Low frequency perforant path stimulation as a conditioned stimulus demonstrates correlations between long-term synaptic potentiation and learning

Matthies, H; Ruethrich, Heinz; Ott, Tilmann; Matthies, H; Matthies, Renate

doi:10.1016/0031-9384(86)90436-1

Cited by 47 publications

(7 citation statements)

References 62 publications

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“…We use the terms "early-LTP" for an initial phase of LTP with a 4-5-h duration that is protein synthesis-independent, and "late-LTP" for a late phase that protein synthesis-dependently maintains over more than 8 h. As pointed out by Kelleher III et al (2004), these temporal phases of LTP were initially described by Krug et al (1984) and Frey et al (1988) and were confirmed by others in vivo (Otani and Abraham 1989;Otani and Ben-Ari 1993) and in vitro (Huang et al 1994). It was shown that this kind of early-LTP is reinforceable in vivo; that is, it can protein synthesisdependently be transformed into late-LTP (Matthies et al 1986), by a temporal-related second heterosynaptic input (Seidenbecher et al 1997;Frey et al 2001;Straube et al 2003b). The induction of this form of LTP, in contrast to a short-term potentiation (Frey and Morris 1997), sets a tag at the potentiated synapses that then can profit from plasticity-related proteins, the synthesis of which was induced by the modulatory heterosynaptic inputs.…”

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confidence: 65%

Reinforcement of rat hippocampal LTP by holeboard training

Uzakov¹,

Frey²,

Korz

2005

Learn. Mem.

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Hippocampal long-term potentiation (LTP) can be dissociated in early-LTP lasting 4-5 h and late-LTP with a duration of more than 8 h, the latter of which requires protein synthesis and heterosynaptic activity during its induction. Previous studies in vivo have shown that early-LTP in the dentate gyrus can protein synthesis-dependently be transformed (reinforced) into late-LTP by the association of arousing novel environmental stimuli. Here we show that consolidation of spatial memory also reinforces early-LTP in the dentate gyrus. Both memory consolidation and LTP-reinforcement depend on protein synthesis. Four groups of animals were trained by five, seven, eight or 10 trials, respectively, to recognize a fixed pattern of baited holes. The last trial was performed 15 min after tetanus. Errors of long-term reference memory during the last trial were significantly decreased only in the eight-and 10-trial experimental groups compared to pseudo-trained animals. In correlation to this learning effect we found a reinforcement of early-LTP only in these experimental groups compared to controls. The data suggest that the synthesis of new proteins required for spatial reference-memory formation also contributes to LTP maintenance in the hippocampal dentate gyrus.Long-term potentiation (LTP), a widely studied cellular model for learning and memory formation, can-similar to memory forma tion (Flexner et al. 1965;Grecksch and Matthies 1980;Izquierdo et al. 2002)-be dissociated into an early phase and a late phase. We use the terms "early-LTP" for an initial phase of LTP with a 4-5-h duration that is protein synthesis-independent, and "late-LTP" for a late phase that protein synthesis-dependently maintains over more than 8 h. As pointed out by Kelleher III et al. (2004), these temporal phases of LTP were initially described by Krug et al. (1984) and Frey et al. (1988) and were confirmed by others in vivo (Otani and Abraham 1989;Otani and Ben-Ari 1993) and in vitro (Huang et al. 1994). It was shown that this kind of early-LTP is reinforceable in vivo; that is, it can protein synthesisdependently be transformed into late-LTP (Matthies et al. 1986), by a temporal-related second heterosynaptic input (Seidenbecher et al. 1997;Frey et al. 2001;Straube et al. 2003b). The induction of this form of LTP, in contrast to a short-term potentiation (Frey and Morris 1997), sets a tag at the potentiated synapses that then can profit from plasticity-related proteins, the synthesis of which was induced by the modulatory heterosynaptic inputs. Thus, the processing of the newly synthesized plasticity-related proteins by the tagged synapses allows the transformation of early-LTP into late-LTP. This is essential for reinforcement processes. There is a large body of literature reporting that the maintenance of memories also requires heterosynaptic activation (for review, see Bailey et al. 2000). Late-LTP is considered to be related to long-term memory, whereas early-LTP may represent short-term memory traces (Bach et al. 1999;Jones et al. 2001). T...

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confidence: 65%

Reinforcement of rat hippocampal LTP by holeboard training

Uzakov¹,

Frey²,

Korz

2005

Learn. Mem.

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“…However, several detectability studies have employed a methodology that might be regarded as a halfway house between detectability and mimicry. Studies in which sensory stimulation is replaced with electrical stimulation of a particular neural pathway, either as a discriminative cue (Roman et al, 1987(Roman et al, , 1993Chaillan et al, 1999;Mouly et al, 2001) or a conditioned stimulus (Matthies et al, 1986;Laroche et al, 1989;Doyère and Laroche, 1992), fall into this category. In such experiments, post-training LTP-like changes in evoked potentials are often found in response to stimulation of the same pathway that was stimulated during learning.…”

Section: Mimicrymentioning

confidence: 99%

New life in an old idea: The synaptic plasticity and memory hypothesis revisited

2002

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ABSTRACT:The notion that changes in synaptic efficacy underlie learning and memory processes is now widely accepted, although definitive proof of the synaptic plasticity and memory hypothesis is still lacking. This article reviews recent evidence relevant to the hypothesis, with particular emphasis on studies of experience-dependent plasticity in the neocortex and hippocampus. In our view, there is now compelling evidence that changes in synaptic strength occur as a consequence of certain forms of learning. A major challenge will be to determine whether such changes constitute the memory trace itself or play a less specific supporting role in the information processing that accompanies memory formation. Hippocampus 2002;12:609 -636.

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“…A growing body of evidence links LTP and memory. This evidence is based, not only on the suggestive and numerous analogies between both phenomena but also on direct experiments demonstrating a relation between changes in synaptic efficacy and memory in different brain structures as well (Bergado et al., 1988; Matthies et al, 1986;Rioult-Pedotti et al, 1998;Rogan et al, 1997) (for a recent review on the subject see Martin & Morris, 2002). It is plausible, therefore, that age-related disorders in synaptic plasticity might be functionally linked to memory impairment (Shapiro, 2001).…”

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confidence: 99%