Abstract:Deviations from linearity in the dependence of the logarithm of protein unfolding rates, log k u (f ), as a function of mechanical force, f , measurable in single molecule experiments, can arise for many reasons. In particular, upward curvature in log k u (f ) as a function of f implies that the underlying energy landscape must be multidimensional with the possibility that unfolding ensues by parallel pathways. Here, simulations using the SOP-SC model of a wild type β-sandwich protein and several mutants, with… Show more
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