Low frequency cMUT technology: Application to measurement of brain movement and assessment of bone quality

Certon, Dominique; Ternifi, Redouane; Boulme, Audren; Legros, Mathieu; Minonzio, Jean‐Gabriel; Talmant, Maryline; Patat, F.; Remeniéras, Jean-Pierre

doi:10.1016/j.irbm.2013.01.009

Cited by 7 publications

(10 citation statements)

References 33 publications

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“…The remaining 10 relevant records comprised nine peer-reviewed original publications [11][12][13][14][15][16][17][18][19] and one conference proceeding. 20 The conference proceeding on 2D speckle tracking was included as we found no associated peer-reviewed article.…”

Section: Resultsmentioning

confidence: 99%

“…18 The remaining studies used two alternative ultrasound techniques. 19,20 Certon et al 19 designed and tested a cMUT for use in TPI, to measure brain motion through the skull. Performing TPI with this cMUT probe is advantageous as it can use a lower frequency and has been able to overcome bone barriers.…”

Section: Summary Of Studiesmentioning

confidence: 99%

“…Performing TPI with this cMUT probe is advantageous as it can use a lower frequency and has been able to overcome bone barriers. 19 Amar et al 20 performed 2D speckle tracking to estimate brain parenchyma movement. Measurements were obtained from a medical ultrasound scanner for this study.…”

Section: Summary Of Studiesmentioning

confidence: 99%

“…Five studies only recruited healthy participants, 11,12,[16][17][18] whilst two recruited patients with depression, 13,15 and another recruited participants over 80 years of age with orthostatic hypertension. 14 Two technical feasibility studies 19,20 did not describe the characteristics of their participants.…”

Section: Study Populationsmentioning

confidence: 99%

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Ultrasound measurement of brain tissue movement in humans: A systematic review

et al. 2019

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Introduction It has long been suggested that ultrasound could be used to measure brain tissue pulsations in humans, but potential clinical applications are relatively unexplored. The aim of this systematic review was to explore and synthesise available literature on ultrasound measurement of brain tissue motion in humans. Methods Our systematic review was designed to include predefined study selection criteria, quality evaluation, and a data extraction pro-forma, registered prospectively on PROSPERO (CRD42018114117). The systematic review was conducted by two independent reviewers. Results Ten studies were eligible for the evidence synthesis and qualitative evaluation. All eligible studies confirmed that brain tissue motion over the cardiac cycle could be measured using ultrasound; however, data acquisition, analysis, and outcomes varied. The majority of studies used tissue pulsatility imaging, with the right temporal window as the acquisition point. Currently available literature is largely exploratory, with measurements of brain tissue displacement over a narrow range of health conditions and ages. Explored health conditions include orthostatic hypotension and depression. Conclusion Further studies are needed to assess variability in brain tissue motion estimates across larger cohorts of healthy subjects and in patients with various medical conditions. This would be important for informing sample size estimates to ensure future studies are appropriately powered. Future research would also benefit from a consistent framework for data analysis and reporting, to facilitate comparative research and meta-analysis. Following standardisation and further healthy participant studies, future work should focus on assessing the clinical utility of brain tissue pulsation measurements in cerebrovascular disease states.

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Section: Resultsmentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 99%

Section: Study Populationsmentioning

confidence: 99%

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Ultrasound measurement of brain tissue movement in humans: A systematic review

et al. 2019

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“…While most IVUS transducers are designed for frequencies greater than 10 MHz, Kilroy and Hossack (2011) have fabricated an IVUS transducer capable of achieving 600 kPa at 1.5 MHz by operating the transducer in a width mode. Furthermore, capacitive micro-machined ultrasonic transducers (CMUTs) have the potential to enable production of low frequency transducers with IVUS compatible dimensions (Certon et al, 2013). As a result, it may be possible to fabricate IVUS transducers capable of emitting frequencies better matched to the lower resonant frequency of larger diameter microbubbles.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Characterization of Transiently Stable Albumin-Coated Microbubbles via a Flow-Focusing Microfluidic Device

Chen

Dhanaliwala

Dixon

et al. 2014

Ultrasound in Medicine & Biology

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We present a method of synthesizing albumin-shelled, large diameter (>10 μm), transiently-stable microbubbles using a flow-focusing microfluidic device (FFMD). Microfluidic device production enables microbubbles to be produced immediately prior to insonation, thus relaxing the requirements for stability. Both reconstituted fractionated bovine serum albumin (BSA) and fresh bovine blood plasma were investigated as shell stabilizers. Microbubble coalescence was inhibited by the addition of either dextrose or glycerol and propylene glycol. Microbubbles were observed to have an acoustic half-life of approximately 6 s. Microbubbles generated directly within a vessel phantom containing flowing blood produced a 6.5 dB increase in acoustic signal within the lumen. Microbubbles generated in real-time upstream of in vitro rat aortic smooth muscle cells under physiological flow conditions successfully permeabilized 58 % of the cells upon insonation at a peak negative pressure of 200 kPa. These results demonstrate that transiently-stable microbubbles produced via flow-focusing microfluidic devices are capable of image enhancement and drug delivery. In addition, successful microbubble production with blood plasma suggests the potential to utilize blood as a stabilizing shell.

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Circular membrane approximation model with the effect of the finiteness of the electrode’s diameter of MEMS capacitive micromachined ultrasonic transducers

Maity

Baishya

2016

Microsyst Technol

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Low frequency cMUT technology: Application to measurement of brain movement and assessment of bone quality

Cited by 7 publications

References 33 publications

Ultrasound measurement of brain tissue movement in humans: A systematic review

Ultrasound measurement of brain tissue movement in humans: A systematic review

Synthesis and Characterization of Transiently Stable Albumin-Coated Microbubbles via a Flow-Focusing Microfluidic Device

Circular membrane approximation model with the effect of the finiteness of the electrode’s diameter of MEMS capacitive micromachined ultrasonic transducers

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