Low dynamin 2 expression is associated with tumor invasion and metastasis in invasive squamous cell carcinoma of cervix

Lee, Yoo-Young; Do, In‐Gu; Park, Young Ae; Choi, Jung-Joo; Song, Sang Yong; Kim, Chul Jung; Kim, Min Kyu; Song, Tae Jong; Park, Hwang Shin; Choi, Chel Hun; Kim, Tae-Joong; Kim, Byoung-Gie; Lee, Jeong‐Won; Bae, Duk-Soo

doi:10.4161/cbt.10.4.12275

Cited by 16 publications

(12 citation statements)

References 31 publications

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“…endocytosis (11,12), and this may eventually lead to progression to cervical intraepithelial neoplasm and invasive cervical cancer. Interestingly, dynamin 2 was expressed at different levels with disease progression in our previous studies (2,3).…”

Section: Discussionmentioning

confidence: 80%

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Dynamin 2 Inhibitors as Novel Therapeutic Agents Against Cervical Cancer Cells

Lee

Jeon

Lee

et al. 2016

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Section: Discussionmentioning

confidence: 80%

“…studies showed that dynamin 2, a member of the large GTPase superfamily, was differentially expressed between normal cervical epithelium, cervical intraepithelial neoplasm, and invasive cervical cancer tissues and had a prognostic role for predicting recurrence (2)(3)(4).…”

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confidence: 99%

Dynamin 2 Inhibitors as Novel Therapeutic Agents Against Cervical Cancer Cells

Lee

Jeon

Lee

et al. 2016

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“…Lee et al reported that low DNM2 expression was associated with tumor invasion and metastasis in invasive squamous cell carcinoma of the cervix 28. This group also demonstrated that inhibition of DNM2 enhanced the expression of metalloproteinase-2 ( MMP2 ), a type IV collagenase,29 whose elevated expression is associated with various carcinomas, including HCC 30–32…”

Section: Discussionmentioning

confidence: 96%

Dynamin 3: a new candidate tumor suppressor gene in hepatocellular carcinoma detected by triple combination array analysis

Inokawa¹,

Nomoto²,

Hishida³

et al. 2013

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BackgroundTo identify genes associated with hepatocellular carcinoma (HCC) pathogenesis, we developed a triple combination array strategy comprising methylation, gene expression, and single nucleotide polymorphism (SNP) array analysis.MethodsSurgical specimens obtained from a 68-year-old female HCC patient were analyzed by triple combination array, and identified Dynamin 3 (DNM3) as a candidate tumor suppressor gene in HCC. Subsequently, samples from 48 HCC patients were evaluated for DNM3 methylation and expression status using methylation specific polymerase chain reaction (PCR; MSP) and semi-quantitative reverse transcriptase (RT)-PCR, respectively. The relationship between clinicopathological factors and DNM3 methylation status was also investigated.ResultsDNM3 was shown to be hypermethylated (methylation value 0.879, range 0–1.0) in cancer tissue compared with adjacent normal tissue (0.213) by methylation array in the 68-year-old female patient. Expression arrays revealed decreased expression of DNM3 in cancerous tissue. SNP arrays revealed that the copy number of chromosome 1q24.3, in which DNM3 resides, was normal. MSP revealed hypermethylation of the DNM3 promoter region in 33 of 48 tumor samples. A trend toward decreased DNM3 expression was observed in patients with DNM3 promoter methylation (P = 0.189). Furthermore, patients with reduced expression of DNM3 in tumor tissues exhibited worse prognosis with decreased disease specific survival compared to patients without decreased expression (P = 0.014).ConclusionThe present study indicates that a triple combination array strategy is an effective method to detect novel genes related to HCC. We propose that DNM3 is a tumor suppressor gene in HCC.

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“…Lee et al 2010;Eppinga et al 2012 Endophilin Induces membrane curvature during synaptic vesicle formation. Binds dynamin and synpatojanin.…”

Section: Cai Et Al 2010mentioning

confidence: 99%