Low Energy Levels in Thiamine-Deficient Encephalopathy

Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: An in vitro model for the study of cell death mechanisms in Wernicke's encephalopathy

“…Cerebellar degeneration associated with a loss of Purkinje cells as well as a shrinkage of the cerebellar cortex and the molecular and granule cell layers have also been reported in TD (Collins and Converse, 1970;Phillips et al, 1987Phillips et al, , 1990). In addition, positron emission tomography (PET) studies reveal reduced cerebellar glucose utilization (Gilman et al, 1990), which may be a consequence of severe compromise of energy metabolism in thiamine deficiency (Aikawa et al, 1984).…”

Protective effects of the glutamate antagonist MK-801 on pyrithiamine- induced lesions and amino acid changes in rat brain

“…Decreased cerebral energy production (Aikawa et al, 1984) lactate accumulation, and decreased pH (Hakim and Pappius, 1983;Hakim, 1984;Parker et al, 1984) and decreased transketolase activity (McCandless and Schenker, 1968;Pincus and Wells, 1972;Gibson et al, 1984;Butterworth, 1986) have been suggested as possible mechanisms of thiamine deficiency-induced cell death. The type of neuronal damage observed in pyrithiamine-induced thiamine deficiency (PTD) rats closely resembles that observed following anoxia (Papp et al,198 1) and glutamate-induced excitotoxicity (Armstrong-James et al, 1988).…”

Increased Densities of Binding Sites for the “Peripheral-Type” Benzodiazepine Receptor Ligand [3H]PK11195 in Vulnerable Regions of the Rat Brain in Thiamine Deficiency Encephalopathy

“…In both experimental thiamine defi ciency and WKS, there is a predilection for neuro nal loss in thalamic, midbrain, and brainstem struc tures (Troncoso et al, 1981;Aikawa et al, 1984;Victor et al, 1989). Neuronal loss and concomitant gliosis are characteristic features of WKS in hu mans (Torvik et al, 1982;Harper, 1983;Victor et al, 1989).…”