Low-Dose Rosuvastatin Improves Arterial Stiffness in High-Risk Japanese Patients With Dyslipdemia in a Primary Prevention Group - A Comparison With Fluvastatin -

Abstract

Background:The treatment effects of rosuvastatin on arterial stiffness were assessed and compared to those of fluvastatin in high-risk Japanese patients with dyslipidemia in a primary prevention group. Methods and Results:Patients were randomly assigned to either 2.5-5 mg/day of rosuvastatin (Group A) or 20-40 mg/day of fluvastatin (Group B) and followed up for 12 months. In Group A (n=38), there was a progressive reduction in brachial-ankle pulse wave velocity (baPWV) along with a decrease in the low-density lipoprotein cholesterol/ high-density lipoprotein cholesterol (L/H) ratio and high-sensitivity C-reactive protein (hsCRP), and the change in baPWV correlated significantly with that of the L/H ratio and that of hsCRP after rosuvastatin treatment. In Group B (n=37), although fluvastatin achieved a significant improvement in baPWV, L/H ratio, and hsCRP, baPWV was significantly greater than that in Group A and showed a significant correlation with that of hsCRP alone after fluvastatin treatment. In a subgroup of patients (n=26), switching from fluvastatin to rosuvastatin further improved baPWV and the L/H ratio without altering hsCRP after 12 months. Conclusions:Low-dose rosuvastatin would be more effective than fluvastatin in improving arterial stiffness in highrisk Japanese patients with dyslipidemia. The results suggest that improvement in arterial stiffness by rosuvastatin mainly depends on its strong lipid-lowering effects, whereas that by fluvastatin is strongly dependent on the pleiotropic effects, especially an anti-inflammatory action. (Circ J 2011; 75: 2660 - 2667

Combined dyslipidemia in childhood

“…In adults with CDO, statin therapy has been shown to beneficially alter the standard lipid and LDL particle profiles and to improve multiple measures of vascular function and clinical cardiovascular outcomes. [155][156][157][158][159][160][161][162][163][164][165] In children, statin treatment has been shown to effectively lower LDL-C levels and in a small number of studies, to improve LDL-C subpopulation characteristics on NMR analysis. 166,167 Statins are also known to be antiinflammatory, which may be important in the proinflammatory state associated with obesity.…”

Management of Moderate Hypertriglyceridemia in Childhood and Adolescence

“…In adults with high TGs and CD, statin therapy beneficially alters the standard lipid and LDL particle profiles and improves vascular function and clinical cardiovascular outcomes [129][130][131]. There are as yet no published studies examining statin effects on vascular measures in youth with high TGs or CD.…”

Arterial Ageing

“…A well-known pleiotropic effect of HMG-CoA reductase inhibitors is the inhibition of the synthesis of farnesyl pyrophosphate or geranyl-geranyl pyrophosphate which is an important substrate for progerin formation 56). Some studies reported that statins suppress the progression of arterial stiffening in humans 56)57). More recently, rapamycin, which is an inhibitor of the mammalian target of rapamycin, reportedly may enhance the clearance of mutated lamin by the autophage mechanism (Fig.…”