Low-Fat, High-Fiber Diet Reduces Markers of Inflammation and Dysbiosis and Improves Quality of Life in Patients With Ulcerative Colitis

Fritsch, Júlia; Garces, Luis C.; Quintero, Maria A.; Pignac-Kobinger, Judith; Santander, Ana M.; Fernández, Irina; Ban, Yuguang; Kwon, Deukwoo; Phillips, Matthew C.; Knight, Karina; Mao, Qingqing; Santaolalla, Rebeca; Chen, Xi S.; Maruthamuthu, Mukil; Solis, Norma; Damas, Oriana M.; Kerman, David H.; Deshpande, Amar R.; Lewis, John E.; Chen, Chi; Abreu, María T.

doi:10.1016/j.cgh.2020.05.026

Cited by 164 publications

(162 citation statements)

References 25 publications

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“…A high fat diet should be also avoided by IBD patients due to the fact that it could lead to an accumulation of bile acids (like deoxycholic acid) that could inhibit Bacteroidetes and Firmicutes phyla growth and lead to dysbiosis [54]. A recent cross-over study [121] demonstrated that a low-fat diet reduces markers of inflammation and dysbiosis and improves quality of life in patients with ulcerative colitis. In particular, it has been shown that low-fat diets increase the proportion of Bacteroidetes in the microbiota from 14.6% to 24.02% (p = 0.015) and decrease that of Actinobacteria from 13.69% to 7.82% (p = 0.017).…”

Section: Animal Fatsmentioning

confidence: 99%

Diet and Nutrients in Gastrointestinal Chronic Diseases

et al. 2020

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Diet and nutrition are known to play key roles in many chronic gastrointestinal diseases, regarding both pathogenesis and therapeutic possibilities. A strong correlation between symptomatology, disease activity and eating habits has been observed in many common diseases, both organic and functional, such as inflammatory bowel disease and irritable bowel syndrome. New different dietary approaches have been evaluated in order improve patients’ symptoms, modulating the type of sugars ingested, the daily amount of fats or the kind of metabolites produced in gut. Even if many clinical studies have been conducted to fully understand the impact of nutrition on the progression of disease, more studies are needed to test the most promising approaches for different diseases, in order to define useful guidelines for patients.

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Section: Animal Fatsmentioning

confidence: 99%

Diet and Nutrients in Gastrointestinal Chronic Diseases

et al. 2020

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“…The key nutrient difference between these diets was the lower fat content in the LFD; however, the LFD diet was also significantly higher in fiber and lower in sugar than the iSAD. Both diets led to improved QoL, but the LFD also led to a significant reduction in serum amyloid A and a trend towards a decrease in C-reactive protein (CRP) that was not observed in the iSAD group [ 68 ]. This suggests that the combination of low fat and high fiber provides additional clinical benefits beyond only increasing fruit and vegetable intakes as recommended in the iSAD group.…”

Section: Utilizing Fiber As An Induction or Maintenance Therapy Inmentioning

confidence: 99%

“…This suggests that the combination of low fat and high fiber provides additional clinical benefits beyond only increasing fruit and vegetable intakes as recommended in the iSAD group. In all three food-based fiber intervention studies there were high rates of remission maintenance as well as improved clinical outcomes and symptomology [ 66 , 67 , 68 ]. Additionally, the diets were all well tolerated.…”

Section: Utilizing Fiber As An Induction or Maintenance Therapy Inmentioning

confidence: 99%

“…Interestingly, in this study, butyrate was shown to be inversely associated with Mayo scores, a measure of disease activity, in the high-dose group, providing some evidence to suggest that fiber-dependent butyrate production may help treat active disease at least in UC patients [ 59 ]. Additionally, a LFD has been shown to alter other microbial metabolites outside of butyrate, with this fiber intervention leading to significant increases in acetate as well as tryptophan [ 68 ] ( Figure 1 ).…”

Section: The Impact Fiber Has On the Gut Microbiome In Pediatric Imentioning

confidence: 99%

“…The most consistent fiber-specific alteration in gut microbiota composition has been the expansion of bifidobacteria [ 56 , 57 , 59 ]. Other bacterial taxa that have been shown to be modulated by fiber in IBD patients include Faecalibacterium prausnitzii , Bacteroidetes (including Bacteroides ), Actinobacteria, Ruminococcus gnavus, Parabacteriodes and Lachnospiraceae [ 57 , 59 , 68 ] ( Figure 1 ). One study also showed that a high-fiber diet led to significant shifts in beta diversity from baseline, suggesting that some fiber interventions can have an impact on the entire bacterial community, not just individual bacterial taxa [ 59 ].…”

Section: The Impact Fiber Has On the Gut Microbiome In Pediatric Imentioning

confidence: 99%

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Fiber and Prebiotic Interventions in Pediatric Inflammatory Bowel Disease: What Role Does the Gut Microbiome Play?

et al. 2020

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The etiology of inflammatory bowel disease (IBD) is complex but is thought to be linked to an intricate interaction between the host’s immune system, resident gut microbiome and environment, i.e., diet. One dietary component that has a major impact on IBD risk and disease management is fiber. Fiber intakes in pediatric IBD patients are suboptimal and often lower than in children without IBD. Fiber also has a significant impact on beneficially shaping gut microbiota composition and functional capacity. The impact is likely to be particularly important in IBD patients, where various studies have demonstrated that an imbalance in the gut microbiome, referred to as dysbiosis, occurs. Microbiome-targeted therapeutics, such as fiber and prebiotics, have the potential to restore the balance in the gut microbiome and enhance host gut health and clinical outcomes. Indeed, studies in adult IBD patients demonstrate that fiber and prebiotics positively alter the microbiome and improve disease course. To date, no studies have been conducted to evaluate the therapeutic potential of fiber and prebiotics in pediatric IBD patients. Consequently, pediatric IBD specific studies that focus on the benefits of fiber and prebiotics on gut microbiome composition and functional capacity and disease outcomes are required.

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LncRNA LINK‐A Remodels Tissue Inflammatory Microenvironments to Promote Obesity

Chen,

Wang

et al. 2023

Advanced Science

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High‐fat diet (HFD)‐induced obesity is a crucial risk factor for metabolic syndrome, mainly due to adipose tissue dysfunctions associated with it. However, the underlying mechanism remains unclear. This study has used genetic screening to identify an obesity‐associated human lncRNA LINK‐A as a critical molecule bridging the metabolic microenvironment and energy expenditure in vivo by establishing the HFD‐induced obesity knock‐in (KI) mouse model. Mechanistically, HFD LINK‐A KI mice induce the infiltration of inflammatory factors, including IL‐1β and CXCL16, through the LINK‐A/HB‐EGF/HIF1α feedback loop axis in a self‐amplified manner, thereby promoting the adipose tissue microenvironment remodeling and adaptive thermogenesis disorder, ultimately leading to obesity and insulin resistance. Notably, LINK‐A expression is positively correlated with inflammatory factor expression in individuals who are overweight. Of note, targeting LINK‐A via nucleic acid drug antisense oligonucleotides (ASO) attenuate HFD‐induced obesity and metabolic syndrome, pointing out LINK‐A as a valuable and effective therapeutic target for treating HFD‐induced obesity. Briefly, the results reveale the roles of lncRNAs (such as LINK‐A) in remodeling tissue inflammatory microenvironments to promote HFD‐induced obesity.

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Low-Fat, High-Fiber Diet Reduces Markers of Inflammation and Dysbiosis and Improves Quality of Life in Patients With Ulcerative Colitis

Cited by 164 publications

References 25 publications

Diet and Nutrients in Gastrointestinal Chronic Diseases

Diet and Nutrients in Gastrointestinal Chronic Diseases

Fiber and Prebiotic Interventions in Pediatric Inflammatory Bowel Disease: What Role Does the Gut Microbiome Play?

LncRNA LINK‐A Remodels Tissue Inflammatory Microenvironments to Promote Obesity

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