Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity: a case–control study

Bálsamo, Sandor; Mota, Lícia Maria Henrique da; Carvalho, Jozélio Freire de; Nascimento, Dahan da Cunha; Tibana, Ramires Alsamir; Santana, Frederico Santos de; Moreno, Ricardo Lima; Gualano, Bruno; Santos-Neto, Leopoldo Luiz dos

doi:10.1186/1471-2474-14-263

Cited by 47 publications

(41 citation statements)

References 23 publications

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“…Chair-stand time was measured as the time to complete 5 chair-stands from a standard chair without using one’s arms (35). Peak isokinetic knee torque and chair-stand time were chosen because these are commonly used proxy measures for muscle strength among rheumatologic and non-rheumatologic populations (3, 4, 9, 11, 19, 35–37). …”

Section: Methodsmentioning

confidence: 99%

“…In SLE, only limited data exist describing the relationships between muscle strength and physical disability (19, 20), and to our knowledge no data have been published that examine the role of regional muscle mass and physical disability in SLE. Similar to RA, SLE predisposes to increased fat mass and decreased lean mass (21–23), and there is a high burden of physical disability among individuals with SLE (24–26).…”

Section: Introductionmentioning

confidence: 99%

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Muscle Strength, Muscle Mass, and Physical Disability in Women With Systemic Lupus Erythematosus

Andrews

Trupin

Schmajuk

et al. 2014

Arthritis Care & Research

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Objective Limited data exist describing relationships between muscle strength, muscle mass, and physical disability among individuals with systemic lupus erythematosus (SLE). The present study examines the relationship of muscle strength and muscle mass with physical disability among adult women with SLE. Methods One hundred forty-six women from a longitudinal SLE cohort participated in the study. All measures were collected during an in-person research visit. Lower extremity muscle strength was assessed by peak knee torque of extension and flexion and by chair-stand time. Total lean body mass, appendicular lean mass, and fat mass (kg/m2) were measured by whole-body dual energy absorptiometry. Self-reported physical disability was assessed using the SF-36 Physical Functioning subscale and Valued Life Activities (VLA) Disability scale. Spearman’s rank correlation coefficients tested the correlations between muscle strength, muscle mass, and disability scores. Regression analyses modeled the effect of lower extremity muscle strength and mass on SF-36 and VLA disability scores controlling for age, SLE duration, SLE disease activity measured with the Systemic Lupus Activity Questionnaire (SLAQ), physical activity level, prednisone use, body composition, and depression. Results On all measures, reduced lower extremity muscle strength was associated with poorer SF-36 and VLA disability scores. Trends persisted after adjustment for covariates. Muscle mass was moderately correlated with muscle strength, but did not contribute significantly to adjusted regression models. Conclusions Lower extremity muscle strength, but not muscle mass, was strongly associated with physical disability scores. While further studies are needed, these findings suggest that improving muscle strength may reduce physical disability among women with SLE.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Muscle Strength, Muscle Mass, and Physical Disability in Women With Systemic Lupus Erythematosus

Andrews

Trupin

Schmajuk

et al. 2014

Arthritis Care & Research

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show abstract

“…In addition, the experience of this work brings to light a warning to health professionals, since the similarity in terms of cardiovascular and functional condition of individuals with different levels of control of RA, once again, shows the need for referral and indication of the practice of physical activities for individuals with RA, even though it was diagnosed early in the disease and well controlled over time. The reduced CCV and functional in individuals with RA also appears to be characteristic of other rheumatologic and autoimmune diseases such as systemic lupus erythematosus (SLE) [40] [41] and fibromyalgia [42], when compared to individuals of the same genus and age [25] or the elderly [26].…”

Section: Discussionmentioning

confidence: 99%

Six-Minute Walk Test in Patients with Rheumatoid Arthritis

Bálsamo¹,

Gomides²,

Mota³

et al. 2019

OJRA

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Background: The 6-minute walk test (6TC) was initially used as an instrument for assessing physical and cardiorespiratory capacity, but is currently being used to monitor treatments, and compare physical interventions and prognostic evaluation. Although already recognized as a research method in several specialties, 6TC has not been used in rheumatology. Patients with rheumatoid arthritis (RA) may have impaired functional capacity as well as increased cardiovascular mortality. An adequate functional evaluation of these patients is necessary and the 6TC may be useful in this sense. Objective: The aim of this study was to perform the 6-minute walk test in RA patients and to compare the performance with a control group. Method: A cross-sectional study was carried out in which the sample consisted of 85 women, 46 patients with rheumatoid arthritis and 39 healthy controls. A descriptive analysis of the data was performed. One-Way ANOVA methodology was used to compare the patient and control groups followed by the graphic analysis. Results: The distance walked on the 6TC by RA patients was on average 522.2 meters. In the distance control group found in the 6TC was on average 628.8 meters, the difference being statistically significant. Conclusion: In this study the distance covered in 6TC by women with RA was lower than that of healthy women of the same age.

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“…[8][9][10] Consequently, the development of cardinal PD symptoms is observed, including tremor, postural instability, muscle stiffness, and bradykinesia, [11][12][13][14][15][16][17][18] which is considered the most disabling disease symptoms. 16,19,20 Muscle weakness has also been reported as an important PD symptom, and it is related to bradykinesia, because they share common pathophysiological mechanisms, 12,13,21,22 also being responsible for a functional performance decrease. 13,16,23 The PD traditional therapeutic approach includes Levodopa (main dopaminergic medication), dopaminergic agonists, catechol-O-methyltransferase inhibitors and nondopaminergic agents.…”

Section: Introductionmentioning

confidence: 99%

“…17,[37][38][39] A key element to understand the DP training resistance benefit is in his neuronal benefit. This intervention's model shows up as a solution to reduce the bradykinesia, 12,13,22,40 main effect of dopaminergic med ication, which produces improvements in brain connectivity, muscle activation, and functional performance. 41,42 Furthermore, it is a new field of study, and it's still not totally clear, how bradykinesia may be affected by exercise.…”

Section: Introductionmentioning

confidence: 99%

<p>Progressive Resistance Training Improves Bradykinesia, Motor Symptoms and Functional Performance in Patients with Parkinson’s Disease</p>

Filho¹,

Chaves²,

Martins³

et al. 2020

CIA

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Purpose: Bradykinesia and muscle weaknesses are common symptoms of Parkinson's Disease (PD) and are associated with impaired functional performance, increased risk of falls, and reduced quality of life. Recent studies have pointed to progressive resistance training (PRT) as an effective method to control and reduce these symptoms, increasing possibilities to treat the disease. However, few studies have focused on assessing the PRT effects in the short-term. Therefore, the present study aimed to assess the short-term PRT effects on people with PD, in order to offer new parameters for a better understanding of its effects, so as an adequation and PRT use as a complementary therapy. Patients and Methods: Forty individuals diagnosed with PD from stage 1 to 3 on the Hoehn and Yahr scale took part on the study and were allocated into 2 groups; Training Group (TG) performed a 9-week RT program twice a week, and the Control Group (CG) attended disease lectures. Bradykinesia UPDRS subscale (BSS), knee extensors isokinetic strength, Ten Meters Walk Test (TMW), Timed Up&Go Test (TUG) and 30-Second Chair Stand (T30) were measured before and after the intervention period. Statistical significance was set at p ≤ 0.05. Results: Significant time was noted by the group interaction for all functional tests (TUG, T30, and TWM; all p < 0.01) and BSS (p < 0.01). Post hoc analyses revealed that these differences were driven by significant improvements in these dependent variables (all p < 0.01) while the CG remained unchanged (all p > 0.05). Moreover, TUG, T30, TWM, and BSS were significantly different between TG and CG in the post-training assessments (all p < 0.01). Isokinetic muscle strength was slightly increased in the TG (2.4%) and decreased in the CG (−2.2%), but statistical analyses did not reach significance for interaction but only a trend (p = 0.12). Conclusion:The results indicate that 9 weeks of PRT reduces bradykinesia and improves functional performance in patients with mild to moderate PD. These findings reinforce this mode of exercise as an important component of public health promotion programs for PD.

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Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity: a case–control study

Cited by 47 publications

References 23 publications

Muscle Strength, Muscle Mass, and Physical Disability in Women With Systemic Lupus Erythematosus

Muscle Strength, Muscle Mass, and Physical Disability in Women With Systemic Lupus Erythematosus

Six-Minute Walk Test in Patients with Rheumatoid Arthritis

<p>Progressive Resistance Training Improves Bradykinesia, Motor Symptoms and Functional Performance in Patients with Parkinson’s Disease</p>

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