Low frequency oscillatory activity of the subthalamic nucleus is a predictive biomarker of compulsive-like cocaine seeking

Degoulet, Mickael; Tiran-Cappello, Alix; Baunez, Christelle; Pelloux, Yann

doi:10.1101/451203

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…As such, our findings that STN lesions increase motor impulsivity while reducing risky or impulsive decisions match well with the literature (for review Eagle & Baunez, 2010). This reduced choice for risky options fits also well with the reduced addiction-risky-related behaviour towards cocaine and heroin after STN lesions or DBS (Degoulet, Tiran-Cappello, Baunez*, & Pelloux*, 2019;Pelloux et al, 2018;Wade et al, 2017).…”

Section: Discussionsupporting

confidence: 88%

Decreased risk‐taking and loss‐chasing after subthalamic nucleus lesion in rats

Breysse

Meffre

Pelloux

et al. 2020

Eur J of Neuroscience

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The subthalamic nucleus (STN) is known to play a role in the control of impulsivity of action and in impulsivity of choice under certain conditions. In order to assess its influence on decision-making under uncertainty, we have tested here the effects of bilateral STN lesions in rats performing a probability discounting task (PDT) and a "loss-chasing" task, both tasks assessing risky decision under uncertainty, but one in a positive context (probability to obtain a larger reward) and the other in a negative context (risk for a larger loss). The PDT measures the choice between a small certain and a large uncertain reward. Conversely, in the "loss-chasing" task, animals choose between accepting a small certain loss versus risking a larger but uncertain penalty.The results show that STN lesions reduce risk-taking in both the PDT and the losschasing task, suggesting that STN inactivation could decrease risky decision-making whatever the nature of the outcome in an ambiguous context. Interestingly, opposite results were found in a small number of animals for which the lesions extended to the area dorsal to the STN (in the zona incerta), such that these animals increased choice of the uncertain option in the PDT. These results confirm the specificity of STN involvement in these processes and may provide explanations for some side-effects reported in patients when STN manipulations extend to the Zona Incerta. They also support the choice of the STN as a target for the treatment of impulse control disorders in Parkinson's disease and in obsessive compulsive disorders.

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Section: Discussionsupporting

confidence: 88%

Decreased risk‐taking and loss‐chasing after subthalamic nucleus lesion in rats

Breysse

Meffre

Pelloux

et al. 2020

Eur J of Neuroscience

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Consolidating the Circuit Model for Addiction

Lüscher

Janak

2021

Annu. Rev. Neurosci.

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Addiction is a disease characterized by compulsive drug seeking and consumption observed in 20–30% of users. An addicted individual will favor drug reward over natural rewards, despite major negative consequences. Mechanistic research on rodents modeling core components of the disease has identified altered synaptic transmission as the functional substrate of pathological behavior. While the initial version of a circuit model for addiction focused on early drug adaptive behaviors observed in all individuals, it fell short of accounting for the stochastic nature of the transition to compulsion. The model builds on the initial pharmacological effect common to all addictive drugs—an increase in dopamine levels in the mesolimbic system. Here, we consolidate this early model by integrating circuits underlying compulsion and negative reinforcement. We discuss the genetic and epigenetic correlates of individual vulnerability. Many recent data converge on a gain-of-function explanation for circuit remodeling, revealing blueprints for novel addiction therapies. Expected final online publication date for the Annual Review of Neuroscience, Volume 44 is July 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Low frequency oscillatory activity of the subthalamic nucleus is a predictive biomarker of compulsive-like cocaine seeking

Cited by 2 publications

References 51 publications

Decreased risk‐taking and loss‐chasing after subthalamic nucleus lesion in rats

Decreased risk‐taking and loss‐chasing after subthalamic nucleus lesion in rats

Consolidating the Circuit Model for Addiction

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