Low frequency of human papillomavirus infection in conjunctival squamous cell carcinoma of Mexican patients

Peralta, Raúl; Valdivia, Alejandra; Estañol, Perla; Villegas, Vanessa; Pimienta, Carolina; Treviño, Eugenio; Marrero, Daniel; Mendoza, Mónica; Jimenez, Florinda; Villalvazo, Leonardo; Tejeda, Miriam; Salcedo, Mauricio

doi:10.1186/1750-9378-6-24

Cited by 13 publications

(14 citation statements)

References 27 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early investigations detected HPV, but several recent studies have not identified the virus in CIN or cSCC lesions, calling its role in the initiation and growth of these tumors into question. [7][8][9] The strong association between OSSN and exposure to sunlight, however, is clear, with a striking increase in their incidence in geographic areas that are close to the equator. 4,10,11 In addition, patients with xeroderma pigmentosum, who are more susceptible to the effects of solar UV light due to mutation or loss of DNA repair factors, are especially prone to develop the disease.…”

mentioning

confidence: 99%

Identification of Multiple DNA Copy Number Alterations Including Frequent 8p11.22 Amplification in Conjunctival Squamous Cell Carcinoma

Asnaghi

Alkatan

Mahale

et al. 2014

Investigative Ophthalmology & Visual Science

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Identification of Multiple DNA Copy Number Alterations Including Frequent 8p11.22 Amplification in Conjunctival Squamous Cell Carcinoma

Asnaghi

Alkatan

Mahale

et al. 2014

Investigative Ophthalmology & Visual Science

View full text Add to dashboard Cite

show abstract

“…This study focused on two geographically separate regions of México: NE and SC (approximately 700 km apart). In the USA, Europe, Sub-Saharan Africa, Latin America and the Caribbean [13][14][15][16], as well as in most Mexican populations investigated so far, HPV 16 has been found to be the most prevalent of the highrisk HPV types in oncogenic malignancies and in asymptomatic women [17]. Our results show this also to be the case in the NE region (with a prevalence of HPV type 16 of 37%/38% in women/men), but not in the SC region (where it was 15%/ 11.5% in women/men).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus types in North and Central regions of Mexico

Luna-Aguirre¹,

Reyes-Cortes²,

Torres-Grimaldo³

et al. 2018

Epidemiol. Infect.

View full text Add to dashboard Cite

Human papillomavirus (HPV) is a DNA virus linked to mucosal and cutaneous carcinogenesis. More than 200 different HPV types exist. We carried out a transversal study to investigate the prevalence of HPV types in two regions of Mexico. A total of 724 genital and non-genital samples from women (F) and men (M) were studied; 241 (33%) from North-Eastern (NE) and 483 (66%) from South-Central (SC) Mexico. The overall prevalence was 87%. In genital lesions from females, the NE group showed a prevalence of HPV types 16 (37%), 6 (13%), 59 (6%), 11, 18 and 66 (5.4% each); and the SC group showed types 6 (17%), 16 (15%), 11 (14.5%), 18 (12%) and 53 (6%). In the genital lesions from males, NE group showed types 16 (38%), 6 (21%), 11 (13%) and 59 plus 31 (7.5%) and the SC group showed types 6 (25%), 11 (22%), 18 (17%) and 16 (11.5%). When the two regions were compared, a higher prevalence of low-risk HPV 6 and 11 was found in the SC region and of high-risk HPV 59, 31 and 66 (the latter can also be present in benign lesions) in the NE region. Our findings complement efforts to understand HPV demographics as a prerequisite to guide and assess the impact of preventive interventions.

show abstract

“…In one set of studies done in both Africa and the United States, evidence of HPV infection was found in most CSCC tumor samples . In contrast, another set of studies from Africa as well as from other regions of the world such as the United States, Germany, Brazil, and Mexico has found no evidence of HPV in CSCC . In addition, prognostic tumor biomarkers like cyclin D, p16, estimated glomerular filtration rate (EGFR), and p53 have been described in CSCC in the United States, but these are not well studied in CSCC in Africa…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana

Merz

Afriyie

Jiagge

et al. 2019

Health Science Reports

View full text Add to dashboard Cite

Background and aims Conjunctival squamous cell carcinoma (CSCC) varies in incidence geographically from 0 to 1 case per 100 000 per year globally. Additionally, the incidence of CSCC is known to increase 49% for every 10° decrease in latitude. Since the onset of the AIDS epidemic, there has been a trend of increasing incidence of CSCC in Africa, and despite relatively stable levels of ultraviolet (UV) exposure, there is an observed 12 times greater risk of developing CSCC when individuals are infected with HIV. In this study, we aim to analyze the clinical characteristics and biomarkers of CSCC in Ghana. Methods In this study, a registry review of patients from January 2011 to May 2016 with CSCC at Komfo‐Anokye Teaching Hospital in Kumasi, Ghana, was performed (n = 64). Tumor blocks of the CSCC were analyzed for the expression of various biomarkers. Results In this study, the median age of onset of CSCC is 46.5 years old (range of 20–90 y old). Fifty one and a half percent (n = 33) of the cohort is female. There is a low rate of smoking and alcohol use in our CSCC cohort. Thirty‐nine percent (n = 12) of Ghanaian men with CSCC are HIV−, while only 12% (n = 4) of women are HIV−. Fifteen patients had metastasis to lymph nodes or other tissues, and we observed a statistically significant relationship between HIV infection and metastasis (P = 0.027, chi‐squared test). We observed no statistically significant relationship between known prognostic CSCC biomarkers and HIV status, age, or tumor stage. Conclusion Better characterization of CSCC could have a profound impact on the prevention, early identification, and treatment of CSCC in Africa. A retrospective chart analysis and collection of tumor samples can be challenging in this region due to methods of record keeping and stigma attached to clinical data such as HIV testing and smoking and alcohol use. As a result, in this study, data were often incomplete leading to inconclusive results and analysis that should be interpreted with caution. Future studies should consider a prospective study design that gathers clinical data in a standardized format and ensures fresh tissue from CSCC tumors.

show abstract

Low frequency of human papillomavirus infection in conjunctival squamous cell carcinoma of Mexican patients

Cited by 13 publications

References 27 publications

Identification of Multiple DNA Copy Number Alterations Including Frequent 8p11.22 Amplification in Conjunctival Squamous Cell Carcinoma

Identification of Multiple DNA Copy Number Alterations Including Frequent 8p11.22 Amplification in Conjunctival Squamous Cell Carcinoma

Prevalence of human papillomavirus types in North and Central regions of Mexico

Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana

Contact Info

Product

Resources

About