Low doses of nanodiamonds and silica nanoparticles have beneficial hormetic effects in normal human skin fibroblasts in culture

Mytych, Jennifer; Wnuk, Maciej; Rattan, Suresh

doi:10.1016/j.chemosphere.2016.01.045

Cited by 51 publications

(29 citation statements)

References 56 publications

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“…Among those, silver nanoparticles (Ag-NPs), commercialized in household antiseptic sprays, food packaging, clothes and antimicrobial coatings of medical devices [ 9 , 10 , 11 ], caused biphasic dose–responses in different cell lines, i.e., lung, gastrointestinal and hepatic cells [ 12 , 13 , 14 ]. Moreover, nano-diamonds (NDs) and silica nanoparticles (SiO 2 -NPs) employed as drug delivery systems, magnetic resonance imaging contrast enhancers and biosensors for intracellular pathogens induced hormetic responses in dermal fibroblasts [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…Differently shaped and chemically composed NPs such as NDs and SiO 2 -NPs affected an hormetic response in cellular proliferation of human skin fibroblasts exposed for a sub-acute period (48 h) [ 15 ]. A comparable stimulation of cell growth and a wound healing promoting effect was evident also for longer exposure periods to non-cytotoxic concentrations (up to eight days).…”

Section: Resultsmentioning

confidence: 99%

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Nanoparticle Exposure and Hormetic Dose–Responses: An Update

Iavicoli

Leso

Fontana

et al. 2018

IJMS

107

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The concept of hormesis, as an adaptive response of biological systems to moderate environmental challenges, has raised considerable nano-toxicological interests in view of the rapid pace of production and application of even more innovative nanomaterials and the expected increasing likelihood of environmental and human exposure to low-dose concentrations. Therefore, the aim of this review is to provide an update of the current knowledge concerning the biphasic dose–responses induced by nanoparticle exposure. The evidence presented confirmed and extended our previous findings, showing that hormesis is a generalized adaptive response which may be further generalized to nanoscale xenobiotic challenges. Nanoparticle physico-chemical properties emerged as possible features affecting biphasic relationships, although the molecular mechanisms underlining such influences remain to be fully understood, especially in experimental settings resembling long-term and low-dose realistic environmental exposure scenarios. Further investigation is necessary to achieve helpful information for a suitable assessment of nanomaterial risks at the low-dose range for both the ecosystem function and the human health.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Nanoparticle Exposure and Hormetic Dose–Responses: An Update

Iavicoli

Leso

Fontana

et al. 2018

IJMS

107

View full text Add to dashboard Cite

show abstract

“…Increasing evidence suggests that many phytochemicals can activate pathways that prevent or reverse oxidative injury [55]. The Nrf2/HO-1 signaling pathway is crucial for neuroprotection against oxidative stress [32], [33], [34] and involved in the process of hormesis [36], [56], [57], [58]. Nrf2 is a stress-responsive transcriptional factor and an important effector protecting cells from oxidative injury, particularly neurodegenerative diseases.…”

Section: Discussionmentioning

confidence: 99%

Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

et al. 2017

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Berberine (BBR) is a renowned natural compound that exhibits potent neuroprotective activities. However, the cellular and molecular mechanisms are still unclear. Hormesis is an adaptive mechanism generally activated by mild oxidative stress to protect the cells from further damage. Many phytochemicals have been shown to induce hormesis. This study aims to investigate whether the neuroprotective activity of BBR is mediated by hormesis and the related signaling pathways in 6-OHDA-induced PC12 cells and zebrafish neurotoxic models. Our results demonstrated that BBR induced a typical hormetic response in PC12 cells, i.e. low dose BBR significantly increased the cell viability, while high dose BBR inhibited the cell viability. Moreover, low dose BBR protected the PC12 cells from 6-OHDA-induced cytotoxicity and apoptosis, whereas relatively high dose BBR did not show neuroprotective activity. The hormetic and neuroprotective effects of BBR were confirmed to be mediated by up-regulated PI3K/AKT/Bcl-2 cell survival and Nrf2/HO-1 antioxidative signaling pathways. In addition, low dose BBR markedly mitigated the 6-OHDA-induced dopaminergic neuron loss and behavior movement deficiency in zebrafish, while high dose BBR only slightly exhibited neuroprotective activities. These results strongly suggested that the neuroprotection of BBR were attributable to the hormetic mechanisms via activating cell survival and antioxidative signaling pathways.

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“…As they expected, selenium protected the cells from the adverse effects of AgNPs. Mytych et al [91] studied the prolonged effects of AgNPs in HT22s by treating the cells with a low concentration of AgNPs (5 μg/mL) for 48 h, and evaluated the cytophysiological effects 96 h following AgNP removal. Surprisingly, no toxicity was observed; conversely, the AgNPs modulated the HT22 proliferation and induced oxidative stress and 53BP1 recruitment.…”

Section: Cellular Effects Of Agnps On Neuronal Cellsmentioning

confidence: 99%

Silver Nanoparticle-Mediated Cellular Responses in Various Cell Lines: An in Vitro Model

Zhang

Shen

Gurunathan

2016

IJMS

231

137

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Silver nanoparticles (AgNPs) have attracted increased interest and are currently used in various industries including medicine, cosmetics, textiles, electronics, and pharmaceuticals, owing to their unique physical and chemical properties, particularly as antimicrobial and anticancer agents. Recently, several studies have reported both beneficial and toxic effects of AgNPs on various prokaryotic and eukaryotic systems. To develop nanoparticles for mediated therapy, several laboratories have used a variety of cell lines under in vitro conditions to evaluate the properties, mode of action, differential responses, and mechanisms of action of AgNPs. In vitro models are simple, cost-effective, rapid, and can be used to easily assess efficacy and performance. The cytotoxicity, genotoxicity, and biocompatibility of AgNPs depend on many factors such as size, shape, surface charge, surface coating, solubility, concentration, surface functionalization, distribution of particles, mode of entry, mode of action, growth media, exposure time, and cell type. Cellular responses to AgNPs are different in each cell type and depend on the physical and chemical nature of AgNPs. This review evaluates significant contributions to the literature on biological applications of AgNPs. It begins with an introduction to AgNPs, with particular attention to their overall impact on cellular effects. The main objective of this review is to elucidate the reasons for different cell types exhibiting differential responses to nanoparticles even when they possess similar size, shape, and other parameters. Firstly, we discuss the cellular effects of AgNPs on a variety of cell lines; Secondly, we discuss the mechanisms of action of AgNPs in various cellular systems, and try to elucidate how AgNPs interact with different mammalian cell lines and produce significant effects; Finally, we discuss the cellular activation of various signaling molecules in response to AgNPs, and conclude with future perspectives on research into AgNPs.

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Low doses of nanodiamonds and silica nanoparticles have beneficial hormetic effects in normal human skin fibroblasts in culture

Cited by 51 publications

References 56 publications

Nanoparticle Exposure and Hormetic Dose–Responses: An Update

Nanoparticle Exposure and Hormetic Dose–Responses: An Update

Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

Silver Nanoparticle-Mediated Cellular Responses in Various Cell Lines: An in Vitro Model

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