Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus

Safiulina, Victoria F.; Zacchi, Paola; Taglialatela, Maurizio; Yaari, Yoel; Cherubini, Enrico

doi:10.1113/jphysiol.2008.156257

Cited by 64 publications

(63 citation statements)

References 58 publications

(86 reference statements)

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“…A similar compensatory upregulation of intrinsic neuronal excitability was seen within a few hours after pharmacological block of NKCC1 in WT slices. The intrinsic properties of the neonatal CA3 pyramidal neurons are shaped by a number of factors, including the persistent Na ϩ current, the slow Ca ϩ -activated K ϩ current, I h , and Kv7/M channels (Bender et al, 2005;Sipilä et al, 2006a;Safiulina et al, 2008). Additional work is needed to identify the detailed mechanisms that account for the increase in the spiking propensity of the NKCC1 Ϫ/Ϫ neurons.…”

Section: Discussionmentioning

confidence: 99%

Compensatory Enhancement of Intrinsic Spiking upon NKCC1 Disruption in Neonatal Hippocampus

Sipilä¹,

Huttu²,

Yamada³

et al. 2009

J. Neurosci.

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Depolarizing and excitatory GABA actions are thought to be important in cortical development. We show here that GABA has no excitatory action on CA3 pyramidal neurons in hippocampal slices from neonatal NKCC1 Ϫ/Ϫ mice that lack the Na-K-2Cl cotransporter isoform 1. Strikingly, NKCC1 Ϫ/Ϫ slices generated endogenous network events similar to giant depolarizing potentials (GDPs), but, unlike in wild-type slices, the GDPs were not facilitated by the GABA A agonist isoguvacine or blocked by the NKCC1 inhibitor bumetanide. The developmental upregulation of the K-Cl cotransporter 2 (KCC2) was unperturbed, whereas the pharmacologically isolated glutamatergic network activity and the intrinsic excitability of CA3 pyramidal neurons were enhanced in the NKCC1 Ϫ/Ϫ hippocampus. Hence, developmental expression of KCC2, unsilencing of AMPA-type synapses, and early network events can take place in the absence of excitatory GABAergic signaling in the neonatal hippocampus. Furthermore, we show that genetic as well as pharmacologically induced loss of NKCC1-dependent excitatory actions of GABA results in a dramatic compensatory increase in the intrinsic excitability of glutamatergic neurons, pointing to powerful homeostatic regulation of neuronal activity in the developing hippocampal circuitry.

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Section: Discussionmentioning

confidence: 99%

Compensatory Enhancement of Intrinsic Spiking upon NKCC1 Disruption in Neonatal Hippocampus

Sipilä¹,

Huttu²,

Yamada³

et al. 2009

J. Neurosci.

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“…We do not exclude the possibility that in immature mEC LIII neurons weakness of M current may contribute to prolonged burst firing. Moreover, Kv7/M channel blocker linopirdine has only a minor effect on neonatal, in contrast to juvenile CA3 pyramidal neurons (Safiulina et al, 2008).…”

Section: Ionic Mechanisms Of Prolonged Intrinsic Bursting Activitymentioning

confidence: 99%

Spontaneous Bursting Activity in the Developing Entorhinal Cortex

Sheroziya

Halbach²,

Unsicker³

et al. 2009

J. Neurosci.

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-sensitive nonspecific cationic current (I CAN ) and the persistent Na ϩ current (I Nap ) underlie this effect. Indeed, a 0.2-1 s suprathreshold current step stimulus elicited a terminated plateau potential in these neurons. fp recordings at P5-P7 showed periodic spontaneous glutamate receptormediated events (sharp fp events or prolonged fp bursts) which were blocked by FFA. Slow-wave network oscillations become a dominant pattern at P11-P13. We conclude that prolonged intrinsic bursting activity is a characteristic feature of developing medial EC layer III neurons that might be involved in neuronal and network maturation.

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“…It has been used to great effect in unravelling the dynamics of plateau or square wave bursting in pancreatic islets [5], trigeminal motoneurons [10], and neonatal CA3 hippocampal principal neurons [46]. The classical slow/fast splitting is also useful in explaining how pseudo-plateau bursting can be converted to plateau bursting [54].…”

Section: The δ-Viewpointmentioning

confidence: 99%

Multiple Geometric Viewpoints of Mixed Mode Dynamics Associated with Pseudo-plateau Bursting

Vo¹,

Bertram²,

Wechselberger³

2013

SIAM J. Appl. Dyn. Syst.

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Abstract. Pseudo-plateau bursting is a type of oscillatory waveform associated with mixed mode dynamics in slow/fast systems and commonly found in neural bursting models. In a recent model for the electrical activity and calcium signaling in a pituitary lactotroph, two types of pseudo-plateau bursts were discovered: one in which the calcium drives the bursts and another in which the calcium simply follows them. Multiple methods from dynamical systems theory have been used to understand the bursting. The classic 2-timescale approach treats the calcium concentration as a slowly varying parameter and considers a parametrized family of fast subsystems. A more novel and successful 2-timescale approach divides the system so that there is only one fast variable and shows that the bursting arises from canard dynamics. Both methods can be effective analytic tools, but there has been little justification for one approach over the other. In this work, we use the lactotroph model to demonstrate that the two analysis techniques are different unfoldings of a 3-timescale system. We show that elementary applications of geometric singular perturbation theory in the 2-timescale and 3-timescale methods provide us with substantial predictive power. We use that predictive power to explain the transient and long-term dynamics of the pituitary lactotroph model.

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Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus

Cited by 64 publications

References 58 publications

Compensatory Enhancement of Intrinsic Spiking upon NKCC1 Disruption in Neonatal Hippocampus

Compensatory Enhancement of Intrinsic Spiking upon NKCC1 Disruption in Neonatal Hippocampus

Spontaneous Bursting Activity in the Developing Entorhinal Cortex

Multiple Geometric Viewpoints of Mixed Mode Dynamics Associated with Pseudo-plateau Bursting

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