were extracted and analyzed. Both key genes were significantly associated with tumor-regulated genes, enriched in several pathways associated with tumor progression, and correlated with several upstream transcription factors. Conclusions It was observed that Erysipelotrichia is causally associated with NB using a two-sample MR study. Furthermore, the discovery of two SNP genes, MUC4 and PELI2, provides potential targets for the diagnosis and treatment of NB.

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Section: Discussionmentioning

confidence: 99%

Potential Cause-and-Effect Relationship between Gut Microbiota and Childhood Neuroblastoma: A Mendelian Randomization Analysis

Chu

2024

Indian J Pediatr

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“…The Wnt/β-catenin signaling pathway is involved in the response to oxidative stress stimuli and leads to white matter lesions and central nervous system in ammation and injury [20][21][22], and inhibition of the abnormal activation of the Wnt/β-catenin signaling pathway was shown to delay coronary artery disease (CAD) in the myocardial tissue of rats [23] and the process of RI/R injury involving oxidative stress in the kidney [24]. Inhibition of the Wnt/β-catenin signaling pathway inhibited the progression of neuroblastoma and attenuated axonal degeneration in Parkinson's disease models [15,16,25]. These studies suggest that activation of Wnt/β-catenin signaling promotes disease, and inhibition of Wnt/β-catenin signaling may have a protective effect.…”

Section: Discussionmentioning

confidence: 99%

Exosomal miR-320e is a potential target of CVSD that regulates the Wnt2-mediated Wnt/β-catenin signaling pathway

Wang

Yang

et al. 2023

Preprint

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Exosomal miRNAs play crucial roles in many central nervous system diseases. Cerebral small vessel disease (CVSD) is a small vessel disease thatis affected by various factors. In the present study, we investigated the role of exosomal miR-320e in theWnt/β-catenin pathway stimulated by oxidative stress and assessed its role in CVSD. The differentially expressed exosomal miRNAs were filtered by sequencing plasma exosomes from CVSD patients and healthy controls. Bioinformatic and dual luciferase analyses were used to confirm the relationship between Wnt2 and miR-320e. Quantitative real-time PCR and Western blotting were used to detect the mRNA and protein levels of Wnt/β-catenin pathway components. Membrane fluorescence staining was used to detect exosome transfer. High-throughput sequencing showed that exosomal miR-320e was downregulated. Bioinformatics analysis and dual-luciferase reporter gene experiments showed that exosomal miR-320e regulated Wnt2expression by targeting the 3' noncodingregion of Wnt2. Exosomal miR-320e was found to mediate the response of the Wnt/β-catenin signaling pathway to oxidative stress through loss-of-function experiments using mimics, inhibitors and knockdown/overexpression lentivirus. Exosomal miR-320e could target and inhibit the Wnt2/β-catenin signaling pathway. Our research suggests that exosomal miR-320e is a suppressor of the Wnt/β-catenin signaling pathway and may play a protective role in the progression of CVSD. Clinical trial registration Not applicable

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“…Inhibition of the abnormal activation of the Wnt/β-catenin pathway was shown to delay coronary artery disease in the myocardial tissue of rats[ 29 ] and the process of renal ischaemia-reperfusion injury involving oxidative stress in the kidney[ 30 ]. Inhibition of the Wnt/β-catenin pathway also inhibited the progression of neuroblastoma and attenuated axonal degeneration in Parkinson's disease models[ 20 , 21 , 31 ]. However, studies on the involvement of the Wnt/β-catenin pathway in CVSD are lacking.…”

Section: Discussionmentioning

confidence: 99%

Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment

Wang,

Li,

Yang

et al. 2023

World J Psychiatry

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Deep transcranial magnetic stimulation (DTMS) is a new non-invasive neuromodulation technique based on repetitive transcranial magnetic stimulation technology. The new H-coil has significant advantages in the treatment and mechanism research of psychiatric and neurological disorders. This is due to its deep stimulation site and wide range of action. This paper reviews the clinical progress of DTMS in psychiatric and neurological disorders such as Parkinson’s disease, Alzheimer’s disease, post-stroke motor dysfunction, aphasia, and other neurological disorders, as well as anxiety, depression, and schizophrenia.

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Low-frequency repetitive magnetic stimulation suppresses neuroblastoma progression by downregulating the Wnt/β-catenin signaling pathway

Cited by 4 publications

References 45 publications

Potential Cause-and-Effect Relationship between Gut Microbiota and Childhood Neuroblastoma: A Mendelian Randomization Analysis

Potential Cause-and-Effect Relationship between Gut Microbiota and Childhood Neuroblastoma: A Mendelian Randomization Analysis

Exosomal miR-320e is a potential target of CVSD that regulates the Wnt2-mediated Wnt/β-catenin signaling pathway

Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment

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