LOW FLUENCE Q-SWITCHED Nd: YAG LASER TONING AND Q-SWITCHED RUBY LASER IN THE TREATMENT OF MELASMA:A COMPARATIVE SPLIT-FACE ULTRASTRUCTURAL STUDY

Omi, Tokuya; Yamashita, Rie; Kawana, Seiji; Satō, Shigeru; Naito, Zenya

doi:10.5978/islsm.12-or-03

Cited by 32 publications

(15 citation statements)

References 21 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prior studies have demonstrated that there is considerable variation in the laser parameters applied in the treatment of pigmentary diseases (usually between two and eight passes) [18][19][20]27]. Our results demonstrate that there is a positive correlation between the number of laser passes and pigmentation improvement.…”

Section: Discussionsupporting

confidence: 66%

See 1 more Smart Citation

Melanogenesis inhibition in mice using a low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser: a pilot study

et al. 2017

View full text Add to dashboard Cite

A low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser, or laser toning, has yielded favorable outcomes in various benign pigmented disorders. However, the exact mechanism of action of laser toning has not been fully elucidated. We sought to determine the inhibitory effect of laser toning on melanogenesis and to assess how laser passes influence the outcomes. To produce perceptible pigmentation, nine HRM-2 melanin-possessing hairless mice were treated with ultraviolet (UV) B radiation on the dorsal skin. This was followed by zero, two, four, or six passes of laser toning twice in 2 weeks on each designated quadrant. The spectrophotometric values and pigmentation-related protein expressions were measured. Pigment changes were found in the mice skin using the Fontana-Masson stain for histopathological analysis. Four- and six-pass laser toning significantly improved the lightness compared to that in the unirradiated control (p < 0.002). The Fontana-Masson stain showed that melanin was considerably decreased in laser-irradiated skin. As the number of laser passes increased, the expression of tyrosinase decreased (p < 0.008). The following parameters also decreased in proportion to the number of laser passes: MITF, TRP-1, TRP-2, p-ERK, and p-Akt. In contrast, TGF-β increased in proportion to the number of laser passes. However, the changes in these six proteins were not statistically significant. Our study demonstrates that laser toning improves skin pigmentation with increased number of passes in a dose-dependent manner. This effect is mediated by tyrosinase inhibition.

show abstract

Section: Discussionsupporting

confidence: 66%

“…Laser toning is widely applied in the treatment of melasma [19], café-au-lait macules [20], and photodamaged skin [21] and provides versatility in the armamentarium of pigmentary disease. Despite this, however, only a few studies have addressed the actual mechanism of laser action.…”

Section: Introductionmentioning

confidence: 99%

Melanogenesis inhibition in mice using a low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser: a pilot study

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Recently, an irradiation procedure known as laser toning has been applied to alleviate facial melasma of women for cosmetic purposes [16,17]. Given that our previous experience using laser toning with an Nd:YAG laser for melasma brought about fairly good results, we applied this procedure to CALMs and small pigmented freckles on seven NF1 patients in combination with topical tacalcitol application.…”

Section: Resultsmentioning

confidence: 99%

Vitamin D3 and Neurofibromatosis Type 1

Nakayama¹

2017

A Critical Evaluation of Vitamin D - Clinical Overview

View full text Add to dashboard Cite

Vitamin D3 (VD3) and its analogs have been shown to inhibit growth of various cell types found in neurofibromas and pigmented lesions of patients with neurofibromatosis type 1 (NF1). Excimer light irradiation at 150-300 mJ/cm 2 in combination with VD3 efficiently inhibited growth of cultured fibroblasts, mast cells, Schwann cells, and melanocytes. Long-term whole body irradiation with narrowband ultraviolet B (UVB) in patients with NF1 significantly increased serum levels of VD3, which was accompanied by a brightening of generalized skin hyperpigmentation. Irradiation with either laser or intense pulsed-radio frequency in combination with topical application of VD3 analogs yielded moderate to fair improvement of café-au-lait macules, small pigmented spots, and skin-fold freckling in NF1 patients. Thus, topical or systemic application of VD3 or one of its analogs may provide beneficial effects to treat skin lesions for patients with NF1.

show abstract

“…4,5 And furthermore, the 1,064 nm Nd:YAG laser toning is proposed to cause the fragmentation of melanin granules and reduce the number of melanosomes without cellular destruction with a sub-photo-thermolytic fluence. 6 Recently, it has produced favorable outcomes, showing 50% to 74% response rates in many benign pigmented disorders, such as melasma and nevus of Ota. 7 Also, case report on CALM treatment has appeared.…”

Section: A B Cmentioning

confidence: 99%

Combination Treatments of 755 nm Alexandrite Laser with 1,064 nm Nd:YAG Laser Toning for Café Au Lait Macule

et al. 2015

View full text Add to dashboard Cite

LOW FLUENCE Q-SWITCHED Nd: YAG LASER TONING AND Q-SWITCHED RUBY LASER IN THE TREATMENT OF MELASMA:A COMPARATIVE SPLIT-FACE ULTRASTRUCTURAL STUDY

Cited by 32 publications

References 21 publications

Melanogenesis inhibition in mice using a low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser: a pilot study

Melanogenesis inhibition in mice using a low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser: a pilot study

Vitamin D3 and Neurofibromatosis Type 1

Combination Treatments of 755 nm Alexandrite Laser with 1,064 nm Nd:YAG Laser Toning for Café Au Lait Macule

Contact Info

Product

Resources

About