Low-frequency ERK and Akt activity dynamics are predictive of stochastic cell division events
Jamie J. R. Bennett,
Alan D. Stern,
Xiang Zhang
et al.
Abstract:Understanding the dynamics of intracellular signaling pathways, such as ERK1/2 (ERK) and Akt1/2 (Akt), in the context of cell fate decisions is important for advancing our knowledge of cellular processes and diseases, particularly cancer. While previous studies have established associations between ERK and Akt activities and proliferative cell fate, the heterogeneity of single-cell responses adds complexity to this understanding. This study employed a data-driven approach to address this challenge, developing … Show more
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