Low etiologic fraction for human papillomavirus in larynx squamous cell carcinoma

Cequier, Ángel; Resteghini, Carlo; Swanson, Benjamin J.; Pickard, Robert K. L.; Jiang, Bo; Xiao, Weihong; Mena, Marisa; Kreinbrink, P.J.; Chio, Eugene; Gillison, Maura L.

doi:10.1016/j.oraloncology.2016.08.009

Cited by 31 publications

(31 citation statements)

References 23 publications

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“…33 We found a relatively high proportion of tumors positive for HPV16 DNA; however, recent studies using multiple biomarkers for HPV status have estimated the attributable fraction of HPV in LSCC to be <5%, suggesting that HPV rarely causes LSCC but is instead a bystander infection. 34,35 Therefore, the number of tumors caused by HPV may be overestimated in our study. However, the large cohort size of 812 patients and the HPV16 DNA/p16 combined test for HPV detection may offset some of these limitations.…”

Section: Discussionmentioning

confidence: 74%

“…Finally, the method we used for HPV detection was not E6/E7 mRNA qRT‐PCR, which is the gold standard assay for transcriptionally active HPV status . We found a relatively high proportion of tumors positive for HPV16 DNA; however, recent studies using multiple biomarkers for HPV status have estimated the attributable fraction of HPV in LSCC to be <5%, suggesting that HPV rarely causes LSCC but is instead a bystander infection . Therefore, the number of tumors caused by HPV may be overestimated in our study.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic implications of human papillomavirus status and p16 expression in laryngeal squamous cell carcinoma

et al. 2019

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Background The purpose of this study was to investigate significance of HPV16 DNA/p16 for survival of patients with laryngeal squamous cell carcinoma (LSCC). Methods HPV16 DNA and p16 status in 812 LSCC patients were determined. The survival was performed using Kaplan‐Meier estimates and Cox model. Results Compared with HPV negativity, adjusted HRs for HPV16 positivity were 0.57, 95% CI, 0.38 to 0.87; 0.60, 0.40 to 0.88; and 0.65, 0.46 to 0.94 for disease‐specific survival (DSS), recurrence‐free survival (RFS), and overall survival (OS), respectively. Additionally, for p16 expression, aHRs were 0.68, 95% CI, 0.48 to 0.96; 0.72, 0.52 to 0.98; and 0.73, 0.54 to 0.99 for DSS, RFS, and OS, respectively. Finally, for combined analysis, patients with both HPV16‐positivity/p16‐positivity had much better prognosis than those with either negativity. Such above survivals are more significantly better in never smokers. Conclusion Our findings suggest that HPV16/p16 may affect survival outcomes of LSCC patients, particularly in never smokers.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Prognostic implications of human papillomavirus status and p16 expression in laryngeal squamous cell carcinoma

et al. 2019

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“…Interestingly, this finding places Algeria, among the countries where LC would be the less affected by HPV infections [ 18 , 25 ]. Indeed, several authors have described higher HPV prevalence for Latin-America compared with Western-Africa, Southern-Europe, USA and Southwestern-Asia [ 17 , 19 – 21 ]. When taking into account the impact that the screening techniques may exert on HPV detection [ 17 , 19 , 25 ], we observed that HPV prevalence in Algeria was inferior to that described for the larynx in the world [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the last decade, human papillomavirus (HPV) infections have been associated with 22.1% of head and neck squamous cell carcinomas (HNSCC) [ 15 ] and have been related to 15–20% of those occurring in nonsmoking and nondrinking patients [ 16 ]. Marked differences in HPV attributable fraction in oral tumors have been shown to prevail between different populations and geographical regions [ 17 – 21 ]; these variations being due to heterogeneous testing procedures taking principally into account different number of biomarkers [ 15 , 22 ]. Consequently, the previously over estimation of HPV associated fraction in the larynx, has been recently reevaluated to lower figures varying between 1.5% and 5.7%, depending on the biomarkers used (HPV DNA/mRNA/p16 INK4a ) [ 15 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative assessment of HPV, alcohol and tobacco etiological fractions in Algerian patients with laryngeal squamous cell carcinoma

Kariche

Hortal

Benyahia

et al. 2018

Infect Agents Cancer

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BackgroundDespite the increasing incidence of laryngeal squamous cell carcinoma (LSCC) in Algeria, scarce information is available on the importance of the preventable etiological factors which may drive the disease. Remarkably, a significant number of cases occur in nonsmoker and nondrinker patients; hence, suggesting that alternative risk factors, like Human papillomavirus (HPV), might be etiologically involved. To gain more insight on the risk factors associated with the disease in the country, we evaluated the etiological fraction of HPV in comparison to tobacco and alcohol intake in LSCC patients.MethodsTo evaluate the etiopathologic fraction (EF) for HPV compared to history of tobacco and alcohol in LSCC, HPV DNA presence in 46 invasive and 3 non-invasive formalin-fixed paraffin-embedded laryngeal tumors was screened using the SPF10-DEIA-LiPA25 Assay. Demographic data and information related to exposure to the risk factors were gathered through interviewer-assisted questionnaires.ResultsWe observed that 40.8% of all LSCC cases were associated with smoking, 40.8% had combined tobacco and alcohol exposure history, and 14.3% did not show prior exposure to either risk factor. 1 out of 3 in-situ carcinoma cases was positive for HPV-6. HPV prevalence was null in the invasive tumors. HPV DNA was detected in 2.38% for all studied cases. 10.2% of LSCC patients did not associate with any of the studied risk factors.ConclusionHere we show that HPV etiological fraction in LSCC Algerian patients is low and smoking and alcohol remain the principal etiopathologic risk for LSCC burden in Algeria.

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“…Oral cavity, hypopharynx, and larynx cancers are unlikely to be HPV-related. [21][22][23][24][25] Hence, p16 testing is not routinely ordered for tumors outside the oropharynx and thus was not evaluated in patients with oral cavity, hypopharynx, and larynx cancer.…”

Section: Methodsmentioning

confidence: 99%

Impact of a tobacco treatment program on abstinence and survival rates among current smokers with head and neck squamous cell carcinoma

et al. 2020

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Background Approximately one quarter of head and neck cancer (HNC) patients smoke cigarettes at the time of diagnosis. Despite HNC guideline recommendations to treat tobacco dependence, the effectiveness of treatment in this population is poorly described. Methods This retrospective cohort review evaluated 117 current smokers with p16‐negative mucosal head and neck squamous cell carcinoma prospectively enrolled in a tobacco treatment program. Seven‐day point prevalence tobacco abstinence rates at 9 months and survival outcomes were compared among abstinent and nonabstinent groups. Results Median follow‐up among survivors was 62.4 months. Forty percent of patients were abstinent at 9 months according to intention‐to‐treat analysis. After adjustment for age, comorbidity and site, abstinent stage I to II patients had a decreased risk of death compared to smoking stage I to II patients (HR 0.15, 95% CI 0.03‐0.82). Conclusions High cohort abstinence rates and favorable survival among abstinent patients with early‐stage HNC confirm the importance of tobacco dependence treatment in this population.

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Low etiologic fraction for human papillomavirus in larynx squamous cell carcinoma

Cited by 31 publications

References 23 publications

Prognostic implications of human papillomavirus status and p16 expression in laryngeal squamous cell carcinoma

Prognostic implications of human papillomavirus status and p16 expression in laryngeal squamous cell carcinoma

Comparative assessment of HPV, alcohol and tobacco etiological fractions in Algerian patients with laryngeal squamous cell carcinoma

Impact of a tobacco treatment program on abstinence and survival rates among current smokers with head and neck squamous cell carcinoma

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