Low‐frequency electrical stimulation of a fiber tract in temporal lobe epilepsy

Koubeissi, Mohamad Z.; Kahriman, Emine; Syed, Tanvir U.; Miller, Jonathan P.; Durand, Dominique M.

doi:10.1002/ana.23915

Cited by 133 publications

(124 citation statements)

References 41 publications

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“…In contrast to studies that directly targeted hippocampus, these studies often report memory improvements. In one such aDES study, Koubeissi et al (2013) reported that acute lowfrequency stimulation of fornix (200~500 µs wide pulses delivered at 5 Hz continuously during 4-hour sessions) improved Mini-Mental Status Examination (MMSE) scores in eleven patients.…”

Section: Forniceal Stimulationmentioning

confidence: 99%

“…We discuss six aDES studies on memory modulation which provide a useful framework for considering the varying effects of hippocampal stimulation on memory performance (Coleshill et al, 2004;Fell et al, 2013;Koubeissi, Kahriman, Syed, Miller, & Durand, 2013;Lacruz et al, 2010;Miller et al, 2015;Suthana et al, 2012). These studies all used depth electrodes targeting the hippocampus, parahippocampal cortex, or fornix.…”

mentioning

confidence: 99%

“…These studies all used depth electrodes targeting the hippocampus, parahippocampal cortex, or fornix. Most studies used high frequency pulses (40-200 Hz) with one exception (Koubeissi et al, 2013) in which low frequency pulses (5Hz) were used. Patients were tested with a recognition memory task, spatial navigation task, or standardized cognitive batteries that include measures of declarative memory.…”

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confidence: 99%

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A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory

Kim¹,

Ekstrom

Tandon³

2016

Neurobiology of Learning and Memory

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A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. that disrupting frontal or parietal regions also impairs memory performance, suggesting that these regions also play necessary roles in declarative memory. On the other hand, a handful of both invasive and non-invasive studies have also suggested modest improvements in memory performance following stimulation. These studies typically target brain regions connected to the hippocampus or other memory "hubs," which may affect endogenous activity in connected areas like the hippocampus, suggesting that to augment declarative memory, altering the broader endogenous memory network activity is critical. Together, studies reporting memory improvements / impairments are consistent with the idea that a network of distinct brain "hubs" may be crucial for successful memory encoding and retrieval rather than a single primary hub such as the hippocampus. Thus, it is important to consider neurostimulation from the network perspective, rather than from a purely localizationalist viewpoint. We conclude by proposing a novel approach to neurostimulation for declarative memory modulation that aims to facilitate interactions between multiple brain "nodes" underlying memory rather than considering individual brain regions in isolation.

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Section: Forniceal Stimulationmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory

Kim¹,

Ekstrom

Tandon³

2016

Neurobiology of Learning and Memory

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“…4) (Nakagawa and Durand 1991;Barbarosie and Avoli 1997;Librizzi and de Curtis 2003;Tellez Zenteno 2006;Koubeissi et al 2013). Activitydependent changes in excitability, pH, and gap-junction coupling should contribute to the ability of frequent interictal spiking to prevent the occurrence of seizures.…”

Section: Interictal Events and Seizuresmentioning

confidence: 99%

Initiation, Propagation, and Termination of Partial (Focal) Seizures

Curtis

Avoli

2015

Cold Spring Harb Perspect Med

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The neurophysiological patterns that correlate with partial (focal) seizures are well defined in humans by standard electroencephalogram (EEG) and presurgical depth electrode recordings. Seizure patterns with similar features are reproduced in animal models of partial seizures and epilepsy. However, the network determinants that support interictal spikes, as well as the initiation, progression, and termination of seizures, are still elusive. Recent findings show that inhibitory networks are prominently involved at the onset of these seizures, and that extracellular changes in potassium contribute to initiate and sustain seizure progression. The end of a partial seizure correlates with an increase in network synchronization, which possibly involves both excitatory and inhibitory mechanisms.

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“…In epilepsy patients with implanted depth electrodes, low-frequency stimulation of the fornix caused evoked responses in the hippocampus and posterior cingulate gyrus, and was associated with improvement in repeated MiniMental State Examination (MMSE) scores. 53 A blinded, sham-controlled trial of stimulation of an electrode implanted in the unilateral crus of the fornix in 4 patients with epilepsy undergoing depth electrode placement found that theta burst stimulation of the fornix led to evoked potentials in the hippocampus and improved performance on a spatial memory task, but not on verbal memory or naming, which are types of semantic memory. 71 The fornix was chosen as the target for the first clinical trial of DBS in AD.…”

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confidence: 99%

Neuromodulation for restoring memory

Bick¹,

Eskandar²

2016

FOC

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Disorders of learning and memory have a large social and economic impact in today's society. Unfortunately, existing medical treatments have shown limited clinical efficacy or potential for modification of the disease course. Deep brain stimulation is a successful treatment for movement disorders and has shown promise in a variety of other diseases including psychiatric disorders. The authors review the potential of neuromodulation for the treatment of disorders of learning and memory. They briefly discuss learning circuitry and its involvement in Alzheimer disease and traumatic brain injury. They then review the literature supporting various targets for neuromodulation to improve memory in animals and humans. Multiple targets including entorhinal cortex, fornix, nucleus basalis of Meynert, basal ganglia, and pedunculopontine nucleus have shown a promising potential for improving dysfunctional memory by mechanisms such as altering firing patterns in neuronal networks underlying memory and increasing synaptic plasticity and neurogenesis. Significant work remains to be done to translate these findings into durable clinical therapies.

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Low‐frequency electrical stimulation of a fiber tract in temporal lobe epilepsy

Cited by 133 publications

References 41 publications

A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory

A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory

Initiation, Propagation, and Termination of Partial (Focal) Seizures

Neuromodulation for restoring memory

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