Low folate in seminal plasma is associated with increased sperm DNA damage

Boxmeer, Jolanda C.; Smit, Marij; Utomo, Elaine; Romijn, Johannes C.; Eijkemans, Marinus J.C.; Lindemans, Jan; Laven, Joop S.E.; Macklon, Nick S.; Steegers, Eric A.P.; Steegers‐Theunissen, R.P.M.

doi:10.1016/j.fertnstert.2008.06.010

Cited by 124 publications

(118 citation statements)

References 28 publications

(33 reference statements)

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“…A study conducted by Wallock and co-authors found a significant association between low seminal plasma folate concentrations, with low sperm density and total sperm count, both in male smokers and nonsmokers, leading to a significant loss of fertility (Wallock et al, 2001). A later study conducted by Boxmeer and co-authors confirmed the previous findings and reported an increase in sperm DNA damage in men (Boxmeer et al, 2009). Folate deficiency was therefore associated with indicators of reduced male fertility.…”

Section: Folate Deficiency In Rodentssupporting

confidence: 71%

The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice

Voutounou

Glen

Dubrova

2012

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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Section: Folate Deficiency In Rodentssupporting

confidence: 71%

The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice

Voutounou

Glen

Dubrova

2012

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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“…Folate has antioxidant properties that counteract reactive oxygen species (ROS) [34]. It has been reported that low concentrations of folate in seminal plasma is associated with increased sperm DNA damage [9]. Low seminal plasma folate concentrations correlated significantly with low sperm density and total sperm count in male smokers and nonsmokers [35].…”

Section: Discussionmentioning

confidence: 99%

“…Boxmeer et al have demonstrated that low concentrations of folate in seminal plasma is associated with increased levels of sperm DNA damage in fertile men, and suggested that low folate in the microenvironment of spermatozoa may have adverse effects on sperm DNA stability [9]. The human MTHFR gene is composed of 11 exons and located on the short (p) arm of chromosome one (1p36.3) [10], catalyzing the reduction of methylene tetrahydrofolate (5,10-methyl THF) to methyl tetrahydrofolate (5-methyl THF) [11].…”

Section: Introductionmentioning

confidence: 99%

Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population

et al. 2015

J Assist Reprod Genet

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Purpose This study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folaterelated enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population. Methods The polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males. Results We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility. Conclusions There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.

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“…Varicocelectomy, in the other hand, may decrease seminal oxidative stress, increase seminal concentrations of antioxidants and also improve sperm quality [39]. In recent years, interest has increased regarding the role of antioxidants and B-vitamins as modulators of fertility [40][41][42][43]. The antioxidants a-tocopherol (Vitamin E), ascorbic acid (Vitamin C) and the retinoids (Vitamin A) are potent scavengers of ROS.…”

Section: What Is New In Treament Antioxidant Therapymentioning

confidence: 99%

“…Wong et al (2002) demonstrated, in a randomized and placebo-controlled trial, that a 6-month administration of folic acid (5mg) and zinc phosphate (66mg) increased sperm counts in subfertile men [40]. Boxmeer et al (2009) reported for the first time that low folate concentrations in the seminal plasma are associated with higher susceptibility of sperm DNA damage [41]. This novel finding is in line with the role of folate in both DNA synthesis and DNA and protein methylation processes.…”

Section: What Is New In Treament Antioxidant Therapymentioning

confidence: 99%

What is New in the Clinical Assessment and Treatment of the Infertile Male

Esteves¹

2011

TORSJ

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Male infertility is a fast-evolving area. Recently published evidence has challenged several established concepts and added to the knowledge in the field. Traditionally, the clinical assessment of the subfertile male includes a history and physical examination, hormonal evaluation and semen analyses. Regarding the latter, the World Health Organization has established new reference values that in general include lower limits than those of previous editions. Specialized sperm function assays, such as sperm DNA integrity and measurements of oxidative stress, are now clinically available and may be integrated to the conventional semen analysis to provide a more comprehensive evaluation of a man's fertility status. Also, molecular biology genetic testing involving the Y-chromosome can correctly identify oligozoospermic and azoospermic men misdiagnosed as having idiopathic infertility and be of prognostic value for sperm retrieval in non-obstructive azoospermia. In the field of treatment, emerging evidence suggests that antioxidant therapy along with life-style modifications improve the male reproductive health. Microsurgery has increased the success rates for both varicocele treatment and sperm retrieval for assisted conception. Microsurgical treatment of clinical varicoceles may optimize reproductive outcome of couples undergoing intracytoplasmic sperm injection or microsurgical testicular sperm extraction. Men with non-obstructive azoospermia, elevated follicle-stimulating hormone levels and small testes may no longer be considered sterile. Modern retrieval techniques are used to collect testicular sperm that can be used to produce a healthy biological offspring via assisted conception. This article reviews what is new in the clinical assessment and treatment of the infertile male, including the implications of this increased knowledge in the management of the infertile couple and assisted reproduction technology outcomes.

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Low folate in seminal plasma is associated with increased sperm DNA damage

Cited by 124 publications

References 28 publications

The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice

The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice

Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population

What is New in the Clinical Assessment and Treatment of the Infertile Male

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