Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients

Krueger, Katharina; Koch, Kathrin; Jühling, Anja; Tepel, Martín; Scholze, Alexandra

doi:10.1016/j.clinbiochem.2009.08.005

Cited by 25 publications

(20 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Translation of the mtDNA-encoded proteins is further affected by the observed loss of the mitochondrial elongation factor-tu. In turn, depletion of rhodanese may increase the formation of ROS, especially mitochondrial superoxide anion radicals (Krueger et al, 2010). As a result, ROS accumulation and therefore oxidative stress may occur, especially since proteins involved in redox homeostasis including catalase, glutathione S-transferase and peroxiredoxin-1, 2 and 5 were also observed to decrease.…”

Section: Colonmentioning

confidence: 98%

Proteome analysis in the assessment of ageing

Nkuipou‐Kenfack

Koeck

Mischak

et al. 2014

Ageing Research Reviews

View full text Add to dashboard Cite

Section: Colonmentioning

confidence: 98%

Proteome analysis in the assessment of ageing

Nkuipou‐Kenfack

Koeck

Mischak

et al. 2014

Ageing Research Reviews

View full text Add to dashboard Cite

“…In addition, rhodanese induction might contribute to protection of normal tissues from acute high-dose irradiation in the case of radio-cancer therapy like anti-oxidants, which have been investigated for their protective action [35,36]. In addition, as it has been demonstrated that the reduction of rhodanese expression indicates an increase of oxidative stress and predicts mortality in hemodialysis patients; therefore, its expression might be a prognostic indicator [37]. …”

Section: Medical Relevance Of Rhodanese Functionmentioning

confidence: 99%

Roles of Sulfur Metabolism and Rhodanese in Detoxification and Anti-Oxidative Stress Functions in the Liver: Responses to Radiation Exposure

Nakajima¹

2015

Med Sci Monit

View full text Add to dashboard Cite

Organisms must confront various environmental stresses. The liver is central to protecting against such stresses in mammals, and it has many detoxification and anti-oxidative stress functions. Radiation is a source of oxidative stress and is known to affect the liver and induce anti-oxidative responses. The detoxification enzyme rhodanese, which is also called thiosulfate sulfurtransferase (TST), has been demonstrated to be induced in the liver in response to radiation. Cyanide detoxification is a function of the liver, and rhodanese is a key enzyme involved in sulfur metabolism in that detoxification. Though the anti-oxidative stress system in which sulfur molecules such as thiol compounds are involved has attracted attention as a defense against radiation, detoxification enzymes may have other roles in this defense. Understanding how these functions are affected by alterations of sulfur metabolism (including thiol compounds) after irradiation would help uncover their roles in defense against cancer and other deleterious health effects, as well as environmental stress responses. This article reviews the roles of sulfur-related metabolism in oxidative stress regulation and detoxification for recovery from liver damage after radiation exposure, with particular attention to recent findings of sulfur-related enzymes such as rhodanese, which is unique in sulfur metabolism.

show abstract

“…SCN-is a small, acidic pseudohalide thiolate that is ubiquitously found in the extracellular fluids, including plasma and saliva. SCN-is synthesized from cyanide by mitochondrial rhodanese or enters the blood from the diet (18). Chronic renal failure patients undergoing hemodialysis showed a reduction in SCN-formation, indicating reduction cyanide detoxication capability due to the parallel regulation of rhodanese (18).…”

Section: Discussionmentioning

confidence: 99%

Differential Molecular Signature of Human Saliva Using ATR-FTIR Spectroscopy for Chronic Kidney Disease Diagnosis

et al. 2019

View full text Add to dashboard Cite

The symptoms of chronic kidney disease (CKD) are often not specific or absent in the early stages of this illness. Therefore, there is a demand for developing low cost, non-invasive and highly accurate platforms for CKD diagnostics. We hypothesized that the level of specifics salivary components changes when CKD is emplace, which could be clinically used to discriminate CKD patients from healthy subjects. The present study aimed to compare salivary components between CKD patients and matched control subjects by using attenuated total reflection-Fourier Transform Infrared (ATR-FTIR) spectroscopy. The predictive power of salivary components was evaluated by receiver operating characteristic (ROC) curves. Several components were identified, and 4 of them showed different expression (p<0.05) between CKD and control subjects. Thiocyanate (SCN-, 2052 cm-1) and phospholipids/carbohydrates (924 cm-1) vibrational modes using original and second-derivative spectra by ATR-FTIR could potentially be used as salivary biomarkers to differentiate CKD than control subjects. The combination of original and second-derivative spectra by ATR-FTIR of 924 cm-1 vibrational modes could reach 92.8% sensitivity and 85.7% specificity for CKD detection. Despite, the limitation of our investigation, the acquired data indicates that salivary vibrational modes by ATR-FTIR platform should be further explored as an auxiliary diagnostic tool for CKD.

show abstract

Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients

Cited by 25 publications

References 35 publications

Proteome analysis in the assessment of ageing

Proteome analysis in the assessment of ageing

Roles of Sulfur Metabolism and Rhodanese in Detoxification and Anti-Oxidative Stress Functions in the Liver: Responses to Radiation Exposure

Differential Molecular Signature of Human Saliva Using ATR-FTIR Spectroscopy for Chronic Kidney Disease Diagnosis

Contact Info

Product

Resources

About