Low frequency of HLA-B27 in ankylosing spondylitis patients from Turkey

Low frequency of HLA-B27 in ankylosing spondylitis and its relationship with clinical findings in patients from Turkey

“…In our study, the male to female ratio was 2.5. In a study conducted, by Feldtkeller et al (10), the onset age of AS patients was found to be 25.1±8.5 years; however, it was 23.5±8.9 years in a Turkish population-based study (6). In our study, the mean age of disease onset in AS patients was found to be 28.3±9.0 years, similar with the findings of the previous studies.…”

“…The highest HLA-B27 positivity is observed in American Indians; however, HLA-B27 positivity is found 50% maximum in Canadian Haida people, and it is relatively lower in African Americans (5). In our country, HLA-B27 positivity was found to be 70% in AS patients (6).…”

Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis

“…The rate of HLA-B27 varies in different studies in Turkey. Gunal et al (22) and Cinar et al (23) reported that the proportion of HLA-B27 positivity was 70.0% and 66.7%. Although HLA-B27 rate was lower than expected and determined as 32.3% on patients.…”

“…Various genetic and environmental factors may contribute to the decreased HLA-B27 frequency observed among Turkish AS patients. Sample size also plays a role (22).…”

The Distribution of HLA B27 in Patients with Ankylosing Spondylitis in Eastern Anatolia

“…In the study of Kasapoglu et al carried out with 112 AS patients, HLA B27 positivity was found as 70%. 9 In Turkey carried out by the TRASD AS study group on 262 patients, HLA B27 positivity was found as 73.7%. This ratio was 7-8% in healthy individuals.…”