Low-frequency fatigue and neuromuscular performance after exercise-induced damage to elbow flexor muscles

Dundon, James M.; Cirillo, John; Semmler, John G.

doi:10.1152/japplphysiol.01339.2007

Cited by 46 publications

(74 citation statements)

References 40 publications

(85 reference statements)

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“…This increase in unsteadiness has been reported in the upper extremity both during as well as after sustained contractions (Maughan et al 1986;Huang et al 2006;Contessa et al 2009) and after repetitive fatiguing tasks (Dartnall et al 2008;Dundon et al 2008). However, except for a few studies on fatigue during sustained contractions (Maughan et al 1986;Clark et al 2005), the relationship between fatigue and unsteadiness in the lower extremity, and therefore during functional activities, remains uninvestigated.…”

Section: Introductionmentioning

confidence: 88%

Effect of fatigue on force fluctuations in knee extensors in young adults

Singh

Arampatzis

Duda

et al. 2010

Phil. Trans. R. Soc. A.

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This study investigated the hypothesis that fatiguing exercises led to increased force fluctuations during submaximal isometric knee extensions and to decreased accuracy and steadiness in the time and frequency domains. Sixteen young adults (eight males, eight females) were tested, in a seated posture with 90°knee flexion, to assess their ability to reproduce target extensor torques set at 15 per cent and 20 per cent of their maximum voluntary isometric contraction, both before and after fatiguing exercises. Normalized mean (NMAE) and peak (NPAE) of the absolute error were both used to quantify accuracy, whereas normalized standard deviation of the absolute error (NSAE) was used to quantify steadiness of the torque trials in the time domain. Mean and median power frequencies (MnPF, MdPF) and normalized peak power (NPkP) were used to assess the spectral structure of the torque signals. NMAE, NSAE and NPAE all showed excellent intra-as well as intersession reliabilities (intraclass correlation values greater than 0.75 and low standard error of measurement values), demonstrating repeatability of the test set-up. NMAE, NSAE and NPAE increased significantly postfatigue (greater than 42%), together with a shift towards higher frequency (MnPF and MdPF) components, indicating that the set-up was sensitive enough to detect the decreased force accuracy and steadiness of the musculature after fatigue. Increased force variability in both the time and frequency domains could therefore explain decreased steadiness after fatigue.

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Section: Introductionmentioning

confidence: 88%

Effect of fatigue on force fluctuations in knee extensors in young adults

Singh

Arampatzis

Duda

et al. 2010

Phil. Trans. R. Soc. A.

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“…The experimental procedure was replicated in each of these sessions and involved elbow flexion tasks, electrical stimulation of the brachial plexus, and TMS. The session 2 h after eccentric exercise was performed to examine the changes in intracortical inhibition after eccentric exercise in the presumed absence of metabolic fatigue, as we have shown previously that a similar decline in maximal strength recovers within 2 h following concentric but not eccentric exercise (18). The session 2 days after eccentric exercise coincided with the peak in DOMS (44).…”

Section: Methodsmentioning

confidence: 99%

“…These changes include a prolonged decline in muscle strength, a shift in the optimal joint angle to produce peak torque to longer muscle lengths, changes in the relaxed elbow joint angle that are indicative of increased passive muscle tension, and an increase in muscle soreness 2 days after the exercise. Changes in these and other markers of muscle damage are not observed after concentric exercise, which produces a short-lasting decline in muscle strength with minimal muscle damage (10,18,55). The decline in muscle strength after concentric exercise primarily results from metabolic fatigue in the muscle (19) with recovery of strength within 2 h (18,26,38).…”

Section: Muscle Damage and Neuromotor Performance After Eccentric Exementioning

confidence: 99%

“…Changes in these and other markers of muscle damage are not observed after concentric exercise, which produces a short-lasting decline in muscle strength with minimal muscle damage (10,18,55). The decline in muscle strength after concentric exercise primarily results from metabolic fatigue in the muscle (19) with recovery of strength within 2 h (18,26,38). In contrast, muscle strength after eccentric exercise can take 1 wk or more to recover (11) and is considered to be one of the most reliable indicators of muscle damage in humans (58).…”

Section: Muscle Damage and Neuromotor Performance After Eccentric Exementioning

confidence: 99%

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Reduced short-interval intracortical inhibition after eccentric muscle damage in human elbow flexor muscles

Pitman

Semmler

2012

Journal of Applied Physiology

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Pitman BM, Semmler JG. Reduced short-interval intracortical inhibition after eccentric muscle damage in human elbow flexor muscles. J Appl Physiol 113: 929 -936, 2012. First published July 26, 2012 doi:10.1152/japplphysiol.00361.2012.-The purpose of this study was to use paired-pulse transcranial magnetic stimulation (TMS) to examine the effect of eccentric exercise on short-interval intracortical inhibition (SICI) after damage to elbow flexor muscles. Nine young (22.5 Ϯ 0.6 yr; mean Ϯ SD) male subjects performed maximal eccentric exercise of the elbow flexor muscles until maximal voluntary contraction (MVC) force was reduced by ϳ40%. TMS was performed before, 2 h after, and 2 days after exercise under Rest and Active (5% MVC) conditions with motor-evoked potentials (MEPs) recorded from the biceps brachii (BB) muscle. Peripheral electrical stimulation of the brachial plexus was used to assess maximal Mwaves, and paired-pulse TMS with a 3-ms interstimulus interval was used to assess changes in SICI at each time point. The eccentric exercise resulted in a 34% decline in strength (P Ͻ 0.001), a 41% decline in resting M-wave (P ϭ 0.01), changes in resting elbow joint angle (10°, P Ͻ 0.001), and a shift in the optimal elbow joint angle for force production (18°, P Ͻ 0.05) 2 h after exercise. This was accompanied by impaired muscle strength (27%, P Ͻ 0.001) and increased muscle soreness (P Ͻ 0.001) 2 days after exercise, which is indicative of muscle damage. When the test MEP amplitudes were matched between sessions, we found that SICI was reduced by 27% in resting and 23% in active BB muscle 2 h after exercise. SICI recovered 2 days after exercise when muscle pain and soreness were present, suggesting that delayed onset muscle soreness from eccentric exercise does not influence SICI. The change in SICI observed 2 h after exercise suggests that eccentric muscle damage has widespread effects throughout the motor system that likely includes changes in motor cortex. exercise; motor control; TMS; motor cortex UNACCUSTOMED ECCENTRIC EXERCISE involving the repetitive lengthening of muscle is known to cause significant damage to the ultrastructural and cytoskeletal components of muscle fibers (1) and an impairment in the excitation-contraction coupling process (59). The consequences of this exercise-induced muscle damage are a long-lasting decline in muscle strength, a shift in the optimal muscle length for force generation, muscle swelling, and an increase in passive muscle tension or stiffness (46). Furthermore, muscle pain develops 1 or 2 days after the exercise, which is thought to reflect increased release of noxious chemicals from damaged muscle (39). This delayed onset muscle soreness (DOMS) is not discernible at rest but is elicited under mechanical stimulation such as pressure, stretching, or contraction of the affected muscle (45), which can produce debilitating and long-lasting effects on muscle function (7).Along with these changes in the muscle, several lines of evidence suggest that eccentric muscle damage pro...

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“…Der Muskelschmerz beginnt 6-8 Stunden nach der exzentrischen Belastung, ist nach 24-48 Stunden maximal ausgeprägt (Crameri et al 2001, Connolly et al 2003, Dartnall et al 2008, Dundon et al 2008) und nimmt danach wieder kontinuierlich ab. In der Regel besteht die Schmerzsymptomatik -je nach Ausprägung von DOMS -über einen Zeitraum von 5-8 Tagen (Bottas et al 2009, Philippou et al 2009, Rother et al 2009).…”

Section: Verlaufunclassified