Low folic acid status and its association with anaemia in urban adolescent girls and women of childbearing age in Sri Lanka

Thoradeniya, Tharanga; Wickremasinghe, Rajitha; Ramanayake, R.P.J.C.; Atukorala, Sunethra

doi:10.1079/bjn20051590

Cited by 45 publications

(59 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since serum folate and vitamin B 12 concentrations reflect the balance of folate and vitamin B 12 intake from diet and other resources, their absorption and excretion, using serum concentrations is more reliable compared to using the data of dietary intake from questionnaire. Since the majority of study participants had serum levels of folate or vitamin B 12 in the lower end of the normal range (defined as <3ng/ml for folate and 200pg/ml for vitamin B 12 ), which is comparable with the levels in populations who lived in the areas without food fortification program (Lehti, 1989; Thoradeniya et al, 2006; Vobecky et al, 1985). As such, the results of our study may not be generalizable to populations with high levels of folate or vitamin B 12 .…”

Section: Discussionmentioning

confidence: 74%

Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood

Liu

et al. 2011

Eur J Clin Nutr

View full text Add to dashboard Cite

Background/Objective One of the speculated mechanisms underlying fetal origin hypothesis of breast cancer is the possible influence of maternal environment on epigenetic regulation, such as changes in DNA methylation of the insulin-like growth factor-2 (IGF2) gene. The aim of the study is to investigate the relationship between folate, vitamin B12 and methylation of the IGF2 gene in maternal and cord blood. Subjects/Methods We conducted a cross-sectional study to measure methylation patterns of IGF2 in promoters 2 (P2) and 3 (P3). Results The percentage of methylation in IGF2 P3 was higher in maternal blood than in cord blood (p<0.0001), while the methylation in P2 was higher in cord blood than in maternal blood (p=0.016). P3 methylation was correlated between maternal and cord blood (p<0.0001) but not P2 (p=0.06). The multivariate linear regression model showed that methylation patterns of both promoters in cord blood were not associated with serum folate levels in either cord or maternal blood, while the P3 methylation patterns were associated with serum levels of vitamin B12 in mother’s blood (MC=−0.22, p=0.0014). Methylation patterns in P2 of maternal blood were associated with serum levels of vitamin B12 in mother’s blood (MC=−0.23, p=0.012), exposure to passive smoking (MC=0.46, p=0.034) and mother’s weight gain during pregnancy (MC=0.23, p=0.019). Conclusions The study suggests that environment influences methylation patterns in maternal blood, and then the maternal patterns influence the methylation status and levels of folate and vitamin B12 in cord blood.

show abstract

Section: Discussionmentioning

confidence: 74%

Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood

Liu

et al. 2011

Eur J Clin Nutr

View full text Add to dashboard Cite

show abstract

“…Impact of textureLanerolle et al (2013) 11

Sri Lanka

High-school children aged 10–16 y

Stand-alone and combined PSEEs (small and life-size photos, life-size line diagrams, and household spoons in 3 sizes). Portion sizes based on government 67 and other schemes 70 , 71 , 56 Validation vs actual weight (as assessed by 80 teenagers) for 4 PSEAs. Portion sizes derived from consumption studies.…”

Section: Resultsmentioning

confidence: 99%

Dietary assessment in minority ethnic groups: a systematic review of instruments for portion-size estimation in the United Kingdom

et al. 2017

View full text Add to dashboard Cite

Context: Dietary assessment in minority ethnic groups is critical for surveillance programs and for implementing effective interventions. A major challenge is the accurate estimation of portion sizes for traditional foods and dishes. Objective: The aim of this systematic review was to assess records published up to 2014 describing a portion-size estimation element (PSEE) applicable to the dietary assessment of UK-residing ethnic minorities. Data sources, selection, and extraction: Electronic databases, internet sites, and theses repositories were searched, generating 5683 titles, from which 57 eligible full-text records were reviewed. Data analysis: Forty-two publications about minority ethnic groups (n = 20) or autochthonous populations (n = 22) were included. The most common PSEEs (47%) were combination tools (eg, food models and portion-size lists), followed by portion-size lists in questionnaires/guides (19%) and image-based and volumetric tools (17% each). Only 17% of PSEEs had been validated against weighed data. Conclusions: When developing ethnic-specific dietary assessment tools, it is important to consider customary portion sizes by sex and age, traditional household utensil usage, and population literacy levels. Combining multiple PSEEs may increase accuracy, but such methods require validation.

show abstract

“…However, the mean serum folate of Iranian women was close to the mean se- [34] . The mean serum homocysteine concentration of the Iranian women (12.6 mol/l) was much higher compared to British, Gambian [32] , French, Italian and Mexican women [31] ; it was also higher than in women from Sri Lanka [30] , but lower than in West African women [31] ( table 4 ).…”

Section: Discussionmentioning

confidence: 99%

“…The mean serum folate of the women in our study (13.6 nmol/l) was higher than that of women in Bangladesh [29] , Sri Lanka [30] , France and Italy [31] , but lower than the mean serum folate of women in the UK [32] , Mexico [31] , Croatia [33] and Gambia [32] . However, the mean serum folate of Iranian women was close to the mean se- [34] .…”

Section: Discussionmentioning

confidence: 99%

Folate, Vitamin B<sub>12</sub> and Homocysteine Status in Women of Childbearing Age: Baseline Data of Folic Acid Wheat Flour Fortification in Iran

et al. 2008

View full text Add to dashboard Cite

Background: Folic acid fortification implemented mandatorily in many countries has been associated with significant increase in blood folate concentrations and reduction in the prevalence of neural tube defects. However, there are controversial findings on the probability of vitamin B₁₂ deficiency being masked in the population after folic acid fortification. Baseline data on folate and vitamin B₁₂ status are necessary before mandatory flour fortification is implemented. Objectives: To assess dietary intake of folate and vitamin B₁₂ and to determine blood concentrations of folate, vitamin B₁₂ and homocysteine in women of childbearing age as baseline data regarding folic acid fortification in Iran. Methods: A descriptive cross-sectional survey was performed with 579 healthy women as a representative sample of the Golestan province. Fasting blood samples were taken and dietary (24-hour recall), health and sociodemographic data were collected with an interview. Serum concentrations of folate and vitamin B₁₂ were measured with radioimmunoassay, and plasma homocysteine concentrations were assessed by high-performance liquid chromatography with fluorescence detection. Results: Mean serum concentrations of folate and vitamin B₁₂ were 13.6 nmol/l (95% CI 12.8–14.4) and 194.4 pmol/l (95% CI 183.8–205.0), respectively. Inadequate serum folate levels were present in 14.3% of the women and 22.7% had serum vitamin B₁₂ levels below normal. Mean plasma homocysteine concentration was 12.6 µmol/l (95% CI 12.1–13.2) and hyperhomocysteinemia was observed in 38.3% of the women. Mean daily intake of folate and vitamin B₁₂ was 198.3 µg (95% CI 185.4–211.3) and 2.6 µg (95% CI 1.9–3.2), respectively. Folate intake from food was positively correlated with serum folate concentrations (r = 0.084, p < 0.05) and inversely correlated with plasma homocysteine concentrations (r = –0.115, p < 0.01). Conclusions: An insufficient vitamin B₁₂ as well as folate status is present in Iranian women of childbearing age. The final evaluation will be carried out 18 months after flour fortification and the results will be compared with baseline data obtained from the present study in order to show the efficacy and safety of folic acid fortification in Iran.

show abstract

Low folic acid status and its association with anaemia in urban adolescent girls and women of childbearing age in Sri Lanka

Cited by 45 publications

References 21 publications

Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood

Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood

Dietary assessment in minority ethnic groups: a systematic review of instruments for portion-size estimation in the United Kingdom

Folate, Vitamin B<sub>12</sub> and Homocysteine Status in Women of Childbearing Age: Baseline Data of Folic Acid Wheat Flour Fortification in Iran

Contact Info

Product

Resources

About