Low Fecal Calprotectin Correlates with Histological Remission and Mucosal Healing in Ulcerative Colitis and Colonic Crohnʼs Disease

Zittan, Eran; Kelly, Orlaith; Kirsch, Richard; Milgrom, Raquel; Burns, Jane S.; Nguyen, Geoffrey C.; Croitoru, Ken; Assche, Gert Van; Silverberg, Mark S.; Steinhart, A. Hillary

doi:10.1097/mib.0000000000000652

Cited by 138 publications

(61 citation statements)

References 42 publications

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“…Several groups have shown that FC levels correlate with endoscopic disease activity in CD patients 5,29,30 , but few studies have assessed the correlation between FC levels and mucosal lesions in the deep small intestine in CD. In the present study, a moderate agreement was found between FC levels and small bowel CD.…”

Section: Discussionmentioning

confidence: 99%

Levels of Faecal Calprotectin and Magnetic Resonance Enterocolonography Correlate with Severity of Small Bowel Crohn’s Disease: A Retrospective Cohort Study

Cheng

Chen

et al. 2017

Sci Rep

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Few studies have evaluated the usefulness of fecal calprotectin (FC) or magnetic resonance enterography (MRE) in diagnosing active Crohn’s disease (CD) of the small bowel. In the study, we investigated the reliability of FC and MRE in assessing the activity of ileal CD and further explored the relationship between levels of FC and MRE scores. A total of 221 patients were diagnosed with ileal or ileo-colitis CD in our department between July 2012 and October 2016. The global magnetic resonance index of activity (MaRIA) correlated with the simple endoscopic score for CD (SES-CD) (r = 0.527, P = 0.005). When analysed segment-by-segment, a significant correlation was still observed (r = 0.590, P < 0.001). The SES-CD correlated closest with FC (r = 0.503), followed by CRP (r = 0.461), ESR (0.377) and the CDAI (r = 0.320). In receiver operating characteristic (ROC) analyses, the FC cut-off value of mucosal healing was 213.1 μg/g, with 76.1% sensitivity and 66.7% specificity. As for MaRIA, a cut-off value of 6.8 for each segment provided a sensitivity of 100% and a specificity of 79.2%. No agreement between MaRIA and FC levels was found. In conclusion, a combination of FC levels and MaRIA could be effective in monitoring mucosal activity in patients with small bowel CD.

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Section: Discussionmentioning

confidence: 99%

Levels of Faecal Calprotectin and Magnetic Resonance Enterocolonography Correlate with Severity of Small Bowel Crohn’s Disease: A Retrospective Cohort Study

Cheng

Chen

et al. 2017

Sci Rep

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“…Zittan et al . [ 20 ] also demonstrated that the FC test highly correlated with clinical symptoms in UC but less so in colonic CD. However, Tursi et al .…”

Section: Discussionmentioning

confidence: 99%

“…[ 31 34 ] Therefore, monitoring FC may decrease the need for invasive procedures to distinguish patients with quiescent disease who develop functional symptoms from those with active inflammation and who may benefit from escalation in therapy. [ 20 ] FC is a reliable, simple, inexpensive, and safe test that correlates closely with endoscopic findings in UC. [ 35 36 ] It provides more objective results than fecal microscopy and bypasses the difficulty of identifying stool leukocytes.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive biomarkers as surrogate predictors of clinical and endoscopic remission after infliximab induction in patients with refractory ulcerative colitis

Hassan

Ramadan

Ismael

et al. 2017

Saudi J Gastroenterol

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“…In ulcerative colitis, a fecal calprotectin > 250 μg/g indicated active disease (Mayo subscore > 0) with a sensitivity of 71.0% and a specificity of 100% [3] . Low fecal calprotectin levels correlated well with histological remission (Geboes score < 3.1) and mucosal healing [19] . In addition, fecal calprotectin measurement can be used to identify patients with increased risk of relapse after 6 and 12 months and to predict histological healing [20] .…”

Section: Discussionmentioning

confidence: 84%

Is Fecal Calprotectin or Fecal Immunochemical Measurement for Occult Blood a good Marker for Mucosal Healing in Ulcerative Colitis?

Otsuka¹,

Someya²,

Asakura³

et al. 2019

Journal of Gastroenterology and Hepatology Research

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AIM: Mucosal healing is an important therapeutic goal for IBD treatment. This study was performed to evaluate which methods of fecal calprotectin or fecal immunochemical test would be a good biomarker for mucosal healing compared with colonoscopic and /or pathological findings. METHODS: Ulcerative colitis patients in remission, mild and moderate activities took an examination of blood biomarkers and colonoscopy, and their fecal specimens were tested on the day before bowel preparation for colonoscopy. RESULTS: Although blood markers were almost within normal limits, fecal calprotectin and immunochemical test for occult blood were useful biomarkers for judging mucosal healing of ulcerative colitis. Fecal calprotectin and immunochemical test were well correlated with the ulcerative colitis endoscopic index of severity and sum of Mayo subscore at 5 segments of the colonorectum. CONCLUSION: Fecal immunochemical test is useful for estimating mucosal healing as same as fecal calprotectin and low in cost.

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Low Fecal Calprotectin Correlates with Histological Remission and Mucosal Healing in Ulcerative Colitis and Colonic Crohnʼs Disease

Abstract: Low FC correlates well with histological remission and mucosal healing in colonic inflammatory bowel disease and is thus a clinically useful surrogate for inflammatory activity.

Cited by 138 publications

References 42 publications

Levels of Faecal Calprotectin and Magnetic Resonance Enterocolonography Correlate with Severity of Small Bowel Crohn’s Disease: A Retrospective Cohort Study

Levels of Faecal Calprotectin and Magnetic Resonance Enterocolonography Correlate with Severity of Small Bowel Crohn’s Disease: A Retrospective Cohort Study

Noninvasive biomarkers as surrogate predictors of clinical and endoscopic remission after infliximab induction in patients with refractory ulcerative colitis

Is Fecal Calprotectin or Fecal Immunochemical Measurement for Occult Blood a good Marker for Mucosal Healing in Ulcerative Colitis?

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