Low doses of ethanolic extract of Boldo (Peumus boldus) can ameliorate toxicity generated by cisplatin in normal liver cells of mice in vivo and in WRL-68 cells in vitro, but not in cancer cells in vivo or in vitro

Mondal, Jesmin; Bishayee, Kausik; Panigrahi, A. K.; Khuda‐Bukhsh, Anisur Rahman

doi:10.1016/s2095-4964(14)60045-5

Cited by 25 publications

(17 citation statements)

References 25 publications

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“…The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy than the ones described by Mondal et al 11 , but lower than those used by Lanhers et al 12 which have failed in previously reported experiments.…”

mentioning

confidence: 57%

“…On the other hand, lower doses of the same extract, ranging from 20 to 40 mg/Kg, have demonstrated to ameliorate toxicity generated by cisplatin in liver tissue in vivo 11 .…”

Section: Discussionmentioning

confidence: 99%

“…Boldo is popularly used in cases of hepatitis, hepatic colic, biliary lithiasis and intestinal disorders, and rheumatism, poor digestion, asthenia, dyspepsia, inappetence and other disorders 8 . Studies have demonstrated that polar extracts of Peumus boldus are able to display antioxidant activity 9 and reduce hepatic lipoperoxidation induced by cisplatin [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

“…As boldo and its chemical compounds have previously demonstrated beneficial properties on the Peumus boldus leaves [8][9][10][11][12] , the purpose of the current study is to assess the effect of aqueous extract of the Peumus Boldus on the liver proliferative response after hepatectomy in rodents.…”

Section: Introductionmentioning

confidence: 99%

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The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy

Figueiredo

Santana²,

Nardelli

et al. 2016

Acta Cir. Bras.

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PURPOSE:To assess the effect of aqueous extract of Peumus Boldus (AEPB) on the liver proliferative response after parcial hepatectomy of 70% (PH) in rodents. METHODS:Twenty Wistar rats were divided in two groups: AEPB100 (whose rats received 100mg/Kg of AEPB, once a day, orally, in 4 days prior to the first surgical procedure) and Vehicle (whose rats were treated similarly with distilled water). Both groups underwent PH. After 24 hours the remaining livers were removed for studying the proliferation of hepatocytes by Ki-67 and 2mL of blood were collected for serological assessment: cholesterol, glucose, triglycerides, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and total, direct and indirect bilirubin. All data were analyzed by Gaussian distribution. Statistically significant differences between mean values were analyzed using T Student's test. Non-Gaussian data were analyzed using Mann-Whitney's test. RESULTS:The liver of all these rats presented positive staining of Ki-67, indicating liver proliferation. Laboratory results showed no significant difference in serum values between the analyzed groups. The analysis of Ki-67 was significantly more positive in AEPB100 group than in Vehicle group. CONCLUSION:Aqueous extract of Peumus Boldus acute administration exerts significant positive effect on liver regeneration after 24h in rats that underwent parcial hepatectomy, while maintaining unchanged hepatic function.

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mentioning

confidence: 57%

“…On the other hand, lower doses of the same extract, ranging from 20 to 40 mg/Kg, have demonstrated to ameliorate toxicity generated by cisplatin in liver tissue in vivo 11 .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy

Figueiredo

Santana²,

Nardelli

et al. 2016

Acta Cir. Bras.

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“…Analysis of purified DNA from both viral stocks on alkaline agarose gels, followed by Southern blot assays revealed similar levels of the .4.5 kb viral genomes (Fig. 1f), as well as the viral capsid proteins on SDS-PAGE gels (Mondal et al, 2014), followed by Western blot analysis. The conventional 1 : 1 : 10 ratio of VP1 : VP2 : VP3 proteins (Fig.…”

mentioning

confidence: 83%

Productive life cycle of adeno-associated virus serotype 2 in the complete absence of a conventional polyadenylation signal

Wang

Yin

Wang

et al. 2015

Journal of General Virology

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We showed that WT adeno-associated virus serotype 2 (AAV2) genome devoid of a conventional polyadenylation [poly(A)] signal underwent complete genome replication, encapsidation and progeny virion production in the presence of adenovirus. The infectivity of the progeny virion was also retained. Using recombinant AAV2 vectors devoid of a human growth hormone poly(A) signal, we also demonstrated that a subset of mRNA transcripts contained the inverted terminal repeat (ITR) sequence at the 39 end, which we designated ITR in RNA (ITRR). Furthermore, AAV replication (Rep) proteins were able to interact with the ITRR. Taken together, our studies suggest a new function of the AAV2 ITR as an RNA element to mediate transgene expression from poly(A)-deleted mRNA.

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Nutlin‐3 treatment spares cisplatin‐induced inhibition of bone healing while maintaining osteosarcoma toxicity

Stine

Liu

Skinner

et al. 2016

Journal Orthopaedic Research

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The majority of Osteosarcoma (OS) patients are treated with a combination of chemotherapy, resection, and limb salvage protocols. These protocols include distraction osteogenesis (DO), which is characterized by direct new bone formation. Cisplatin (CDP) is extensively used for OS chemotherapy and recent studies, using a mouse DO model, have demonstrated that CDP has profound negative effects on bone repair. Recent oncological therapeutic strategies are based on the use of standard cytotoxic drugs plus an assortment of biologic agents. Here we demonstrate that the previously reported CDP-associated inhibition of bone repair can be modulated by the administration of a small molecule p53 inducer (nutlin-3). The effects of nutlin-3 on CDP osteotoxicity were studied using both pre- and post-operative treatment models. In both cases the addition of nutlin-3, bracketing CDP exposure, demonstrated robust and significant bone sparing activity (p < 0.01–0.001). In addition the combination of nutlin-3 and CDP induced equivalent OS tumor killing in a xenograft model. Collectively, these results demonstrate that the induction of p53 peri-operatively protects bone healing from the toxic effects of CDP, while maintaining OS toxicity.

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Low doses of ethanolic extract of Boldo (Peumus boldus) can ameliorate toxicity generated by cisplatin in normal liver cells of mice in vivo and in WRL-68 cells in vitro, but not in cancer cells in vivo or in vitro

Cited by 25 publications

References 25 publications

The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy

The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy

Productive life cycle of adeno-associated virus serotype 2 in the complete absence of a conventional polyadenylation signal

Nutlin‐3 treatment spares cisplatin‐induced inhibition of bone healing while maintaining osteosarcoma toxicity

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