Low expression of glucocorticoid receptors in children with steroid-resistant nephrotic syndrome

Hammad, Ayman; Yahia, Sohier; Gouida, Mona S.; Bakr, Ashraf; El-Farahaty, Reham M.

doi:10.1007/s00467-012-2385-4

Cited by 19 publications

(19 citation statements)

References 20 publications

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“…In agreement with our study, Hammad et al (2013) (15) found that 65% of SRNS were males and Shah et al (2015) (16) found that 66.7% of their SRNS patients were males.…”

Section: Discussionsupporting

confidence: 93%

Osteocalcin Level in Children with Steroid Dependent/Frequently Relapsing and Steroid Resistant Nephrotic Syndrome

et al. 2017

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Background: Children with nephrotic syndrome (NS) may be at risk for metabolic bone disease because of biochemical derangement caused by renal disease as well as steroid therapy. Osteocalcin (OC) functions as an inhibitor of bone mineralization. We aimed to evaluate linear growth and bone turnover markers (including serum osteocalcin) in children with steroid-dependant/frequentlyrelapsing and steroid resistant NS in comparison to a matched control group.

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“…In agreement with our study, Hammad et al (2013) (15) found that 65% of SRNS were males and Shah et al (2015) (16) found that 66.7% of their SRNS patients were males.…”

Section: Discussionsupporting

confidence: 93%

Osteocalcin Level in Children with Steroid Dependent/Frequently Relapsing and Steroid Resistant Nephrotic Syndrome

et al. 2017

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“…Bagdasorova et al 13 found an increase in GCR expression in patients with steroid sensitive and decrease in steroid resistance NS. Similar results were obtained by Ayman et al, 14 who found lower GCR expression on lymphocytes in steroid resistance NS in comparisons to steroid sensitive NS and control. Han et al 15 showed that glomerular GCR expression was significantly lower in late than in early steroid responder adults with NS.…”

Section: Discussionsupporting

confidence: 80%

Glucocorticoid receptors expression and histopathological types in children with nephrotic syndrome

et al. 2014

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Background: Some children with idiopathic nephrotic syndrome (NS) patients fail to respond even when given high dose of steroid. The aim of this study was to assess the GCR expression on the T lymphocytes of children with NS and its relation to the response to steroid and to histopathological type. Methods: Forty-six pediatric patients with idiopathic NS and 20 age and sex matched apparently healthy children as controls were included. Flow cytometry was employed to determine the percentage of CD3+/GCR+ cells which then correlated with pattern of steroid response. Renal biopsy was done for steroid-dependent and steroid-resistant cases for determination of the underlying histopathological type. Results: The mean percentage of T lymphocyte expression of GCRs (CD3+/GCR) was significantly higher in early steroid responders than in late responders and was slightly lower than the controls. There was a significantly lower GCRs expression in steroid-resistant patients in comparison to early responders, late responders and controls. Renal biopsy showed that most cases of late responders were of the focal segmental glomerulosclerosis (FSGS) type. The mean percentage of lymphocyte expression of GCRs was significantly higher in patients with minimal change disease (MCD) compared to patients with FSGS. Conclusion: Evaluation of the expression of intracellular GCRs in T lymphocytes at time of diagnosis of NS can predict the response to steroid therapy and can help in determination of the outcome of NS patients regarding future relapses.

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“…Ghobrial et al, [14] found that 85% of the SSNS group, 75% of the SDNS group and 90% of the SRNS group were males. Hammad et al, [15] found that 65% of SRNS were males and Shah et al [16] found that 66.7% of their SRNS patients were males. There was no significant difference between the subgroups of nephrotic patients regarding sex (p-value = 0.057).…”

Section: Resultsmentioning

confidence: 99%

Vitamin D level in nephrotic syndrome, Factors of impact?

Marzouk

Ghobrial

Khorshied

et al. 2019

GEGET

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Introduction Nephrotic syndrome (NS) usually responds to steroid therapy; however, the majority of children relapse, resulting in prolonged and repeated courses of steroid therapy. Vitamin D is a vital component of bone metabolism and calcium homeostasis. Maintenance of adequate levels of vitamin D is recommended to maintain good bone health and other organ systems of NS patients. The study aimed to assess serum 25 (OH) D levels in children with NS, compare its level with healthy age and sex-matched controls and compare its level in different types of NS. Patients and Methods It was a cross-sectional study for measuring 25(OH) D levels in 60 patients with NS and 60 apparently healthy children, to be compared as controls. Nephrotic patients were classified as steroid sensitive (20 cases) steroid dependent (20cases), and steroid resistant (20 cases). Serum 25-hydroxyvitamin [25(OH) D] was measured using Enzyme Linked Immune Sorbent Assay (ELISA) technique. Results Serum 25(OH) D was significantly lower in NS patients than control group (p<0.001).Steroid resistant nephrotic syndrome (SRNS) patient group showed the highest drop than the other 2 groups (p<0.001). There was significant negative correlation between vitamin D level and number of relapses, 24 hours urinary proteins and serum cholesterol. Conclusion It is recommended that NS patients especially on long term steroid therapy should undergo regular follow up of vitamin D level and early prophylactic supplementation with calcium and vitamin D should be advised.

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Low expression of glucocorticoid receptors in children with steroid-resistant nephrotic syndrome

Abstract: Patients with initial SRNS showed decreased GR expression in peripheral blood mononuclear cells (PBMC) before starting therapy, and this low expression may be one of the pathophysiological mechanisms of steroid resistance in these children.

Cited by 19 publications

References 20 publications

Osteocalcin Level in Children with Steroid Dependent/Frequently Relapsing and Steroid Resistant Nephrotic Syndrome

Osteocalcin Level in Children with Steroid Dependent/Frequently Relapsing and Steroid Resistant Nephrotic Syndrome

Glucocorticoid receptors expression and histopathological types in children with nephrotic syndrome

Vitamin D level in nephrotic syndrome, Factors of impact?

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