Low-Flow Mediated Constriction is Endothelium-Dependent

Dawson, Ellen A.; Alkarmi, Amr; Thijssen, Dick H. J.; Rathore, Sudhir; Marsman, Diane; Cable, N. Timothy; Wright, Dominic; Green, Daniel

doi:10.1161/circinterventions.112.971556

Cited by 46 publications

(31 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[15][16][17]19 The retinal peripapillary region is a designated low-flow area, and it was found that in an artificial low-flow area, flow-mediated constriction was diminished after endothelial denudation through catheterization, suggesting that this is an endothelium-dependent reaction. 20 In preeclampsia RFR is impaired. Therefore, we suggest that reduced AA and MAC in preeclampsia may indicate preaged and stiffened microvessels, which result from EDF and remodeling.…”

Section: Discussionmentioning

confidence: 99%

Altered Retinal Flicker Response Indicates Microvascular Dysfunction in Women With Preeclampsia

Brückmann¹,

Seeliger²,

Lehmann³

et al. 2015

Hypertension

View full text Add to dashboard Cite

Abstract-Flicker-induced dilatation is reduced in patients with cardiovascular risk, and the following arteriolar constriction is reduced with aging, leading to a reduced arteriolar amplitude and, thereby, indicating microvascular endothelial dysfunction. As endothelial dysfunction is associated with preeclampsia, we assessed retinal flicker response during pregnancy and postpartum. Between 2006 and 2013, women were recruited from University Hospital Jena and Prenatal Diagnostic Center Erfurt, Germany, of which 34 women with preeclampsia, 45 women with normal pregnancy, and 22 nonpregnant controls were included in the study. Women with normal pregnancy were matched for age, nulliparity, smoking, previous gestational hypertensive disorders, and family history of cardiovascular disease. Nonpregnant women were age-matched, nulliparous, nonsmoking, without family history of cardiovascular disease. Retinal vessel measurement using Dynamic Vessel Analyzer consisted of 50-seconds baseline acquisition, followed by three 20-second flicker and 80-second relaxation periods. Arteriolar constriction and arteriolar amplitude were reduced during pregnancy (P=0.001 and P=0.008) and postpartum (P=0.018 and P=0.034) in women with preeclampsia, adjusted for age, body mass index, mean arterial pressure, baseline diameter, and family history of cardiovascular disease. Flicker-induced dilatation was unchanged within the groups and throughout the study period. The unchanged flicker-induced dilatation may support a preserved autoregulatory competence of the microvasculature, and the diminished arteriolar amplitude, mainly because of the absence of the arteriolar constriction, indicates a commenced retinal microvascular dysfunction in women with preeclampsia during pregnancy and postpartum. Mechanisms responsible for altered retinal flicker response in preeclampsia need to be clarified in further studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Altered Retinal Flicker Response Indicates Microvascular Dysfunction in Women With Preeclampsia

Brückmann¹,

Seeliger²,

Lehmann³

et al. 2015

Hypertension

View full text Add to dashboard Cite

show abstract

“…Some authors have described radial artery vasoconstriction during low flow and suggested that this is an additional marker of endothelial function [11][12][13][14][15][16] . However, the low-flowmediated vasoconstriction (L-FMC) seems to be specific to the radial artery because it has not been consistently described for the brachial artery.…”

Section: Ultrasound Study Proceduresmentioning

confidence: 99%

Brachial Low-Flow-Mediated Constriction is Associated with Delayed Brachial Flow-Mediated Dilation

Irace

Tripolino

Scavelli

et al. 2016

JAT

View full text Add to dashboard Cite

Aim: Flow-mediated vasodilation (FMD) of the brachial artery measures the ability of the artery to dilate after a forearm ischemia lasting for 5 min. During ischemia, and therefore in conditions of low flow, constriction of the brachial artery (L-FMC) has sometimes been reported. The meaning of L-FMC is still unclear. The aims of our study were to establish the prevalence of subjects with L-FMC, to determine whether the magnitude of L-FMC correlates with magnitude of FMD, and to determine whether L-FMC can be used to predict FMD timing. Methods: A total of 179 outpatients were studied, and the brachial artery diameter was measured every minute during the 5 min forearm ischemia. Subjects who had at least one measurement showing a constriction of 1% during ischemia were defined as constrictors. FMD was evaluated at 50 s, 2 min, and 3 min after cuff release. On the basis of time, the subjects in whom maximal dilation had occurred were divided into Early, Late, or No dilators. Conclusions:The present study reveals that almost 40% of the subjects had brachial artery L-FMC and a more pronounced constriction during ischemia correlated with a lower dilation after ischemia. Finally, the prevalence of subjects showing L-FMC was significantly higher among subjects with delayed or no vasodilation, suggesting that L-FMC may be a marker of endothelial dysfunction.

show abstract

“…Moreover, we demonstrate for the first time that exercise training has beneficial impacts on radial artery vasodilator and constrictor function. 10 …”

Section: Low-flow Mediated Constriction Is Endothelium-dependent: Effmentioning

confidence: 99%

Circulation Editors’ Picks

2013

Circulation

View full text Add to dashboard Cite

Low-Flow Mediated Constriction is Endothelium-Dependent

Cited by 46 publications

References 23 publications

Altered Retinal Flicker Response Indicates Microvascular Dysfunction in Women With Preeclampsia

Altered Retinal Flicker Response Indicates Microvascular Dysfunction in Women With Preeclampsia

Brachial Low-Flow-Mediated Constriction is Associated with Delayed Brachial Flow-Mediated Dilation

Circulation Editors’ Picks

Contact Info

Product

Resources

About