Low field CIDNP of amino acids and proteins: characterization of transient radicals and NMR sensitivity enhancement

Lyon, Charles E.; Lopez, Jakob J.; Cho, Byung-Mun; Hore, P. J.

doi:10.1080/00268970110113988

Cited by 34 publications

(45 citation statements)

References 33 publications

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“…More recent advances have allowed the monitoring of protein folding in real time, using stopped-flow techniques [58], the use of heteronuclear 2D CIDNP to study proteins in non-native states and the optimisation of CIDNP magnitudes using the bore of the superconducting magnet in an NMR spectrometer [59]. CIDNP has proved itself a powerful tool for scientists interested in the structure of biopolymers.…”

Section: ·1·1 Biological Applications Of Cidnpmentioning

confidence: 99%

Radical Pairs in Solution

Woodward

2002

Progress in Reaction Kinetics and Mechanism

152

101

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Radical pairs (RPs) are important reaction intermediates generated whenever two radicals encounter one another, a bond is cleaved homolytically or electron transfer between non-radical species takes place. The concept of a radical pair as a reaction intermediate is introduced and developed through simple pictorial analogies, indicating how RP behaviour is governed by interplay of spin and spatial motion. Such analogies are then extended to describe the experimental consequences of RPs in magnetic resonance and magnetochemistry experiments, including reference to the relevance of RPs in biological systems. Finally experimental techniques by which RPs can be observed directly are introduced and described in the context of the developed models.

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Section: ·1·1 Biological Applications Of Cidnpmentioning

confidence: 99%

Radical Pairs in Solution

Woodward

2002

Progress in Reaction Kinetics and Mechanism

152

101

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“…The method can also be used to extract HFCs and g-factor differences in radical pairs [33,60,67]. Furthermore, it is possible to affect the CIDNP level by inducing electron spin transitions in the radicals, which is the essence of stimulated nuclear polarization, SNP [68,69].…”

Section: B Cidnp Field Dependencementioning

confidence: 99%

“…Typically the sample is moved through along the warm bore inhomogeneous field of the NMR spectrometer magnet through its fringe field, which is often in superposition with the field of an auxiliary magnetic system. The sample is shuttled manually (in the simplest case, as it was done in the early days of field-cycling NMR) or by using pneumatic systems [26][27][28][29][30][31], flow systems [32][33][34] and programmable motors, shuttling either the sample [35][36][37] of the whole NMR probe [38,39]. Recently a review on field-cycling NMR methods and their applications to spin relaxation measurements has been published by Fujara et al [25].…”

Section: Introductionmentioning

confidence: 99%

A fast field-cycling device for high-resolution NMR: Design and application to spin relaxation and hyperpolarization experiments

Kiryutin

Pravdivtsev

Ivanov

et al. 2016

Journal of Magnetic Resonance

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“…In particular, it is often the case that hyperpolarization is maximal at low magnetic fields, whereas modern highresolution NMR spectrometers are operating at high fields. For this reason, various field-cycling NMR methods [30][31][32][33][34][35] have been developed to tackle this problem and also to study fielddependent relaxation phenomena [36][37][38] in particular, because of their importance for the life-time of hyperpolarization. In this context, it is relevant for optimizing the performance of hyperpolarization techniques to understand on a quantitative level how the spin-spin interactions affect the evolution of multispin systems during the field variation.…”

Section: Introductionmentioning

confidence: 99%

Coherent transfer of nuclear spin polarization in field-cycling NMR experiments

Pravdivtsev

Yurkovskaya

Vieth

et al. 2013

The Journal of Chemical Physics

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Coherent polarization transfer effects in a coupled spin network have been studied over a wide field range. The transfer mechanism is based on exciting zero-quantum coherences between the nuclear spin states by means of non-adiabatic field jump from high to low magnetic field. Subsequent evolution of these coherences enables conversion of spin order in the system, which is monitored after field jump back to high field. Such processes are most efficient when the spin system passes through an avoided level crossing during the field variation. The polarization transfer effects have been demonstrated for N-acetyl histidine, which has five scalar coupled protons; the initial spin order has been prepared by applying RF-pulses at high magnetic field. The observed oscillatory transfer kinetics is taken as a clear indication of a coherent mechanism; level crossing effects have also been demonstrated. The experimental data are in very good agreement with the theoretical model of coherent polarization transfer. The method suggested is also valid for other types of initial polarization in the spin system, most notably, for spin hyperpolarization.

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Low field CIDNP of amino acids and proteins: characterization of transient radicals and NMR sensitivity enhancement

Cited by 34 publications

References 33 publications

Radical Pairs in Solution

Radical Pairs in Solution

A fast field-cycling device for high-resolution NMR: Design and application to spin relaxation and hyperpolarization experiments

Coherent transfer of nuclear spin polarization in field-cycling NMR experiments

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